Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Cough Audio Recognition for Early Detection of Respiratory Diseases: Algorithm Development and Validation Study.

BACKGROUND: Coughing is a common clinical symptom and a protective respiratory reflex closely associated with various respiratory system diseases. The acoustic characteristics of cough sounds are influenced by underlying pathological factors, with distinct acoustic signatures corresponding to different etiologies. Through rigorous analysis of these sounds, rapid identification and preliminary diag...

May 7 2026 42096594

A comparison of two- and three-dose MVA-BN mpox vaccination series on anti-monkeypox virus immunity.

The 2022 global outbreak of clade IIb mpox represented a turning point in public health's handling of poxviruses. The primary vaccine available for the prevention of mpox is modified vaccinia Ankara from Bavarian-Nordic (MVA-BN). We previously reported a nondurable and low-avidity antibody response against mpox elicited by MVA-BN. In this study, we expanded upon this knowledge by employing a micro...

May 7 2026 42098158
Prediction of SARS-CoV-2 exposure through T cell activation profiles.

In the ongoing effort to study the SARS-CoV-2 virus and COVID-19 disease, assessment of the T cell immune response has guided vaccine and therapeutic ...

May 7 2026 42098250
Comprehensive cross-cohort analysis reveals global gut microbiome signatures of celiac disease.

BACKGROUND: Celiac disease affects ~1-2% of people and remains incurable, requiring lifelong dietary restriction. The gut microbiome is thought to con...

May 7 2026 42098439
Leveraging large language models on free-text symptoms from participatory surveillance enhances pertussis forecasting in the United States.

BACKGROUND: Declines in childhood vaccination in the U.S. have contributed to a resurgence of vaccine-preventable diseases, including a notable increa...

May 7 2026 42098644
Health AI research capacity and equity-adjusted patient value in 27 European Union countries: an ecological panel study, 2011-2024.

BACKGROUND: Investments in health artificial intelligence (AI) are accelerating across European Union member states, yet evidence linking national AI ...

May 7 2026 42098703
Mechanistically Informed and Omics-Guided Essential Oil Applications for Food Preservation.

The growing demand for safe, sustainable, and clean-label food preservation strategies has accelerated interest in plant-derived essential oils (EOs) ...

May 6 2026 42103286
Machine learning-driven clinical decision support for liver cirrhosis: a gut microbiome-based web prediction model with explainable AI integration.

BACKGROUND: Liver cirrhosis (LC) is a chronic liver disease with global prevalence. Current diagnostic methods for LC still face limitations in safety...

May 6 2026 42092798
Machine Learning-Driven Simulations of the SARS-CoV-2 Fitness Landscape from Deep Mutational Scanning Experiments.

Predicting protein variant effects is a key challenge in preparing for pathogenic viral strains, understanding mutation-linked diseases, and designing...

May 6 2026 42089465
A Lightweight LSTM-Transformer Fusion Architecture for Real-Time Sepsis Mortality Prediction.

BackgroundAccurate prediction of short-term mortality in sepsis patients is critical for timely clinical decision-making. However, existing deep learn...

May 6 2026 42089722
Deep Learning Algorithms Versus Radiologists in Digital Breast Tomosynthesis for Breast Cancer Detection: Systematic Review and Meta-Analysis.

BACKGROUND: Deep learning (DL) algorithms for digital breast tomosynthesis (DBT) have proliferated, demonstrating emerging potential in enhancing lesi...

May 6 2026 42090319
Harnessing Terminal Signal-Aware Deep Learning for Accurate Multi-Class Secreted Effector Identification.

Gram-negative bacterial secreted effectors are translocated through specialized secretion systems to manipulate host cellular processes, and their acc...

May 6 2026 42090538
Evaluating the Potential Impact of AI on Urinary Tract Infection Diagnosis in the Emergency Department Across Demographic Groups: Retrospective Cohort Study.

BACKGROUND: Urinary tract infection (UTI) is a common emergency department (ED) presentation but can be challenging to diagnose; both overdiagnosis an...

May 6 2026 42090580
Diagnostic Proficiency of Large Language Models in the Interpretation of Cervical Cytopathology.

To evaluate the diagnostic proficiency of well-established multimodal Large Language Models (LLMs)-specifically Gemini, Claude, and Copilot-in interpr...

May 6 2026 42091049
Early sepsis prediction using a hybrid LSTM-GAT model: a study on the PhysioNet 2019 dataset.

OBJECTIVE: Sepsis is a potentially fatal systemic response to infection, in which early clinical intervention is critical to reduce mortality. This st...

May 6 2026 42091169
Hierarchical knowledge distillation framework for efficient node influence prediction in large-scale complex networks.

Node influence prediction is fundamental to epidemic control, viral marketing, and infrastructure resilience, yet traditional susceptible-infected-rec...

May 6 2026 42091968
Beyond NIHSS and neuroimaging: an interpretable gradient boosting model for predicting in-hospital mortality in ICU patients with acute ischemic stroke.

This study aimed to develop an interpretable machine learning model for predicting in-hospital mortality among acute ischemic stroke (AIS) patients ad...

May 6 2026 42092094
Time-synthetic optical neural networks with stable programmable gain.

Optical neural networks (ONNs) offer ultrafast and energy-efficient artificial intelligence, yet their effective depth remains fundamentally limited b...

May 6 2026 42086569
Research progress on biomarkers for acute kidney injury in children.

Pediatric acute kidney injury (AKI) often presents insidiously and progresses rapidly. Traditional diagnostic criteria based on serum creatinine and u...

May 6 2026 42086806
Design and in silico evaluation of an mRNA vaccine against HTLV-1 using AI-driven reverse vaccinology approaches.

Human T-lymphotropic virus type 1 (HTLV-1) is the first discovered human oncogenic retrovirus that can cause adult T-cell leukemia/lymphoma, HTLV-1-as...

May 6 2026 42090365
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