Rheumatology

Lupus

Latest AI and machine learning research in lupus for healthcare professionals.

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Showing 1041-1060 of 1,738 articles

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework.

Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data. Here, we propose scPrediXcan, which integrates state-of-the-art deep learning approaches that predict epigenetic features from DNA sequences with the canonical T...

May 14 2025 40373737

Computational Analysis using Multi-ligand Simultaneous Docking of Withaferin A and Garcinol Reveals Enhanced BCL-2 and AKT-1 Inhibition

Developing an effective medicine to combat cancer and elusive stem cells is crucial in the current scenario. Withaferin A and Garcinol, important phytoconstituents of Withania somnifera (Ashwagandha) and Garcinia indica (Kokum) respectively, known for their therapeutic efficiency, have been used for several decades for treating various disorders, because of their anti-cancerous, anti-inflammator...

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells.

Despite the success of BCMA-targeting CAR-Ts in multiple myeloma, patients with high-risk cytogenetic features still relapse most quickly and are in u...

May 13 2025 40359480
Single-cell and spatial transcriptomics reveals an anti-tumor neutrophil subgroup in microwave thermochemotherapy-treated lip cancer.

Microwave thermochemotherapy (MTC) has been applied to treat lip squamous cell carcinoma (LSCC), but a deeper understanding of its therapeutic mechani...

May 13 2025 40360503
Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features.

Tests that can predict whether a drug is likely to extend mouse lifespan could speed up the search for anti-aging drugs. We have applied a machine lea...

May 12 2025 40462916
Fusogenic Lipid Nanovesicles as Multifunctional Immunomodulatory Platforms for Precision Solid Tumor Therapy.

Although immunotherapy demonstrates considerable prospect in overcoming solid tumors, its clinical efficacy is limited by several factors, such as poo...

May 12 2025 40351077
Blood-brain barrier crossing biopolymer targeting c-Myc and anti-PD-1 activate primary brain lymphoma immunity: Artificial intelligence analysis.

Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor response to pharmacological treatment, partially du...

May 10 2025 40088978
Dendritic cell-based microrobots for enhanced systemic antigen-specific immune tolerance.

Current immunotherapeutic approaches for autoimmune disorders primarily rely on the use of generalized immunosuppressive medications. However, most im...

May 10 2025 40010412
Deep learning-enhanced anti-noise triboelectric acoustic sensor for human-machine collaboration in noisy environments.

Human-machine voice interaction based on speech recognition offers an intuitive, efficient, and user-friendly interface, attracting wide attention in ...

May 8 2025 40341503
Learning Unknown Spoof Prompts for Generalized Face Anti-Spoofing Using Only Real Face Images

Face anti-spoofing is a critical technology for ensuring the security of face recognition systems. However, its ability to generalize across diverse...

Multi-Scale Graph Learning for Anti-Sparse Downscaling

Water temperature can vary substantially even across short distances within the same sub-watershed. Accurate prediction of stream water temperature ...

Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning.

OBJECTIVES: EBV is a widespread virus implicated in various diseases, including SLE. However, the specific genes and pathways altered in SLE patients ...

May 1 2025 39361430
Susana Vázquez Torres: the power of computational protein design.

Susana Vázquez Torres talks to Ana Lesher Treviño about AI-guided protein design for antivenoms and her aim to improve access to lifesaving treatments...

May 1 2025 40342853
Group Downsampling with Equivariant Anti-aliasing

Downsampling layers are crucial building blocks in CNN architectures, which help to increase the receptive field for learning high-level features an...

Privacy Protection Against Personalized Text-to-Image Synthesis via Cross-image Consistency Constraints

The rapid advancement of diffusion models and personalization techniques has made it possible to recreate individual portraits from just a few publi...

Anti-Aesthetics: Protecting Facial Privacy against Customized Text-to-Image Synthesis

The rise of customized diffusion models has spurred a boom in personalized visual content creation, but also poses risks of malicious misuse, severe...

Detecting Stereotypes and Anti-stereotypes the Correct Way Using Social Psychological Underpinnings

Stereotypes are known to be highly pernicious, making their detection critically important. However, current research predominantly focuses on detec...

Unsupervised Feature Disentanglement and Augmentation Network for One-class Face Anti-spoofing

Face anti-spoofing (FAS) techniques aim to enhance the security of facial identity authentication by distinguishing authentic live faces from decept...

Deep Learning-Based Quantitative Assessment of Renal Chronicity Indices in Lupus Nephritis

Background: Renal chronicity indices (CI) have been identified as strong predictors of long-term outcomes in lupus nephritis (LN) patients. However,...

SLIP: Spoof-Aware One-Class Face Anti-Spoofing with Language Image Pretraining

Face anti-spoofing (FAS) plays a pivotal role in ensuring the security and reliability of face recognition systems. With advancements in vision-lang...

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