Latest AI and machine learning research in infectious disease for healthcare professionals.
Type IV secretion systems (T4SS) enable the spread of antibiotic resistance and other virulence factors. In Gram-positive bacteria, T4SSs have long been thought to lack VirB2-like proteins that form conjugative pili and instead rely on adhesins for cell-cell contacts. Yet, it has remained unclear how subsequent DNA transfer (conjugation) is physically mediated. Here we identify a VirB2-like protei...
Malaria in sub-Saharan Africa is transmitted by mosquitoes, in particular the Anopheles gambiae complex. Efforts to control the spread of malaria have often focused on these vectors, but less is known about the demographic history of populations and species in the Anopheles complex. Here, we first quantify the genetic structure of mosquito populations in sub-Saharan Africa using unsupervised machi...
Effectors are pathogen proteins that facilitate infection by manipulating plant immunity. Computational programs have been developed that identify eff...
Genomic language models (gLMs) have recently emerged as powerful numerical surrogates for DNA, but existing architectures are largely focused on human...
The expression of antibiotic-inactivating enzymes, such as Pseudomonas-derived cephalosporinase-3 (PDC-3), is a major mechanism of intrinsic resistanc...
Zoonotic viruses capable of jumping from animal reservoirs into human populations represent a persistent and unpredictable menace to global health. To...
Over 100 genes have been implicated in congenital heart disease (CHD), yet the genetic basis for >50% of CHD remains unexplained. A key challenge is t...
Antimicrobial resistance is a growing global health concern, requiring reliable tools for predicting resistance across a wide range of bacteria and an...
As biology becomes increasingly data-driven, so too does the field of phage lysins, enzymes that degrade bacterial cell walls and hold promise as alte...
The selection of an effective adjuvant is a critical bottleneck in vaccine development, particularly for emerging diseases where experimental data is ...
Biological neural networks contain diverse cell types with heterogeneous electrophysiological properties. Artificial neural networks (ANNs) model comp...
In addition to storing molecular oxygen, myoglobin catalyzes peroxidase-like reactions involving high valency iron(IV)-oxo species that support oxidat...
Clinical microbiology laboratories play a crucial role in identifying pathogens, guiding antibiotic treatment, and managing antimicrobial resistance (...
Antibodies serve as vital diagnostic and therapeutic agents due to their exceptional specificity toward antigenic targets. Mapping antibody–antigen in...
Pneumonia, primarily caused by Streptococcus pneumoniae, and tuberculosis (TB), caused by Mycobacterium tuberculosis, continue to present significant ...
Several clinical prediction models have been developed using electronic health records data to help inform decisions about HIV pre-exposure prophylaxi...
Traditional diagnostic methods for Tuberculous pleural effusion (TPE) are often limited by their invasiveness, low sensitivity, and lack of accessibil...
Acute diarrheal disease is one of the leading causes of death in children under age 5, disproportionately impacting children in low-resource settings....
Mosquito-borne diseases cause millions of deaths each year and are increasingly spreading from tropical and subtropical regions into temperate zones, ...
Major Adverse Kidney Events within 30 days (MAKE30) is an important patient-centered outcome for assessing the impact of acute kidney injury (AKI). Th...