Latest AI and machine learning research in kidney transplantation for healthcare professionals.
Intratumoral heterogeneity (ITH) is a fundamental driver of clonal evolution and therapeutic resistance in gastric cancer (GC). However, the clinical assessment of ITH remains limited by the high cost and technical complexity of multi-region and single-cell sequencing. This study aimed to develop a pathomics-deep learning (DL) fusion model for estimating ITH directly from routine H&E-stained whole...
BACKGROUND: Colorectal cancer (CRC) exhibits substantial metabolic heterogeneity. This study developed a robust prognostic signature integrating ferroptosis- and lipid metabolism-related genes to investigate the role of CRY2 in CRC progression. METHODS: Transcriptomic and clinical data from the TCGA-COAD and GSE39582 cohorts were analyzed. Weighted gene co-expression network analysis (WGCNA) was p...
AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poor prognosis, extensive perineural invasion (PNI), ...
Glioma stem cells (GSCs) drive tumor heterogeneity, therapy resistance, and immunosuppression. This study identified molecular subtypes of glioma base...
OBJECTIVES: The pharmaco-epidemiological research program in kidney transplantation (PERP-KT) aims to evaluate, for the principal maintenance immunosu...
Rapid AI integration has introduced novel psychosocial stressors. Little is known about AI-specific clinical impacts in resource-limited settings. Thi...
Hepato-biliary-pancreatic cancers, notorious for their pronounced heterogeneity and poor prognosis, continue to be a dominant factor in cancer-related...
BACKGROUND: Colorectal cancer (CRC) displays considerable heterogeneity in clinical outcomes, highlighting the need for reliable prognostic biomarkers...
AIM: Tumor heterogeneity, driven by metabolic reprogramming, challenges colorectal cancer (CRC) treatment. Methionine metabolism is crucial for tumor ...
Colorectal cancer liver metastasis (CRLM) represents the leading cause of mortality in colorectal cancer (CRC). However, the molecular mechanisms enab...
BACKGROUND: Autoimmune hepatitis (AIH) is an important indication for liver transplantation (LT), but recurrence affects over 30% of recipients, threa...
Age-related macular degeneration (AMD) remains a leading cause of irreversible blindness worldwide, characterized by the progressive breakdown of the ...
Breast cancer remains a leading cause of cancer-related mortality in women, and current prognostic models are suboptimal. The transcriptomic role of p...
INTRODUCTION: Blood gas analysis is routinely performed in hemodialysis patients to monitor acid-base status and serum potassium. Despite frequent tes...
BACKGROUND: Artificial intelligence (AI) is increasingly integrated into scientific publishing workflows, yet no study has formally evaluated the abil...
Bladder cancer (BC) exhibits profound molecular heterogeneity and a highly dynamic tumor microenvironment, posing major challenges for effective thera...
Despite advancements in therapeutic cancer vaccines, clinical translation has been hindered by limited efficacy, with Sipuleucel-T remaining the only ...
Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at any age but preferentially affects adults aged 30 ...
Keratins (KRTs) are intermediate filament proteins expressed in epithelial cells and serve as diagnostic cancer biomarkers. They serve pivotal roles i...
Immunotherapy has revolutionized the treatment landscape of breast cancer, particularly for triple-negative breast cancer (TNBC), yet primary and acqu...