Leukemia

Integrated bulk and single-cell transcriptomic analysis reveals the impact of lactate-related genes on prognosis and immune characteristics in HNSCC.

Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis, accompanied by metabolic reprogramming and tumor microenvironment (TME) disorders. Lactate metabolism is critical for tumor progression and immune escape, but its regulatory mechanism and clinical value in HNSCC remain unclear. We integrated single-cell and bulk RNA-sequencing data to identify l...

Reframing Response in Neoadjuvant Chemotherapy for Ovarian Cancer: Integrating Molecular and Functional Biomarkers.

BACKGROUND: Neoadjuvant chemotherapy (NACT) is an established treatment strategy for advanced epithelial ovarian cancer, particularly for patients with high tumour burden or poor surgical fitness. Despite improvement in resectability and reducing perioperative morbidity, current methods for evaluating response, namely imaging, serum biomarkers and histopathology, lack sensitivity and fail to provi...

Chemical features consistently associated with kinase inhibitor activity: a cross-target SHAP analysis under scaffold-split evaluation.

Interpretable machine learning approaches to quantitative structure-activity relationship (QSAR) modelling are increasingly applied in drug discovery,...

Topological imaging of single-cell CAF heterogeneity for predicting prognosis and adjuvant chemotherapy benefit in pancreatic cancer.

PURPOSE: Cancer-associated fibroblasts (CAFs) are central drivers of PDAC progression and therapeutic resistance, yet their preoperative clinical util...

Artificial Intelligence-Based CTA Software for Real-World Detection of Large Vessel Occlusion in Acute Ischemic Stroke.

Background and purpose Artificial intelligence (AI)-based tools for CT angiography (CTA) have been introduced to support rapid detection of large vess...

Antibody-drug conjugates in selected solid tumours: a position statement update based on findings from the third workshop held by the ETOP IBCSG Partners Foundation.

The European Thoracic Oncology Platform (ETOP) International Breast Cancer Study Group (IBCSG) Partners Foundation initiated a series of workshops for...

Anthropometry-adjusted TyG indices predict diabetes, graft failure, and mortality in kidney transplant recipients.

CONTEXT: The triglyceride-glucose (TyG) index is a widely used surrogate marker of insulin resistance and associated with cardiometabolic outcomes. Ho...

LWF-YOLO: a lightweight framework based YOLO for blood cell detection.

Accurate detection of blood cells-red blood cells, white blood cells, and platelets-is essential for diagnosing hematological disorders such as anemia...

AI-Optimized 3D-Printed Dual-Layer Implant: Resolving Chemo-Immunotherapy Sequential Administration Dilemma for Colorectal Cancer Peritoneal Metastasis.

The synergistic integration of chemotherapy and immunotherapy represents the most promising strategy for enhancing therapeutic efficacy in cancer trea...

Time-dependent radiological risk assessment following a severe NPP accident using Monte Carlo simulation, BEIR VII, and interpretable AI.

Nuclear reactor accidents can result in prolonged radiation exposure with complex and uncertain health consequences. Existing studies often focus on d...

Development and validation of a disease-syndrome integrated assessment model for AECOPD severity: protocol for a nationwide multicentre cross-sectional study.

INTRODUCTION: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) accelerate disease progression and increase mortality. Accurate se...

Personalized antiplatelet therapy: are we ready for a precision medicine approach.

Dual antiplatelet therapy (DAPT), combining aspirin with a P2Y12 inhibitor, remains central to secondary prevention after acute coronary syndrome and ...

Development and validation of a novel multimodal deep neural network model based on CBC digit parameters and scattergrams for rapid hematolymphoid malignancy classification: a multicenter cohort study.

BACKGROUND: Rapid screening of hematolymphoid malignancies (HMs) by complete blood cell count (CBC) is crucial for choosing the next appropriate worku...

Unveiling the identification of the genetic features and biological characteristics shared between cervical cancer and venous thromboembolism.

OBJECTIVE: The association between cervical cancer (CC) and venous thromboembolism (VTE) has been well documented, but the underlying molecular charac...

Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions.

Analysis of multimodal and multidimensional data capturing dynamic interactions between diverse cell populations is a current challenge in bioimaging,...

Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) by influencing tumor progression, metastasis, and therapy...

SpiderMass ambient mass spectrometry and multimodal machine learning enable ex vivo ovarian cancer typing and exploratory immunoscoring.

Complete cytoreductive surgery remains one of the strongest determinants of outcome in ovarian cancer, yet surgeons still lack rapid tissue-assessment...

Maxillary Anterior Horizontal Ridge Reconstruction using Computer-Guided Ridge Split and Expansion: A Randomized Clinical Trial with a 2-Year Follow-up.

OBJECTIVES: This randomized clinical study aimed to assess implant placement accuracy and radiographic outcomes of computer-guided versus freehand rid...

Anatomically Localized Detection of Six Acute Abdominal Emergencies on CT Using Multi-window Deep Learning: Development and Validation.

The purpose of this study is to develop and retrospectively validate a deep learning system for the classification and anatomically interpretable loca...

Integrated transcriptomic and experimental validation reveal that N‑acetylcysteine ameliorates acute liver failure through multi‑target synergistic regulation of pyroptosis and related signaling networks.

Pyroptosis is a major contributor to the pathophysiology of acute liver failure (ALF), a condition with high mortality. Although N‑acetylcysteine (NAC...