Kidney Transplantation

Preoperative Risk Score for Mortality Within 3 Years of Elective Aortobifemoral Artery Bypass.

BACKGROUND: The purpose of this study was to create a risk score for mortality within 3 years of elective aortobifemoral artery bypass for aortoiliac arterial occlusive disease based on variables at the time of preoperative clinical presentation utilizing 5,912 patients in the Vascular Quality Initiative (VQI). METHODS: Multivariable Cox regression time-dependent analysis was performed for the out...

Role of the gut microbiome in shaping drug response in immunocompromised hosts.

BACKGROUND: There is an increasing amount of evidence on microbiome-drug interactions in several clinical settings, including in immunocompromised patients. The gut microbiome has been shown to directly and indirectly influence drug efficacy and toxicity, offering high potential for clinical translation. OBJECTIVES: This narrative review aims to provide an up-to-date overview of the relationship b...

Highly sensitive superhydrophobic SERS substrate combined with machine learning for precise identification and classification of nanoplastics.

The ubiquitous use of plastics in modern society is accompanied by the pervasive occurrence of plastic pollution. Of particular concern are nanoplasti...

Disturbance modeling compensation predictive LADRC of tank gun control system using self-attention mechanism based bi-LSTM network.

In order to address the tracking accuracy degradation of the tank gun control system (TGCS) with inherent structural nonlinearity and feedback hystere...

From Antigen to Atlas: A Multi-omics, Single-Cell Pipeline for Discovering Safe and Effective CAR Targets in Ovarian Cancer.

Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable success in hematologic malignancies but continues to face significant barriers ...

Decoding the Glioblastoma Microenvironment: AI-Driven Analysis of Cellular MRI Signatures for Targeted Therapy.

Glioblastoma (GB), the most aggressive primary brain tumor, is characterized by profound inter- and intratumoral heterogeneity and a highly immunosupp...

Challenges and advances in drug resistance and tolerance in cancer.

Therapeutic resistance remains the principal barrier to durable clinical benefit in oncology, particularly in oncogene-driven malignancies and immune-...

STAND-Net: A Spiking Temporal Attention autoeNcoDer Network for Efficient EEG Artifact Removal.

Electroencephalography (EEG)-based brain computer interface (BCI) systems hold significant promise across diverse applications; however, their perform...

GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma.

Despite the increasing recognition of pyroptosis, particularly that involving GSDME, its precise impact on tumor prognosis and the immune microenviron...

Integrative multi-omics analysis reveals metabolic dysfunction signatures as critical determinants of prostate cancer prognosis and immunosuppressive microenvironments.

BACKGROUND: Metabolic reprogramming is a hallmark of cancer. However, the precise mechanisms by which specific metabolic pathways drive prostate cance...

Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma.

Hepatocellular carcinoma remains a leading cause of cancer mortality worldwide, with peritumoral microenvironment interactions playing a critical role...

Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response.

UNLABELLED: Multiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In thi...

Exploring factors and models to predict post-dialysis volume overload status in maintenance hemodialysis patients based on pre-dialysis parameters.

OBJECTIVE: This study explored factors and models to predict post-dialysis volume overload status in maintenance hemodialysis patients (MHD) based on ...

Cancer-associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi-omics and machine learning analysis.

Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. T...

Integrated Single-Cell and Bulk Transcriptome Analysis Reveals the Prognostic Significance and Immune Regulatory Mechanisms of Sialylation in Hepatocellular Carcinoma.

Liver Hepatocellular Carcinoma (LIHC) is a high-mortality primary liver cancer. Its treatment and prognosis are highly dependent on disease stage and ...

Predicting mortality and short-term outcomes of continuous kidney replacement therapies in neonates and infants.

BACKGROUND: Continuous kidney replacement therapy (CKRT) has emerged as a valuable treatment option in critically ill neonates and infants with acute ...

IntelliScheduler: an edge-cloud computing environment hybrid deep learning framework for task scheduling based on learning.

Edge-cloud computing has emerged as an important paradigm for modern Internet of Things (IoT) workflow applications, enabling low latency and on-deman...

UHRF2 related to sumoylation : assessment of its role in immune suppression and therapeutic potential in colorectal cancer.

SUMOylation is a critical post-translational modification of proteins. However, the roles of SUMOylation-related genes in regulating the tumor immune ...

CXCL9 as a key feature for deep learning-based immune subtyping and prediction of immune checkpoint blockade response in triple-negative breast cancer.

BACKGROUND: Immune checkpoint blockade (ICB) therapy has provided a promising treatment option for patients with triple-negative breast cancer (TNBC)....

Association between hypothermic machine perfusion parameters and graft function in deceased donor kidney transplantation.

BACKGROUND: Kidney transplantation (KT) is the most effective treatment for end-stage renal disease. Hypothermic machine perfusion (HMP) can improve r...