Endocrinology

Menopause

Latest AI and machine learning research in menopause for healthcare professionals.

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ViPSAM: Visual Prompting Medical Image Segmentation Using Segment Anything Model

In proton therapy planning, respiratory-gated non-contrast CT (NCCT) is commonly used for lesion segmentation; however, accurate delineation remains challenging due to low lesion-to-background contrast. Although learning-based methods have shown strong performance, they often struggle with non-contrast image segmentation. Inspired by clinical practice, where contrast-enhanced MRI is referenced to ...

Jul 15 2026 2607.14328v1

Machine Learning Models for Osteoporosis Prediction: A Systematic Review and Meta-Analysis

Purpose The application of machine learning (ML) to osteoporosis prediction has expanded rapidly, yet no comprehensive meta-analysis has synthesized the discriminative performance of these models across all ML categories, data types, and validation strategies. This systematic review and meta-analysis aimed to evaluate the diagnostic and predictive accuracy of ML and deep learning models for osteop...

Generative AI Models Reveal Dynamic Views of Aging (DyViA) Phenotypes in Healthy Individuals

Background and objectives: In recent years, the need to develop analytical strategies for healthy aging has assumed great importance. In this study, w...

Multimodal profiling for prediction of primary resistance to anti-PD-(L)1 therapy in advanced non-small-cell lung cancer: the prospective PIONeeR biomarkers study

Background Pretreatment prediction of primary resistance to anti-PD-(L)1 therapy in advanced non-small-cell lung cancer (NSCLC) remains an unmet clini...

Decoding the regulatory genetic architecture of endometriosis using AlphaGenome

Background Endometriosis is a complex, estrogen-dependent disease with a strong genetic component. Although genome-wide association studies (GWAS) hav...

GEAR: Guided End-to-End AutoRegression for Image Synthesis

Visual generative models are typically trained in two stages. A tokenizer is first trained for reconstruction and then frozen, after which a generator...

Jun 30 2026 2606.32039v1
Promise and challenges of heart chamber segmentation from non-contrast CT scans using contrastive unpaired image translation: a feasibility study

Purpose: To evaluate the feasibility and challenges of heart chamber segmentation from non-contrast CT scans using contrastive unpaired image translat...

Jun 22 2026 2606.23879v1
Foundation Models for Epileptogenic Zone Identification in Drug-Resistant Epilepsy

Accurate identification of the epileptogenic zone (EZ) is essential for seizure freedom after resective surgery in drug-resistant epilepsy, yet seizur...

Jun 21 2026 2606.22657v1
Hard to Halt: Automation Bias in Agent-Driven Sequencing Prior Authorization Workflows

Purpose: Prior authorization (PA) for exome or genome sequencing is a time-consuming process that impedes timely rare disease diagnosis. Large languag...

Buffered sweat microfluidics with AI-enabled translation for clinically actionable blood urea estimation and renal risk stratification

Kidney-function assessment relies on blood urea as a clinically informative metabolic marker; however, its dependence on venipuncture and centralised ...

Silent Manipulation of Mental Health Treatment Recommendations from a Large Language Model

Importance. Large language models (LLMs) increasingly inform mental health decisions by patients and clinicians. Inference-time activation steering ca...

AI-assisted continuous-time modelling of metastatic breast cancer reveals subtype-specific spatiotemporal organ interactions

Metastatic breast cancer is one of the leading causes of premature mortality among women worldwide. A major barrier to optimal care is the marked hete...

Surprise-Guided MergeSort: Budget-Efficient Human-in-the-Loop Ranking via Adaptive Comparison Scheduling

Pairwise comparison is the gold standard for subjective ranking tasks; however, exhaustive annotation requires a massive number of human comparisons (...

Jun 14 2026 2606.15623v1
A Deep Hypergraph Learning Model for Predicting Antimicrobial Combination Effects Across Bacterial Targets

Antimicrobial resistance (AMR) creates an urgent need for efficient strategies to identify effective antibacterial combinations. Combination therapy, ...

Seeing Below the Limit of Detection: A Censored-Poisson Bayesian Latent-Growth Change-Point Detector (the Span Detector) for Serial ctDNA in HR+/HER2- Metastatic Breast Cancer

Circulating-tumour DNA (ctDNA) carries evidence of drug resistance months before imaging shows it, but the earliest evidence lives below the assay's l...

Jun 10 2026 2606.11876v1
How Seemingly Inconsequential Design Choices Dictate Performance of LLMs in Pathology

General-purpose large language models (LLMs) are routinely used as baselines when evaluating specialized pathology models on whole-slide images (WSIs)...

Jun 10 2026 2606.12407v1
Democratising Camera Trap AI: An Open-Source Model for Detecting UK Mammals

Camera traps have become a cornerstone of biodiversity monitoring, but the artificial intelligence that turns vast quantities of images into usable ec...

Jun 9 2026 2606.10940v1
Beyond natural amino acids: Extending immunogenicity risk assessment to non-canonical peptide drugs through chemical feature encoding

Peptide therapeutics are increasingly used to treat challenging diseases, but immunogenicity risks limit their clinical success. In silico tools enabl...

AnchorDiff: Training-Free Concept Grounding for MM-DiTs via Anchor-Based Graph Propagation

Multi-Modal Diffusion Transformers (MM-DiTs) encode rich representations for training-free concept grounding, but existing attention-based methods oft...

May 26 2026 2605.26460v1
AI-Driven SERS for Non-invasive and Label-Free Extracellular Vesicle Detection Across Cellular Origins in Tears and Sweat

Wearable sensing technology capable of point-of-care, continuous and non-invasive analysis of exosomes in biofluid such as tears and sweat is an essen...

May 25 2026 2605.25465v1
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