Endocrinology

Menopause

Latest AI and machine learning research in menopause for healthcare professionals.

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Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men.

BACKGROUND: Obesity has been associated with low testosterone (T) in adult males and in pubertal boys. Therapy for hypogonadism with exogenous T may lead to testicular atrophy and later infertility. Only a few studies have demonstrated that the Selective Estrogen Receptor Modulator (SERM) clomiphene citrate (CC), an estrogen receptor antagonist, increases T in obese hypogonadal men while preventin...

Nov 13 2015 26844009

Defective secretion of Prostaglandin F2α during development of idiopathic persistent corpus luteum in mares.

Five mares that developed idiopathic persistent corpus luteum (PCL) were compared with 5 mares with apparently normal interovulatory intervals (IOIs). Progesterone (P4) and a metabolite of prostaglandin F2α (PGFM) were assayed daily beginning on the day of ovulation (Day 0). Transition between the end of an initial progressive P4 increase and the beginning of a gradual decrease in P4 occurred on m...

Oct 28 2015 26773369
Putative cancer-initiating stem cells in cell culture models for molecular subtypes of clinical breast cancer.

Cancer-initiating stem cells (CISC) represent a minor subpopulation of heterogeneous breast cancer. CISC are responsible for the acquired resistance t...

Oct 6 2015 26788219
Predicting Response to Neoadjuvant Chemotherapy with PET Imaging Using Convolutional Neural Networks.

Imaging of cancer with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) has become a standard component of diagnosis and staging in o...

Sep 10 2015 26355298
Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands.

The magnitude of the investment required to bring a drug to the market hinders medical progress, requiring hundreds of millions of dollars and years o...

Sep 4 2015 26286148
Teriparatide for the rapid resolution of delayed healing of atypical fractures associated with long-term bisphosphonate use.

Bisphosphonates (BPs) are the most widely used drugs to treat osteoporosis. However, recent reports associated to long-term BPs use with atypical low-...

Aug 21 2015 27708978
Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation.

Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons ...

Jul 15 2015 26174069
CYP19A1 Genetic Polymorphisms rs4646 and Osteoporosis in Patients Treated with Aromatase Inhibitor-Based Adjuvant Therapy.

OBJECTIVE: Third-generation aromatase inhibitors (AI) are potent suppressors of aromatase activity. The aim of this study was to measure the incidence...

Jul 7 2015 27026757
Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins.

With growing abundance and awareness of endocrine disrupting compounds (EDCs) in the environment, there is a need for accurate and reliable detection ...

Jun 11 2015 25900664
Using swing resistance and assistance to improve gait symmetry in individuals post-stroke.

A major characteristic of hemiplegic gait observed in individuals post-stroke is spatial and temporal asymmetry, which may increase energy expenditure...

Jun 10 2015 26066783
Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.

BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppre...

Jun 8 2015 27136911
Effect of uterine size on fertility of lactating dairy cows.

There are multiple reasons for reduced fertility in lactating dairy cows. We hypothesized that one cause of reduced fertility could be the overall siz...

Jun 3 2015 26924681
Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide ...

May 26 2015 26011183
Recurrence quantification analysis and support vector machines for golf handicap and low back pain EMG classification.

The quantification of non-linear characteristics of electromyography (EMG) must contain information allowing to discriminate neuromuscular strategies ...

May 2 2015 26027794
Efficient prediction of progesterone receptor interactome using a support vector machine model.

Protein-protein interaction (PPI) is essential for almost all cellular processes and identification of PPI is a crucial task for biomedical researcher...

Mar 3 2015 25741764
Prediction and quantifying parameter importance in simultaneous anaerobic sulfide and nitrate removal process using artificial neural network.

The present investigation deals with the prediction of the performance of simultaneous anaerobic sulfide and nitrate removal in an upflow anaerobic sl...

Dec 20 2014 25523291
Predictors of schizophrenia spectrum disorders in early-onset first episodes of psychosis: a support vector machine model.

Identifying early-onset schizophrenia spectrum disorders (SSD) at a very early stage remains challenging. To assess the diagnostic predictive value of...

Aug 11 2014 25109600
ViPSAM: Visual Prompting Medical Image Segmentation Using Segment Anything Model

In proton therapy planning, respiratory-gated non-contrast CT (NCCT) is commonly used for lesion segmentation; however, accurate delineation remains c...

Jul 15 2026 2607.14328v1
Machine Learning Models for Osteoporosis Prediction: A Systematic Review and Meta-Analysis

Purpose The application of machine learning (ML) to osteoporosis prediction has expanded rapidly, yet no comprehensive meta-analysis has synthesized t...

Generative AI Models Reveal Dynamic Views of Aging (DyViA) Phenotypes in Healthy Individuals

Background and objectives: In recent years, the need to develop analytical strategies for healthy aging has assumed great importance. In this study, w...

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