Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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In silico prediction of anti-malarial hit molecules based on machine learning methods.

Machine learning techniques have been widely used in drug discovery and development in the areas of cheminformatics. Aspartyl aminopeptidase (M18AAP) of Plasmodium falciparum is crucial for survival of malaria parasite. We have created predictive models using weka and evaluated their performance based on various statistical parameters. Random Forest based model was found to be the most specificity...

Apr 13 2015 25869318

Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification.

BACKGROUND: It is unclear whether intensification of standard highly active antiretroviral therapy (HAART) with entry and integrase inhibitors during acute HIV infection (AHI) could yield greater benefits in reducing markers for HIV reservoir size and immune activation.

Apr 1 2015 26835516
Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity.

There is a growing need to identify new, broad-spectrum antibiotics. The natural product spergualin was previously shown to have promising anti-bacter...

Mar 30 2015 27087913
ACOustic: A Nature-Inspired Exploration Indicator for Ant Colony Optimization.

A statistical machine learning indicator, ACOustic, is proposed to evaluate the exploration behavior in the iterations of ant colony optimization algo...

Mar 30 2015 25954768
MorphoCol: An ontology-based knowledgebase for the characterisation of clinically significant bacterial colony morphologies.

BACKGROUND: One of the major concerns of the biomedical community is the increasing prevalence of antimicrobial resistant microorganisms. Recent findi...

Mar 25 2015 25817920
Assessing the effects of data selection and representation on the development of reliable E. coli sigma 70 promoter region predictors.

As the number of sequenced bacterial genomes increases, the need for rapid and reliable tools for the annotation of functional elements (e.g., transcr...

Mar 24 2015 25803493
Analysis of strand-specific RNA-seq data using machine learning reveals the structures of transcription units in Clostridium thermocellum.

Identification of transcription units (TUs) encoded in a bacterial genome is essential to elucidation of transcriptional regulation of the organism. T...

Mar 12 2015 25765651
mycoCLAP, the database for characterized lignocellulose-active proteins of fungal origin: resource and text mining curation support.

Enzymes active on components of lignocellulosic biomass are used for industrial applications ranging from food processing to biofuels production. Thes...

Mar 8 2015 25754864
The use of herbs against neglected diseases: Evaluation of leishmanicidal and trypanocidal activity of Mart.

The evaluation of the leishmanicidal and trypanocidal activity of the hydroalcoholic extract of the bark of Mart. (EHCSR) was carried out to find an ...

Mar 7 2015 28855804
Systematic artifacts in support vector regression-based compound potency prediction revealed by statistical and activity landscape analysis.

Support vector machines are a popular machine learning method for many classification tasks in biology and chemistry. In addition, the support vector ...

Mar 5 2015 25742011
Application of a hybrid method combining grey model and back propagation artificial neural networks to forecast hepatitis B in china.

Accurate incidence forecasting of infectious disease provides potentially valuable insights in its own right. It is critical for early prevention and ...

Feb 26 2015 25815044
BiNChE: a web tool and library for chemical enrichment analysis based on the ChEBI ontology.

BACKGROUND: Ontology-based enrichment analysis aids in the interpretation and understanding of large-scale biological data. Ontologies are hierarchies...

Feb 21 2015 25879798
Choose wisely: Network, ontology and annotation resources for the analysis of Staphylococcus aureus omics data.

Staphylococcus aureus (S. aureus) is a prominent human and livestock pathogen investigated widely using omic technologies. Critically, due to availabi...

Feb 14 2015 25739783
Modulation of the antibiotic activity against multidrug resistant strains of 4-(phenylsulfonyl) morpholine.

The compound 4-(Phenylsulfonyl) morpholine belongs to the class of sulfonamides, which are widely used in the treatment of a large number of diseases ...

Feb 10 2015 26858536
Describing the breakbone fever: IDODEN, an ontology for dengue fever.

BACKGROUND: Ontologies represent powerful tools in information technology because they enhance interoperability and facilitate, among other things, th...

Feb 3 2015 25646954
EcoliNet: a database of cofunctional gene network for Escherichia coli.

During the past several decades, Escherichia coli has been a treasure chest for molecular biology. The molecular mechanisms of many fundamental cellul...

Feb 2 2015 25650278
Use of uniform designs in combination with neural networks for viral infection process development.

This work aimed to compare the predictive capacity of empirical models, based on the uniform design utilization combined to artificial neural networks...

Jan 27 2015 25627917
Robotic voltammetry with carbon nanotube-based sensors: a superb blend for convenient high-quality antimicrobial trace analysis.

A new automated pharmacoanalytical technique for convenient quantification of redox-active antibiotics has been established by combining the benefits ...

Jan 27 2015 25670899
ViralmiR: a support-vector-machine-based method for predicting viral microRNA precursors.

BACKGROUND: microRNAs (miRNAs) play a vital role in development, oncogenesis, and apoptosis by binding to mRNAs to regulate the posttranscriptional le...

Jan 21 2015 25708359
Exploration of the anticandidal mechanism of Cassia spectabilis in debilitating candidiasis.

Candida albicans has become resistant to the commercially available, toxic, and expensive anti-Candida agents that are on the market. These factors fo...

Jan 19 2015 26870686
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