Menopause

Divergent Excitability of GABAergic Neurons Derived from Bipolar Disorder Patients Shapes Energy Shifts of Network Dynamics, possibly mimicking mania and depression

Bipolar disorder (BD) is characterized by fluctuating mood states, yet the cellular and circuit-level mechanisms distinguishing lithium-responsive (LR) from non-responsive (NR) patients remain elusive. We derived dentate gyrus granule neurons and GABAergic interneurons from induced pluripotent stem cells (iPSCs) of BD patients stratified by lithium response, and from healthy controls. Using patch-...

Benchmarking large language models for cell-free RNA diagnostic biomarker discovery

Large-language models (LLMs) can parse vast amounts of data and generate executable code, positioning them as promising tools for the development of biomarkers and classifiers from high-throughput omics data. Here, we benchmarked six LLMs, OpenAI’s o3 and GPT-4o, Anthropic’s Claude Opus 4 and Claude 3.7 Sonnet, and Google’s Gemini 2.5 Pro and Gemini 2.0 Flash, for disease classification based on p...

Automated generation of personalized trajectories of aging phenotypes with DyViA-GAN

With a general increase in human lifespan, the need for technological advances to develop strategies for healthy aging has assumed great importance. I...

Study on Early pregnancy diagnosis in sows based on joint analysis of vaginal secretion metabolomics and machine learning

Metabolic transformations in female mammals throughout gestation manifest in the metabolite profiles of bodily fluids, potentially serving as biomarke...

AMICI: Attention Mechanism Interpretation of Cell-cell Interactions

Spatial transcriptomic data enable study of cell–cell communication, yet current analysis tools often fail to provide dynamic, interpretable estimates...

Highly Adaptive Conductive Polymer Electronics Enhance Neural Data and Learning Accuracy

Human skin, the body’s largest organ, plays a vital role in sensing and transmitting neuronal, mechanical, and biochemical signals, making it an essen...

IRCAS: a novel end-to-end approach to identify, rectify and classify comprehensive alternative splicing events in a transcriptome without genome reference

Alternative splicing (AS) is a fundamental post-transcriptional mechanism that amplifies proteomic diversity and enables adaptive responses across euk...

Machine-learning-based determination of sex-related bladder cancer biomarkers

Bladder cancer exhibits sex-specific behavior, occurring more frequently in males but progressing to advanced stages more commonly in females. The act...

Social isolation upregulates takeout expression in female Drosophila melanogaster to promote sucrose feeding

Drosophila melanogaster provides a model system to examine how environmental stress interacts with sex to induce changes in brain function and behavio...

Asymmetric Cross-Reactivity of Nuclear Receptors Reveals an Evolutionary Buffer Between Estrogen and Androgen Signaling

A comprehensive all-by-all receptor ligand affinity screen using Boltz-2, a deep learning framework for protein-ligand interaction prediction, reveals...

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer

Estrogen receptor alpha (ER) is an established oncogenic transcription factor in breast and endometrial cancer; however, more is known about the mecha...

Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex

Recent advances in deep brain stimulation (DBS) of the subcallosal cingulate (SCC) show promise in mitigating the symptoms of treatment-resistant depr...

Quantitative AI based on evolutionary computation and information theory combined with mathematical functions yields algorithmic RNA biomarkers from a randomized rheumatoid arthritis clinical trial, accurately predicting individual patient responses to anti-TNF treatment, to enable precision medicine

The routine derivation of novel biomarkers from therapeutic clinical trials to accurately predict individual patient’s responses, would be a significa...

Assessing Inflammatory Protein Biomarkers in COPD Subjects with and without Alpha-1 Antitrypsin Deficiency

Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT ...

SLaM Image Bank – a real-world diverse London cohort linking brain MRI to electronic mental health and dementia records for the development of clinical decision support tools using artificial intelligence

Rapid developments are occurring in artificial intelligence (AI) and machine learning (ML) applied to neuroimaging. To date, advances in this space ha...

Multi-resolution vision transformer model for skin cancer subtype classification using histopathology slides

Digital pathology has significantly advanced cancer diagnosis by enabling high-resolution visualisation and assessment of tissue specimens. However, t...

CT-based Osteoporosis Classification and Bone-Muscle Interaction Mapping Using Multiple Interpretable Machine Learning Models with the BMINet Framework

Osteoporosis progresses through stages characterized by declining bone mineral density, vertebral deterioration, and muscle atrophy, with bone-muscle ...

Exploring multidrug resistance patterns in community-acquired E. coli urinary tract infections with machine learning

While associations of antibiotic resistance traits are not random in multidrug-resistant (MDR) bacteria, clinically relevant resistance patterns remai...

The Impact of Negative Emotions on Adolescents’ Nonsuicidal Self-Injury Thoughts: An Integrated Application of Machine Learning and Multilevel Logistic Models

Non-Suicidal Self-Injury (NSSI) is a prevalent and complex behavior among adolescents, often linked to negative emotions such as loneliness, anxiety, ...

Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults

Depression is associated with alterations in immuno-metabolic biomarkers, but it remains unclear whether these alterations are limited to specific mar...