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Medicolegal

Latest AI and machine learning research in medicolegal for healthcare professionals.

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NEXIM: A Nash Equilibrium-Based Framework for Stable Explainable AI in Medical Applications

Reliable explanations are important for trustworthy medical applications of artificial intelligence (AI), but attribution-based explanations can vary across model randomization and small analytic changes. We present NEXIM (Nash Equilibrium-based Explainability and Interpretability Model), implemented here as an accuracy-constrained, equilibrium-inspired model-selection framework that jointly evalu...

Automated Multisource Electronic Frailty Index in Acute Ischemic Stroke: Development and Clinical Utility

Background: Frailty is common in acute ischemic stroke (AIS) and predicts poor outcomes, but is not routinely captured in acute stroke care. Manual frailty tools are difficult to apply consistently in busy inpatient settings, while existing electronic frailty indices (eFIs) often rely on limited data modalities. We developed a scalable pre-stroke electronic frailty index (eFI) using multisource el...

AI as a signal assessor - Can a Large Language Model perform causality assessment on a case series?

Background Large Language Models (LLMs) are increasingly explored for pharmacovigilance tasks, including information extraction, case documentation, a...

A Natural Experiment Reveals Clinically Essential and Compliance-Driven Nursing Documentation

Despite contributing substantially to clinician burnout, nursing documentation lacks empirical evidence distinguishing clinically essential from admin...

Multilingual Hematology Visual Question Answering Dataset

Vision Language Models (VLMs) have shown promising capabilities in medical image analysis by jointly understanding visual and textual information for ...

Jun 24 2026 2606.25246v1
Symptom-based phenotype discovery in motor neuron disease using natural language processing of electronic health records

Background: Motor neuron disease (MND) is a fatal neurodegenerative condition with significant clinical heterogeneity that is incompletely captured by...

Extraction of Glaucoma Diagnosis, Type, and Severity from Clinical Notes using Secure Cloud-based Large Language Models

Purpose: To evaluate the performance of secure cloud-based large language models (LLMs) in extracting glaucoma diagnosis, type, and severity from free...

Personalizing Suicide Risk Assessment: Machine Learning Extraction of Cross-Modal Interactions Between Psychosocial and Demographic Factors in Veterans

Background: Veterans face an elevated risk of suicide compared to the general population, motivating national efforts to develop predictive models tha...

Comparative Evaluation of Pretrained Large Language Models for Suicide Risk Prediction from Clinical Notes in U.S. Veterans

Background: Suicide remains a significant and potentially preventable cause of death among United States veterans. Predictive models based on structur...

Language Models as Interfaces, Not Oracles: A Hybrid LLM-ML System for Pediatric Appendicitis

Large language models (LLMs) can make clinical decision support more accessible by interpreting free-text documentation, but their direct use as diagn...

Jun 17 2026 2606.19183v1
Adverse Childhood Experiences and Growth Outcomes in Childhood: A Longitudinal EHR-Based Study

Question Are adverse childhood experiences (ACEs) associated with altered growth trajectories in childhood? Findings In this cohort study of 412,549 c...

OmicOS: A Comprehensive Omics Ecosystem Infrastructure and Agent System for the AI Era

Biology has accumulated a vast ecosystem of omics methods, but much of this ecosystem remains built for expert humans rather than scientific agents. M...

The Slop Paradox: How Synthetic Standardization Erodes Clinical Uncertainty and Cross-Modal Alignment in AI-Rewritten Radiology Reports

AI-assisted clinical documentation tools increasingly summarize, standardize, and reformat radiology reports using large language models (LLMs). We pr...

Jun 16 2026 2606.17791v1
Seeing Is Not Screening: Multimodal Hidden Instruction Attacks on Agent Skill Scanners

Agent skills are emerging as an important attack surface in LLM-based systems. Through an empirical study of existing skill scanners, we find that cur...

Jun 16 2026 2606.18198v1
Medical Heuristic Learning: An LLM-Driven Framework for Interpretable and Auditable Clinical Decision Rules

Predictive modeling for clinical tabular data is central to clinical decision support and therefore requires not only strong predictive performance bu...

Jun 15 2026 2606.16337v2
Medical Heuristic Learning: An LLM-Driven Framework for Interpretable and Auditable Clinical Decision Rules

Predictive modeling for clinical tabular data is central to clinical decision support and therefore requires not only strong predictive performance bu...

Jun 15 2026 2606.16337v1
ADMETron: An AI-driven SaaS platform for comprehensive ADMET prediction and compound prioritisation

ONTOSIGHT(R) ADMETron is an AI-driven platform designed for rapid prediction and visualization of Absorption, Distribution, Metabolism, Excretion, and...

Gradient boosting for extremes: sampling theory and application to insurance

We develop a statistical learning theory for gradient boosting applied to the estimation of covariate-dependent Generalized Pareto (GP) distributions ...

Jun 12 2026 2606.14268v1
Comprehensive evaluation of LLM capabilities for interpretation and analysis of genome-scale metabolic models in metabolic engineering

Genome-scale metabolic models (GSMs) underpin pathway and strain engineering by linking genes to metabolic reactions and enabling system-level simulat...

Bridging Expert Knowledge and Automated Feature Engineering via Self-Evolution

In high-stakes settings such as brand compliance, clinical care, and content moderation, machine learning cannot be deployed as opaque oracles: practi...

Jun 7 2026 2606.08800v1
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