Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Accurate ab initio gene prediction in eukaryotes with Tiberius in multiple clades

Eukaryotic genome annotation is currently bottlenecked by limitations in the generality, scalability and accuracy of computational methods. Deep learning approaches have recently achieved large improvements in ab initio gene prediction accuracy. We extend the deep learning-based ab initio gene predictor Tiberius beyond mammals by training lineage-specific models for Mesangiospermae, Fungi, Vertebr...

Generative diffusion models for spatiotemporal influenza forecasting

Forecasting infectious disease incidence can provide important information to guide public health planning, yet is difficult because epidemic dynamics are complex. Current mechanistic and statistical approaches often struggle to capture multimodal uncertainty or emergent trends. Influpaint adapts denoising diffusion probabilistic models to epidemic forecasting. By encoding influenza seasons as spa...

Apr 27 2026 2604.24913v1
Pediatric HIV Hotspots in Kenya: Machine Learning and Geostatistical Analysis for Enhanced Case Finding

Background Although Kenya's HIV programme has long prioritized high-burden counties for intensified paediatric interventions, a critical evidence gap ...

Generative Augmentation Reveals Previously Overlooked Signals in Transcriptomic Datasets

Identifying robust gene expression signatures from transcriptomic studies with small sample sizes remains one of the most persistent challenges in com...

From Protocol to Practice: Graded Sepsis Bundle Compliance and Actionable Insights from Real-World ICU Data

Sepsis is a leading cause of in-hospital mortality, yet systematically evaluating temporal adherence to the Surviving Sepsis Campaign (SSC) bundle acr...

Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on an ancient disease with persistent, unresolved problems (DS-IAFRICA TB) study protocol

Tuberculosis (TB) is prevalent in Uganda and overlaps with a high rate of HIV/TB coinfection. While nearly all hospital-based TB cases in Kampala, the...

CellPulse: A Foundation Model of Coordinated Gene Dynamics Simulating Viral Infectious Diseases

Understanding how cells respond to perturbations like viral infections requires models capturing coordinated gene dynamics. However, current gene expr...

Identify Patients at Risk of HIV Using a Clinical Large Language Model from Electronic Health Records

This study developed a large language model (LLM)-based solution to identify people at HIV risk using electronic health records. We transformed struct...

Aiki-XP: leakage-controlled multimodal prediction of within-species relative protein expression at pan-bacterial scale

Generalizable protein-expression prediction can accelerate protein engineering, inform disease mechanisms, and help optimize heterologous recombinant ...

Learning Dynamic Representations and Policies from Multimodal Clinical Time-Series with Informative Missingness

Multimodal clinical records contain structured measurements and clinical notes recorded over time, offering rich temporal information about the evolut...

Apr 23 2026 2604.21235v1
Clinically Interpretable Sepsis Early Warning via LLM-Guided Simulation of Temporal Physiological Dynamics

Timely and interpretable early warning of sepsis remains a major clinical challenge due to the complex temporal dynamics of physiological deterioratio...

Apr 22 2026 2604.20924v1
Infection-Reasoner: A Compact Vision-Language Model for Wound Infection Classification with Evidence-Grounded Clinical Reasoning

Assessing chronic wound infection from photographs is challenging because visual appearance varies across wound etiologies, anatomical locations, and ...

Apr 21 2026 2604.19937v1
Learning to count small and clustered objects with application to bacterial colonies

Automated bacterial colony counting from images is an important technique to obtain data required for the development of vaccines and antibiotics. How...

Apr 21 2026 2604.20030v1
Machine Learning applied to MALDI-TOF data in a clinical setting: a systematic review

Bacterial identification, antimicrobial resistance prediction, and strain typification are critical tasks in clinical microbiology, essential for guid...

Inflammatory Biomarkers & Interpretable ML for SAP Risk Stratification in AIS Patients Undergoing Bridging Therapy

Stroke-associated pneumonia (SAP) is a common, severe complication in acute ischemic stroke (AIS) patients receiving bridging therapy (intravenous thr...

CSRA: Controlled Spectral Residual Augmentation for Robust Sepsis Prediction

Accurate prediction of future risk and disease progression in sepsis is clinically important for early warning and timely intervention in intensive ca...

Apr 16 2026 2604.14532v1
Quality-Aware Calibration for AI-Generated Image Detection in the Wild

Significant progress has been made in detecting synthetic images, however most existing approaches operate on a single image instance and overlook a k...

Apr 16 2026 2604.15027v1
U-Probe: universal agentic probe design for imaging-based spatial-omics

Probe design for fluorescence in situ hybridization (FISH) underpins spatial transcriptomics, three-dimensional genome studies, and clinical diagnosti...

Community needs for FAIR pathogen data

Background: Datasets related to infectious diseases are essential for public health decision-making, yet their reuse remains limited by persistent bar...

Explainable Fall Detection for Elderly Care via Temporally Stable SHAP in Skeleton-Based Human Activity Recognition

Fall detection in elderly care requires not only accurate classification but also reliable explanations that clinicians can trust. However, existing p...

Apr 14 2026 2604.13279v1
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