Leukemia

The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.

BACKGROUND: Sarcopenia has been proved to be associated with cardiovascular diseases, chronic kidney disease, and metabolic disorders, but the relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. PURPOSE: To investigate the relationship between sarcopen...

Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.

BACKGROUND: Survival outcomes after transarterial chemoembolisation (TACE) vary in hepatocellular carcinoma (HCC) patients, and existing prognostic scores and imaging models often lack generalisability and biological interpretability. OBJECTIVE: To develop and validate a multimodal prognostication model for HCC that allows for a precise assessment of survival outcomes of HCC patients receiving TAC...

Explainable artificial intelligence for personalized prognosis in pancreatic cancer: A nationwide study from Taiwan.

Pancreatic cancer is highly aggressive with poor outcomes; current artificial intelligence (AI) prognostic models often lack interpretability and unde...

MOTDNet: Multi organ task decoupling network for cell segmentation.

In histopathology, cell detection and segmentation of Hematoxylin and Eosin (H&E) stained tissue images are essential clinical tasks. Existing methods...

Structural and dynamic characterization of papain-like protease ligand recognition using integrated computational and biochemical approaches.

The papain-like protease (PLpro) is a structurally conserved cysteine protease whose catalytic activity and regulatory functions are governed by a wel...

Thymic health and immunotherapy outcomes in patients with cancer.

Although immunotherapy has revolutionized cancer treatment, many patients still experience limited benefit, highlighting the urgent need for improved ...

Veteran oropharyngeal cancer outcomes in the modern era: a multi-institutional retrospective analysis.

OBJECTIVE: To define oncologic outcomes in Veterans in the modern era using a multi-institutional cohort designed to support development and validatio...

Identification of hypoxia-related gene signatures and molecular subtypes in chronic rhinosinusitis with nasal polyps.

OBJECTIVES: Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a common and severe subtype of Chronic Rhinosinusitis (CRS), characterized by persist...

Rapid detection of drug-resistant leukemia cell using an optofluidic chip and machine learning.

BACKGROUND: Rapid detection of drug-resistant leukemia played a crucial role in formulating appropriate treatment plans for patients and improving the...

Molecular and Pharmacogenetic Marker Evaluation in Relation to the Toxicity and Clinical Response of Acute Lymphoblastic Leukemia Treatment in Indian Children (MPGx-INDALL): Protocol for a Prospective Observational Cohort Study.

BACKGROUND: Understanding interindividual variability in treatment response and toxicity is essential for optimizing outcomes in pediatric acute lymph...

Comparison of Left Ventricular Ejection Fraction Among 18F-FDG Dual-Gated PET/CT, Single-Gated PET/MRI, and Cardiac MRI.

Left ventricular ejection fraction (LVEF) is a critical parameter in the evaluation of cardiac function, and its measurement can guide treatment decis...

scCAPReSE: detection of large-scale genomic rearrangements from single-cell Hi-C based on few-shot learning.

Large-scale genomic rearrangements are prevalent in cancer genomes and can profoundly rewire three-dimensional (3D) genome architecture, leading to ab...

Artificial intelligence-based analysis of thrombotic and infectious risk factors in peripherally inserted central catheters (PICCs).

INTRODUCTION: Peripherally inserted central catheters (PICCs) are increasingly used in France for prolonged intravenous therapies such as chemotherapy...

SPIN: Inkjet-Driven Nanowell Workflow for Scalable and Sensitive Single-Cell Proteomics.

Single-cell proteomics is emerging as a powerful approach to resolve cellular heterogeneity, yet sample processing remains challenging due to limited ...

A complete blood count-based machine learning model for rapid differentiation of aplastic anemia, immune thrombocytopenia, and myelodysplastic syndromes in routine clinical practice.

BACKGROUND: Accurate differentiation of common hematologic disorders remains challenging in routine clinical practice and often requires invasive diag...

Development and temporal validation of an interpretable point score for in-hospital mortality in CLL/SLL using the U.S. National Inpatient Sample, 2016-2022.

In-hospital mortality among patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is ∼6%, yet no validated, transparent beds...

Integrative transcriptomic and machine learning analysis identifies core immune genes and pathways driving graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

BACKGROUND: Graft-versus-host disease (GVHD), a major adverse event following allogeneic hematopoietic stem cell transplantation (allo-HSCT), commonly...

CRMIPred: Identifying the spatial interactions among cis-regulatory modules via considering their cross-attended epigenetic profiles.

BACKGROUND AND OBJECTIVE: Modular DNA elements known as cis-regulatory modules (CRMs) play central roles in transcriptional regulation in metazoan spe...

CT-based radiomics for predicting the treatment response to PD-1/PD-L1 inhibitors combined with chemotherapy in unresectable gastric cancer.

OBJECTIVE: To develop and validate a CT-based radiomics model to predict immunotherapy response in unresectable gastric cancer and explore its underly...

Complete Blood Count-Derived Inflammation Indices to Predict 3-Year All-Cause Mortality in Patients With Diabetes and Acute Myocardial Infarction in Critical Care: Retrospective Cohort Study With Single-Center External Validation.

BACKGROUND: Inflammation plays a pivotal role in the progression of diabetes and its cardiovascular complications, particularly acute myocardial infar...