Hematology

Leukemia

Latest AI and machine learning research in leukemia for healthcare professionals.

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Domain-adversarial learning predicts clinically actionable drug combination synergy in leukemia patients using bulk transcriptomics data

Deep learning has gained popularity in drug combination synergy prediction; however, DL models requi...

Transcript architecture predetermines m6A remodeling and sensory neuron vulnerability in chemotherapy-induced peripheral neuropathy

Whether individual transcripts carry intrinsic features that predetermine their response to external...

Plasmatic immune extracellular vesicle profiles identify prodromal and early stages of Parkinson's disease

Extracellular vesicles (EVs) hold promise as minimally invasive biomarkers for neurodegenerative pro...

Predicting Response to Neoadjuvant Chemotherapy in Ovarian Cancer from CT Baseline Using Multi-Loss Deep Learning

Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an...

Generative machine learning unlocks the first proteome-wide image of human cells

The spatial organization of proteins within cells governs virtually all cellular functions. Yet, cur...

PRISM: Perinuclear Ring-based Image Segmentation Method for Acute Lymphoblastic Leukemia Classification

Automated analysis of peripheral blood smears for Acute Lymphoblastic Leukemia (ALL) is hindered by ...

Kinome profiling allows examination and prediction of kinase inhibitor cardiotoxicity

Background: Despite improved cancer outcomes with kinase inhibitors (KIs), their cardiotoxicity rema...

Mechanistic learning to predict and understand minimal residual disease

Mechanistic modeling has long been used as a tool to describe the dynamics of biological systems, es...

Recurrent Deep Reinforcement Learning for Chemotherapy Control under Partial Observability

Chemotherapy dose optimization can be formulated as a dynamic treatment regime, requiring sequential...

Biological Spatial Priors Regularize Foundation Model Representations for Cross-Site MSI Generalization in Colorectal Cancer

Predicting microsatellite instability (MSI) status from routine hematoxylin and eosin (H&E) whole sl...

Privacy-Preserving Federated Learning via Differential Privacy and Homomorphic Encryption for Cardiovascular Disease Risk Modeling

Protecting sensitive health data while enabling collaborative analysis is a central challenge in hea...

KAYRA: A Microservice Architecture for AI-Assisted Karyotyping with Cloud and On-Premise Deployment

We present KAYRA, an end-to-end karyotyping system that operates inside the operational constraints ...

Aycromo: An Open-Source Platform for Automatic Chromosome Detection in Metaphase Images Based on Deep Learning

Chromosome analysis is a fundamental step in the diagnosis of genetic diseases, but the manual karyo...

On the predictability of progression-free survival in ovarian cancer from NanoString gene expression data

In the treatment of high grade serous ovarian cancer (HGSC), patients initially diagnosed with unres...

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