Oncology/Hematology

Lung Cancer

Latest AI and machine learning research in lung cancer for healthcare professionals.

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Persistent Homology and Gabor Features Reveal Inconsistencies Between Widely Used Colorectal Cancer Training and Testing Datasets

Recent work on computer vision and image processing has relied substantially on open datasets, which allow for an objective comparison of techniques and methodologies. In the area of computational pathology and, more specifically, on colorectal cancer, the dataset NCT-CRC-HE-100K, which consists of 100,000 patches of human tissue stained with Haematoxylin and Eosin has been widely used as a traini...

A Fusion-Based Multiomics Classification Approach for Enhanced Gene Discovery in Non-Small Cell Lung Cancer

This study introduces a fusion-based multiomics approach to identifying non-small cell lung cancer (NSCLC)-relevant genes. We evaluated the NSCLC-subtype classification performance of various state-of-the-art machine learning models using single omics and fused multiomics approaches. The models were trained separately on individual omics data sets. Subsequently, a weighted-average-based decision-l...

Deep learning NTCP model for late dysphagia after radiotherapy for head and neck cancer patients based on 3D dose, CT and segmentations

Late radiation-associated dysphagia after head and neck cancer (HNC) significantly impacts patient’s health and quality of life. Conventional normal t...

Detecting neurodegenerative changes in glaucoma using deep mean kurtosis-curve–corrected tractometry

Glaucoma is increasingly recognized as a neurodegenerative condition involving both retinal and central nervous system structures. Here, we present an...

Decoding the JAK-STAT axis in colorectal cancer with AI-HOPE-JAK-STAT: A conversational artificial intelligence approach to clinical-genomic integration

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is a critical mediator of immune regulation, inflammati...

Clinical-grade autonomous cytopathology via whole-slide edge tomography

Cytopathology plays a central role in the early detection of cancers such as cervical, lung, and bladder cancer due to its speed, simplicity, and mini...

Evaluation of Large Language Model-Generated Patient Information for Communicating Radiation Risk

Large language models are increasingly used to generate patient information in healthcare. However, their ability to communicate complex topics, such ...

Large Language Model-Based Entity Extraction Reliably Classifies Pancreatic Cysts and Reveals Predictors of Malignancy: A Cross-Sectional and Retrospective Cohort Study

Pancreatic cystic lesions (PCLs) are often discovered incidentally on imaging and may progress to pancreatic ductal adenocarcinoma (PDAC). PCLs have a...

DeepSpot: Leveraging Spatial Context for Enhanced Spatial Transcriptomics Prediction from H&E Images

Spatial transcriptomics technology remains resource-intensive and unlikely to be routinely adopted for patient care soon. This hinders the development...

AI-based Hepatic Steatosis Detection and Integrated Hepatic Assessment from Cardiac CT Attenuation Scans Enhances All-cause Mortality Risk Stratification: A Multi-center Study

Hepatic steatosis (HS) is a common cardiometabolic risk factor frequently present but under-diagnosed in patients with suspected or known coronary art...

SuReCAN: a suite of user-friendly Galaxy machine learning workflows to predict survival and treatment response of cancer patients

Cancer is one of the leading lethal causes worldwide, with enormous impact on healthcare, economy and society. One of the main challenges of clinical ...

Artificial Intelligence (AI)-Powered H&E Whole-Slide Image Analysis of Tertiary Lymphoid Structure (TLS) Independently Predicts Survival in Patients with Non-Small Cell Lung Cancer (NSCLC) Receiving Immunotherapy

Tertiary lymphoid structures (TLSs) within the tumor microenvironment have emerged as potential indicators of treatment response to immune checkpoint ...

Risk Prediction Modelling of 30-day all-cause mortality following percutaneous coronary intervention in an Australian population: Leveraging Machine Learning

Pre-procedural risk prediction of 30-day all-cause mortality after percutaneous coronary intervention (PCI) aids in clinical decision-making and bench...

Predicting overall survival of NSCLC patients with clinical, radiomics and deep learning features

Accurate estimation of Overall Survival (OS) in Non-Small Cell Lung Cancer (NSCLC) patients provides critical insights for treatment planning. While p...

Large Language Models Improve Cancer Survival Prediction Using Real-World Clinical Notes

In medical documentation, vast amounts of unstructured text are generated that are still underutilized in current prognostic models. We investigate th...

Deep Learning-Assisted Skeletal Muscle Radiation Attenuation at C3 Predicts Survival in Head and Neck Cancer

Head and neck cancer (HNC) patients face an increased risk of malnutrition due to lifestyle, tumor localization, and treatment effects. While skeletal...

Causal Machine Learning Analysis of All-Cause Mortality in Japanese Atomic-Bomb Survivors

The health consequences of ionizing radiation have long been studied, yet significant uncertainties remain, particularly at low doses. In particular, ...

Revealing Shared Tumor Microenvironment Dynamics Related to Microsatellite Instability Across Different Cancers Using Cellular Social Network Analysis

Microsatellite instability (MSI) is a key biomarker for immunotherapy response and prognosis across multiple cancers, yet its identification from rout...

Development of a RAG-based Expert LLM for Clinical Support in Radiation Oncology

The ability of pre-trained large language models (LLMs) to rapidly master novel natural language processing tasks holds transformative potential. Howe...

Deep Learning-Identified Clinical Trajectory Patterns and Associations with Kidney Outcomes in IgA Nephropathy

The heterogeneous course of IgA nephropathy limits risk stratification based on static markers. We sought to identify clinical trajectory subgroups us...

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