Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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A Statistical Approach for Modeling Irregular Multivariate Time Series with Missing Observations

Irregular multivariate time series with missing values present significant challenges for predictive modeling in domains such as healthcare. While deep learning approaches often focus on temporal interpolation or complex architectures to handle irregularities, we propose a simpler yet effective alternative: extracting time-agnostic summary statistics to eliminate the temporal axis. Our method comp...

Feb 23 2026 2602.19531v1

Bacterial protein function prediction via multimodal deep learning

Bacterial proteins are specialized with extensive functional diversity for survival in diverse and stressful environments. A significant portion of these proteins remains functionally uncharacterized, limiting our understanding of bacterial survival mechanisms. Hence, we developed Deep Expression STructure (DeepEST), a multimodal deep learning framework designed to accurately predict protein funct...

Genomic-island cassette architecture drives pathogenic Enterococcus cecorum lineages: Cassette2Vec-EC, a structural genomics and machine-learning framework

Mobile genetic elements and genomic islands (GIs) frequently encode antibiotic resistance and host-adaptation cargo, yet routine genome comparison pip...

Integrated Molecular and AI-Based Diagnostics for Banana Diseases: Development, Optimization, and Field Deployment of LAMP and Computer Vision Technologies

Banana and plantain (Musa spp.) production in Sub-Saharan Africa is severely constrained by multiple diseases, with Banana bunchy top virus (BBTV) rep...

SubQuad: Near-Quadratic-Free Structure Inference with Distribution-Balanced Objectives in Adaptive Receptor framework

Comparative analysis of adaptive immune repertoires at population scale is hampered by two practical bottlenecks: the near-quadratic cost of pairwise ...

Feb 19 2026 2602.17330v1
Machine learning-based framework for predicting human infection potential of coronavirus associated with tri-amino acid motifs, KIQ and LEP in spike protein

Assessing the human infection potential of emerging coronaviruses remains a critical challenge for global health preparedness. In this study, we devel...

Programmable RNA detection generates DNA barcodes for multiplexed phage-host interaction screening

Here, we introduce Detectrons, modular biosensors that couples programmable toehold switches with retron-mediated reverse transcription to transduce R...

Spatially Resolved Reaction-Diffusion Modeling Reveals Effects of Intracellular Spatial Heterogeneity on Yeast Galactose Network Dynamics

Eukaryotic cells are spatially organized into functionally-distinct compartments. This three-dimensional(3D) organization generates intracellular hete...

Formally Verifying and Explaining Sepsis Treatment Policies with COOL-MC

Safe and interpretable sequential decision-making is critical in healthcare, yet reinforcement learning (RL) policies for sepsis treatment optimizatio...

Feb 16 2026 2602.14505v1
Universal Image Immunization against Diffusion-based Image Editing via Semantic Injection

Recent advances in diffusion models have enabled powerful image editing capabilities guided by natural language prompts, unlocking new creative possib...

Feb 16 2026 2602.14679v1
Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies

Recent advances in machine learning (ML)-based protein design methods have enabled the rapid in silico generation of large libraries of miniprotein bi...

Feature-based in-silico model to predict the Mycobacterium tuberculosis bedaquiline phenotype associated with Rv0678 variants

Bedaquiline resistance is emerging globally and threatens the effectiveness of the novel short all-oral regimens for rifampicin-resistant tuberculosis...

Inferring unobserved vector dynamics for dengue forecasting using physics-informed neural networks and mechanistic transmission models

Accurately characterising mosquito infection dynamics is essential for effective dengue prevention and control, yet these dynamics are rarely observab...

ChatDIA: A zero-shot large language model workflow for targeted analysis of data-independent acquisition mass spectrometry data

Data-independent acquisition (DIA) proteomics enables reproducible, large-scale protein identification and quantification but remains challenging to a...

Robust machine learning for Clostridioides difficile typing from mass spectrometry via data augmentation

Machine learning (ML) approaches applied to Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) spectra have s...

Calibrated Bayesian Deep Learning for Explainable Decision Support Systems Based on Medical Imaging

In critical decision support systems based on medical imaging, the reliability of AI-assisted decision-making is as relevant as predictive accuracy. A...

Feb 12 2026 2602.11973v1
Wastewater-informed neural compartmental model for long-horizon case number projections

Wastewater-based epidemiology provides a low-cost, scalable view of community infection dynamics, but converting these signals into actionable epidemi...

Metagenomic strain tracking reveals patterns of bacterial spread and the impact of water chlorination

Bacterial infections are a major cause of morbidity and mortality among children under five in low- and middle-income countries (LMICs). Children in L...

BRIDGE: Biological Antimicrobial Resistance Inference viaDomain-Knowledge Graph Embeddings

Antimicrobial resistance (AMR) is a growing global health crisis, responsible for an estimated 1.27 million deaths in 2019 alone. traditional approach...

LLM-based reconstruction of longitudinal clinical trajectories in chronic liver disease.

Background: Liver cancer primarily develops in patients with chronic liver disease (CLD), yet most cases are diagnosed at an advanced stage with poor ...

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