Transplantation

Kidney Transplantation

Latest AI and machine learning research in kidney transplantation for healthcare professionals.

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Integrated single-cell and bulk transcriptomics reveals STAB1 as a novel therapeutic target for ovarian cancer.

The immunosuppressive tumor microenvironment (TME) and intrinsic heterogeneity of ovarian cancer (OC) are primary drivers of therapeutic resistance and mortality. To deconvolute these complex dynamics and identify robust therapeutic targets, this study employed an integrative strategy combining ensemble machine learning algorithms with high-resolution single-cell transcriptomics and experimental v...

Mar 21 2026 41865597

Attitudes toward artificial intelligence among individuals with anxiety, depression, bipolar disorders, and schizophrenia.

BACKGROUND: Artificial intelligence (AI) increasingly supports medical diagnosis, interventions, and clinical decision-making. In various domains of human communication, AI systems based on large language models offer effective tools for conducting interviews, supportive dialogue, and engaging in problem-focused discussions with healthy individuals and clinical patients. In contemporary clinical s...

Mar 20 2026 41921249
Application of machine learning in the research progress of post-kidney transplant rejection.

Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs. With the rapid adv...

Mar 18 2026 41607813
Protocol for a global electronic Delphi on integrating artificial intelligence into solid organ transplantation.

Artificial intelligence (AI) is increasingly recognized as a transformative force in the field of solid organ transplantation. From enhancing donor-re...

Mar 18 2026 41607824
Immune checkpoint molecules beyond PD-1 and CTLA-4: emerging targets in autoimmune diseases and cancer immunotherapy.

BACKGROUND: Immune checkpoint molecules are pivotal regulators of immune activation and tolerance, playing critical roles in cancer, autoimmunity, inf...

Mar 17 2026 41842954
Comprehensive Multiomics Characterization of Perineural Invasion in Cervical Cancer Reveals Diagnostic Markers, Molecular Drivers, and Therapeutic Strategies.

UNLABELLED: Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is associated with poor prognosis and provides key in...

Mar 16 2026 41379570
Discovery of Novel MLKL PROTAC Degraders for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos.

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, primarily due to its low immunogenicity and immunosuppre...

Mar 16 2026 41834604
Machine Learning Prediction of Progression to Dialysis in Patients With Polycystic Kidney Disease: Population-Based Retrospective Cohort Study.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst growth and renal decline, is the leading genetic c...

Mar 16 2026 41838891
Influence of blood transfusion on outcomes in patients with gastric cancer.

Chen et al's research provides valuable data supporting the cautious use of transfusions during gastric cancer surgery. However, to interpret causalit...

Mar 14 2026 41809457
Loop of N2-polarized neutrophils and exhausted CD8 + T cells induces immunotherapy resistance in NSCLC.

While neutrophils represent a prominent myeloid component in non-small cell lung cancer (NSCLC), the specific immunosuppressive functions of N2-polari...

Mar 13 2026 41824204
Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect.

BACKGROUND: Tacrolimus is a first-line immunosuppressant essential for preventing graft rejection after liver transplantation, but its narrow therapeu...

Mar 12 2026 41821195
Artificial intelligence-assisted spatial omics-based biomimetic nanoplatform for intelligent and precise intervention in the immunosuppressive core region of ovarian cancer.

Ovarian cancer (OC) ranks among the most aggressive malignancies of the female reproductive system. The immunosuppressive tumor microenvironment (TME)...

Mar 11 2026 41814059
A metabolic-immune subtype of breast cancer defined by G6PD and SHMT2: From single‑cell dissection to dual-targeted therapy.

Breast cancer heterogeneity limits the precision of current prognostic and therapeutic strategies, underscoring the need for molecular frameworks that...

Mar 10 2026 41819344
Precision immunotherapies for systemic lupus erythematosus: From pathogenic targets to translational horizons.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder in which aberrant B-cell activation, persistent autoantibody production, and...

Mar 9 2026 41812738
AIPsychoBench: Understanding the Psychometric Differences Between LLMs and Humans.

Large Language Models (LLMs) with hundreds of billions of parameters have exhibited human-like intelligence by learning from vast amounts of internet-...

Mar 9 2026 41802162
Identification of core genes mediating the association between obesity and hepatocellular carcinoma: A bioinformatics study based on mitochondrial metabolism and immune pathways.

PURPOSE: Obesity is strongly associated with hepatocellular carcinoma (HCC), yet the molecular mechanisms linking them remain unclear. This study aime...

Mar 9 2026 41801960
Increased Prevalence of Extrathymic Neoplasms in Myasthenia Gravis Patients-A Population-Based, Matched Case-Control Study.

INTRODUCTION/AIMS: Myasthenia gravis (MG) is associated with thymic neoplasms. However, an increased prevalence of extrathymic neoplasms has also been...

Mar 7 2026 41795172
Predicting Behavioral Reliance on AI-Based Depression Treatment Recommendations Among Engineering Graduate Students: A Pilot Study Using EEG Signals.

OCCUPATIONAL APPLICATIONSThis pilot study demonstrates the feasibility of using EEG-derived features to characterize behavioral reliance among enginee...

Mar 7 2026 41793711
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