Hematology

Leukemia

Latest AI and machine learning research in leukemia for healthcare professionals.

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Tahoe-x1: Scaling Perturbation-Trained Single-Cell Foundation Models to 3 Billion Parameters

Foundation models have transformed natural language processing and computer vision, yet their potent...

KSMoFinder - Knowledge graph embedding of proteins and motifs for predicting kinases of human phosphosites

Protein kinases regulate cellular signaling pathways through a cascade of phosphorylation activity, ...

Single-cell RNA sequencing and large-scale bulk combination with machine learning reveal gastric cancer-related macrophage heterogeneity

The tumor microenvironment (TME) significantly impacts cancer progression and overall patient surviv...

RoBep: A Region-Oriented Deep Learning Model for B-Cell Epitope Prediction

Accurate in silico identification of B-cell epitope residues is crucial for antibody design and stru...

Systematic discovery of single-cell protein networks in cancer with Shusi

Context-specific protein-protein interaction (PPI) drive heterogeneity of primary tumor, forming a f...

CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants

Genomic selection (GS), which integrates genomic markers with phenotypic data, has emerged as a powe...

Grid to Place Cell Connectivity in Eleven Different Rooms

To understand the grid to place cell connectivity, we took place cell firing data from the Moser lab...

Language may be all omics needs: Harmonizing multimodal data for omics understanding with CellHermes

Decoding cellular systems requires integrating diverse omics data, yet most models are trained from ...

Assessing Scale and Predictive Diversity in Models for Single-Cell Transcriptomics based on Geneformer

Foundation models are increasingly applied to single-cell transcriptomics, where they promise to cap...

Software system design to support scale in mammalian cell line engineering

Cell line engineering (CLE) is the process of gene editing cell lines for a variety of purposes for ...

ECLIPSE: Exploration of Complex Ligand-Protein Interactions through Learning from Systems-level Heterogeneous Biomedical Knowledge Graphs

Discovering new, efficacious molecules remains slow and costly; rigorous data science-driven systems...

Deep Learning links TP53 genotype to expression-defined transcriptional program in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a hematological cancer characterized by genetic diversity and poor c...

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation

Extracellular vesicles (EVs) mediate tumor-immune cell communication by carrying protein cargo that ...

Beyond one-size-fits-all: single-cell transcriptomic signatures predict drug efficacy and reveal responder subgroups in endometriosis

Endometriosis affects ∼10% of reproductive-age women, yet targeted non-hormonal therapies remain una...

A comprehensive bulk and single-cell transcriptional atlas of pediatric leukemias

Advancements in understanding the molecular factors driving pediatric leukemias have led to an ever-...

Social isolation upregulates takeout expression in female Drosophila melanogaster to promote sucrose feeding

Drosophila melanogaster provides a model system to examine how environmental stress interacts with s...

Classpose: foundation model-driven whole slide image-scale cell phenotyping in H&E

Cell segmentation and phenotyping in histopathology samples are essential techniques applied across ...

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