Kidney Transplantation

Alignment Between Cardiologists and AI-Driven Diagnostic Systems: Mixed Methods Study.

BACKGROUND: The clinical value of artificial intelligence (AI)-based diagnostic systems depends not only on their accuracy but also on how well their outputs integrate with clinicians' judgments in practice. Critical knowledge gaps remain regarding diagnostic concordance between AI and clinicians in stress echocardiography interpretation, patient characteristics predicting discordance, and how car...

Prospects and Challenges of Personalized Immunotherapy in Breast Cancer Treatment and Long-term Cancer Management.

Breast cancer is highly heterogeneous,and different molecular subtypes exhibit significant variations in their response to immunotherapy.While significant progress has been achieved in the development of immune checkpoint inhibitors,chimeric antigen receptor T-cell therapies,and personalized cancer vaccines for breast cancer,the immunosuppressive nature of the breast cancer tumor microenvironment,...

Multimodal Artificial Intelligence for Early Detection and Precision Management of Inflammatory and Infiltrative Cardiomyopathies.

BACKGROUND: Inflammatory and infiltrative cardiomyopathies, including cardiac sarcoidosis, transthyretin amyloidosis, and autoimmune myocarditis, are ...

Synthetic Inducible Bacteria Normalize the Microenvironment of Refractory Tumors, Potentiating Checkpoint Inhibitor Responses.

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...

Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism.

The discovery of selective immunosuppressants for T cell-mediated diseases like Ulcerative Colitis (UC) is a significant challenge. While traditional ...

Integrative multi-omics analysis identifies a core ferroptosis signature and validates resveratrol as a novel inducer in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to treatment resistance and an immunosuppressive, fibrotic microenvironment. Ferrop...

TIME: A Taylor-Inspired Mixed-Effects Model for IDH Prediction.

BACKGROUND: Intradialytic hypotension (IDH) is a critical complication in hemodialysis that increases morbidity and treatment risks, yet existing mach...

Integrating spatial and single-cell transcriptomics via machine learning to characterize efferocytosis in hepatocellular carcinoma prognosis and immunotherapy.

BACKGROUND: The intratumoral heterogeneity and immunosuppressive microenvironment of hepatocellular carcinoma (HCC) significantly limit therapeutic ef...

Immunological Drug-Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence.

PURPOSE OF REVIEW: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, producing durable responses across multiple malignancies. Howe...

Neuro-Adaptive Integral Sliding-Mode Consensus Control for Multi-ASVs With Unknown Nonlinearity via Dissipative Disturbance Estimation.

This article investigates a dissipative disturbance-estimator (DDE)-based neuro-adaptive integral sliding-mode control (ISMC) for multiple autonomous ...

Single-cell and machine learning reveal ROS-associated heterogeneity in hepatocellular carcinoma for precision medicine.

BACKGROUND: Reactive oxygen species (ROS) are critical regulators of tumor development and progression, yet their clinical significance and cellular m...

Hemovigilance in a Brazilian Amazon blood center: A temporal analysis of 5-year consumption patterns.

BACKGROUND: The transfusion of blood components remains a cornerstone in the management of hematological and onco-hematological diseases. Effective bl...

Single-cell and deep learning identify hypoxia-responsive lncRNAs predicting outcomes in colorectal cancer.

Emerging evidence highlights hypoxia-responsive long non-coding RNAs (lncRNAs) as potential modulators in tumor biology. In this study, we explored th...

A predictive 14-gene signature and FLI1 inhibition overcome tumor-infiltrating lymphocyte dysfunction in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Although immune checkpoint inhibitors such as pemb...

Copper transporters promote the malignant progression of glioblastoma by regulating the immunosuppressive tumour microenvironment via the SLC31A1-WNT5A axis.

BACKGROUND: The prognosis for patients with glioblastoma (GBM) remains extremely poor, a challenge largely attributable to the complex nature of its m...

Involved nodal versus elective neck radiotherapy (INVERT) for head and neck squamous cell carcinoma: a prospective phase II randomized controlled trial protocol.

BACKGROUND: Definitive chemoradiotherapy for head and neck squamous cell carcinomas (HNSCC) carries significant long-term toxicities, with elective ne...

Screening of Sepsis Diagnostic Biomarkers Based on Fumarate Metabolism-Related Genes with Analysis of Immune Infiltration and Subtype Identification.

BACKGROUND: Sepsis is a major global health challenge characterized by a complex pathogenesis involving an early hyperinflammatory phase followed by a...

Characterization of telomere-related gene subtypes in lung adenocarcinoma and their implications for prognosis and treatment.

BACKGROUND: Telomeres, located at chromosome ends, regulate cell division and maintain genomic stability. Telomere-related genes (TRGs) play essential...

Single-cell profiling identifies a pro-tumoral VCAN positive macrophage subset and defines a prognostic signature in glioblastoma.

Glioblastoma (GBM), the most aggressive primary brain tumor, develops within a tumor microenvironment (TME) dominated by tumor-associated macrophages ...

Integrating machine learning and single-cell sequencing to reveal the role of kinase-related genes in subtype classification and prognostic significance of lung squamous cell carcinoma.

BACKGROUND: Lung squamous cell carcinoma (LUSC) exhibits poor prognosis and a highly complex tumor immune microenvironment (TIME), creating an urgent ...