Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Comparative urinary metabolomics reveals unique and shared pathways in COVID-19 and liver diseases.

INTRODUCTION: The COVID-19 pandemic and liver diseases both cause significant metabolic disturbances, yet the specific mechanisms driving these changes remain poorly understood. OBJECTIVES: This study aimed to elucidate and compare the urinary metabolomic profiles of COVID-19 patients, individuals with liver diseases, and healthy controls to determine common and unique metabolic signatures between...

Feb 27 2026 41758429

MDDTA: A Drug Target Binding Affinity Prediction Method Based on Molecular Dynamics Simulation Data Enhancement.

Deep learning-based methods for drug target binding affinity (DTA) prediction are improving the efficien cy of drug screening, but some limitations persist in current methodologies. Notably, prevailing models predominantly rely on static structural data while neglecting the conformational dynamics of drug target complexes, which compromises their capacity to discern subtle conformation dependent a...

Feb 27 2026 41758859
AI-enhanced therapeutic drug monitoring for vancomycin and β-lactam antibiotics in critical care: from population PK to bedside algorithms.

INTRODUCTION: Although sepsis and other severe infections in intensive care are common and deadly, obtaining safe and effective exposure for vancomyci...

Feb 27 2026 41760398
Fcer1g and St3gal1: Macrophage-associated angiogenesis biomarkers and therapeutic targets in sepsis-induced acute lung injury.

BACKGROUND: Acute lung injury (ALI) involves the release of growth factors and inflammatory mediators from damaged pulmonary tissues, fostering endoth...

Feb 27 2026 41758834
Distinguishing post-COVID from long-COVID in adults: Development and validation of a biomarker signature using targeted proteomics and machine learning in a cross-sectional observational study.

BACKGROUND: COVID-19 can have diverse clinical manifestations, ranging from asymptomatic infection to critical illness with multiorgan involvement. Wh...

Feb 27 2026 41758880
Integrated machine learning risk model for predicting radiation pneumonitis in lung cancer patients with interstitial lung disease.

BACKGROUND: Radiation pneumonitis (RP) is a serious complication in lung cancer patients with pre-existing interstitial lung disease (ILD) undergoing ...

Feb 26 2026 41755502
Acute respiratory infection (COVID-19) risk prediction in travelers: A random forest model.

BACKGROUND: Early screening during outbreaks of acute respiratory infections (ARIs) is critical for controlling disease spread among international tra...

Feb 26 2026 41810134
Data-driven model analysis of the impact of environmental and socioeconomic factors on tuberculosis incidence.

Tuberculosis (TB), a global infectious disease, poses a formidable challenge to Taiwan, China, exacerbated by its aging demographic and the incursion ...

Feb 26 2026 41810135
New treatments to rabies virus infections.

Rabies disease is the deadliest of all virus infections. Till now, vaccination is the most effective and reliable treatment for controlling rabies. Ho...

Feb 26 2026 41759787
Identifying Subgroups of People Living With HIV in British Columbia, Canada Based on Sexually Transmitted and Blood-Borne Infection Testing and Diagnostic Laboratory Data: A Retrospective Cohort Study.

BACKGROUND AND AIMS: Although combination antiretroviral therapy has decreased morbidity and mortality in people living with HIV (PLWH), the prevalenc...

Feb 26 2026 41767358
Identification of key genes modules linking brain aging signatures and COVID-19-associated cognitive impairment.

BACKGROUND: Emerging evidence indicates that SARS-CoV-2 infection is associated with aging, particularly in memory-related domains. However, the molec...

Feb 26 2026 41763362
Synergizing Artificial Intelligence with In Vivo CAR-T Cell Generation: A New Paradigm for Democratized Immunotherapy.

In vivo CAR-T cell generation represents a paradigm shift in immunotherapy by transitioning the production of chimeric antigen receptor (CAR) T cells ...

Feb 26 2026 41763635
Visualization of Breast Reconstruction Outcomes Using an Artificial Intelligence-Enabled Simulator.

INTRODUCTION: Visual aids that simulate personalized postoperative outcomes following breast reconstruction may facilitate shared decision-making and ...

Feb 26 2026 41758118
Early hemodynamic phenotyping in sepsis using transthoracic echocardiography: A proof-of-concept study in a north African ICU.

BACKGROUND: Cardiovascular dysfunction in sepsis is heterogeneous and contributes to poor outcomes. Hemodynamic phenotyping may delineate pathophysiol...

Feb 26 2026 41759300
Machine learning analysis of s-EASIX for predicting 30-day mortality in sepsis patients from MIMIC-IV.

Endothelial dysfunction is an important risk factor for the progression of sepsis. The simplified endothelial activation and stress index (s-EASIX) se...

Feb 26 2026 41741568
Peroxidase-Mimicking Nanozymes for Rapid Detection of Infectious Diseases.

Infectious diseases pose a critical global health threat, and rapid and sensitive diagnostics are essential for effective intervention. Conventional m...

Feb 26 2026 41742896
Multicounty Outbreak of Salmonella Agbeni Linked to Ice in a Cooler at a County Fair - Illinois, August 2024.

On August 5, 2024, the Brown County (Illinois) Health Department (BCHD) was informed by the county sheriff that numerous potential jurors being screen...

Feb 26 2026 41747166
A dataset of midpalatal suture maturation stage in cone-beam computed tomography.

In the field of orthodontics, the degree of fusion of the midpalatal suture (MPS) is a crucial factor in determining the most appropriate maxillary ex...

Feb 26 2026 41748575
A novel hybrid model for species distribution prediction of soil-transmitted helminthiasis (STH) under soil temperature conditions using Random Forest and Particle Swarm Optimization Algorithm.

Soil Transmitted Helminthiases (STH) are among the most common neglected tropical diseases in Nigeria, primarily transmitted through soil contaminated...

Feb 26 2026 41748615
A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

Computational blind challenges offer critical, unbiased opportunities to assess and accelerate scientific progress, as demonstrated by a breadth of br...

Feb 26 2026 41749419
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