Infectious Disease

Discovery of bacterial biofilm inhibitors against catheter-associated urinary tract infections using computational approaches.

One of the most frequent device-associated infections obtained in a hospital setting is catheter-ass...

Complete Blood Count Interpretation in Dogs and Cats and Its Analytical Compatibility with Vis-NIR Point-of-Care Hematology: A Systematic Literature Review with Narrative Synthesis.

This systematic literature review with narrative synthesis assessed the diagnostic contribution of c...

When "Non-VCTE" Does Not Mean VCTE-Free: Reassessing Machine Learning-Based HCC Prediction in Chronic Hepatitis B.

Discovery of dietary polyphenols targeting the autoinducer-2 quorum sensing system of pathogenic bacteria.

Targeting autoinducer-2 (AI-2) quorum sensing (QS) systems with dietary compounds represents a promi...

Machine Learning and Statistical Models for Genomic Selection of Phytophthora Fruit Rot Resistance in Watermelon.

Breeding for Phytophthora fruit rot (PFR) resistance caused by the devastating pathogen Phytophthora...

Discovery and Biological Characterization of 1-[4-(2-Difluoromethoxyphenyl)-5-methylthiazol-2-yl]-3-(naphthalen-1-yl)urea (DFMNTU): A Novel Thiazolyl-Urea Chemotype Targeting Yellow Fever Virus and Host Casein Kinase 2 (CK2).

Yellow fever virus (YFV) is a re- emerging mosquito- borne flavivirus that causes severe hemorrhagic...

Biomedical Applications of Antimicrobial Peptides: Multifunctional Mechanisms, Engineering Strategies, and Therapeutic Development.

Antimicrobial peptides (AMPs) are small, multifunctional molecules generated by the innate immune sy...

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches.

Antiretroviral pre-exposure prophylaxis (PrEP) is less effective in women than expected, partly beca...

Spike antibody Fc is associated with protection from SARS-CoV-2 challenge in macaques.

A definitive correlate of protection (CoP) for SARS-CoV-2 has yet to be formally established. We pre...

Emerging Industrial Pollutants in Wastewater: Occurrence, Environmental Fate, Toxicological Mechanisms and Treatment Strategies.

With the accelerated industrialization, the emission of emerging pollutants has increased in aquatic...

Dynamic, model-guided intensification of fuel ethanol production in yeast: proteome constraints, CRISPR rewiring, and high-gravity fermentations.

The production of fuel ethanol by Saccharomyces cerevisiae is the consequence of the coupling betwee...

Genomic signatures associated with antibiotic resistance and predictive modelling in Pseudomonas aeruginosa.

Pseudomonas aeruginosa is a major opportunistic pathogen with a remarkable capacity to develop resis...

Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes.

INTRODUCTION: Natural hosts of simian immunodeficiency virus (SIV), including sooty mangabeys (SMs),...

ALPS-HCC Score: A Dynamic Liver Stiffness Measurement-Based Machine Learning Model to Predict Risk of Hepatocellular Carcinoma.

BACKGROUND & AIMS: Existing hepatocellular carcinoma (HCC) risk scores specific to chronic hepatitis...

Development of a Machine Learning Model to Predict Short Duration HCV Treatment Response.

Standard durations of direct acting antivirals (DAAs; 8-12 weeks) can be a barrier to HCV treatment ...

Are hyaluronic acid synthases widely encoded in fungi?

Hyaluronic acid (HA) is a biologically versatile polysaccharide synthesized by vertebrates and sever...

A Machine Learning-Derived Risk Scorecard for Pneumonia Hospitalization in Japanese Old-Old Adults.

AIM: To develop and internally validate a machine learning-based risk scorecard for 1-year pneumonia...

White Blood Cell to HDL-C Ratio and Sarcopenia: A Dual-Cohort Analysis Including Exploratory Insights on Hepatitis B History.

BACKGROUND: Sarcopenia, driven by inflammation and lipid dysregulation, lacks inexpensive screening ...

From Rhizosphere to Resistance: Microbe-Plant Interactions in Eco-Smart Biocontrol.

The increasing limitations of chemical pesticides such as environmental pollution, pathogen resistan...

Identification and functional characterization of ASCC2 as a diagnostic biomarker and immune regulatory hub in Kawasaki disease.

BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis in children, yet its molecular mec...

MADE: leveraging informative missingness and temporal evaluation for electronic health record-based deterioration prediction in general wards.

OBJECTIVE: Electronic health record (EHR) time series are irregularly sampled and frequently incompl...