Cardiovascular

Metabolic Syndrome

Latest AI and machine learning research in metabolic syndrome for healthcare professionals.

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NVAITC AI Scientist: A Governed End-to-End Research System -- A Hypertension GWAS Case Study

Agentic research systems are emerging as a new paradigm for coordinating scientific workflows beyond isolated model inference, code generation, or statistical analysis. However, deployment in institutional biomedical environments requires governed mechanisms for research planning, data access, workflow orchestration, evidence tracking, reproducibility, and human oversight. We present NVAITC AI Sci...

Jul 13 2026 2607.11084v1

Effect of initiating an ARB- versus ACEI-based regimen on dementia risk, a target trial emulation of 2.5 million US Veterans

Background: Hypertension is a modifiable risk factor for dementia, yet the comparative effectiveness of angiotensin receptor blockers (ARBs) versus angiotensin converting enzyme inhibitors (ACEIs) on dementia risk remains uncertain. Objective: To compare the risk of dementia and dementia-free death of ARB versus ACEI initiation among US Veterans with incident hypertension. Methods: We conducted a ...

Association of Lacunes with Risk Factors, Cognition, and Atrophy: The Multi-Ethnic Study of Atherosclerosis (MESA)

Abstract Background: Lacunes are 3-15 mm cavities originating from small perforating artery disease and are a hallmark of cerebral small vessel diseas...

Cross-Domain Knowledge Transfer from Expert-Annotated Gated CT via Synthetic Ungated CT Improves Coronary Artery Calcium Scoring on CT Attenuation Correction Scans

Background: Coronary artery calcium (CAC) is an established measure of coronary atherosclerosis from computed tomography (CT). While deep learning (DL...

Combined triglyceride-glucose and frailty index (TyGFI) and risk of endometrial cancer in U.S. women aged >=45: NHANES 2011-2018 analysis integrating data engineering and machine learning with logistic modeling

Endometrial cancer (EC) incidence is closely linked to metabolic and hormonal factors. The TyGFI, a composite indicator integrating the triglyceride-g...

A foundation model of wearable pulse oximetry reveals physiological signatures of health and cardiometabolic risk

While Photoplethysmography (PPG) is established as a noninvasive optical tool for monitoring heart rate and oxygen saturation, its high-resolution blo...

Screening for Probable Undiagnosed Hypertension in US Adults Using Interpretable Machine Learning: An NHANES 2017-2018 Study

Background Hypertension remains one of the most challenging healthcare problems in the community. It is a common, measurable, and treatable condition ...

Cumulative Metabolic Exposure to Hyperglycemia and Risk of Cardiovascular and Limb Events in Peripheral Artery Disease

Background: Although diabetes is a potent risk factor for the development of peripheral artery disease (PAD), the effect of cumulative metabolic expos...

Evaluation of AI-Generated Synthetic Data for Clinical Research in Secondary Cardiovascular Prevention among Dyslipidemia Patients

BackgroundAccess to high-quality clinical data is essential for advancing medical research and developing effective medical statistical and Artificial...

POISE: Spectral Inference of Parent-of-Origin Effects in Unlabeled Genomic Data

Motivation: Parent of Origin Effects (POEs), where the effect of an an allele on a phenotype differs based on maternal or paternal inheritance implica...

Pre-AF 13: An Interpretable Atrial Fibrillation Risk Score Mined from Discharge Reports

Background. Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and a major determinant of prognosis. Established AF risk scores rely on...

Jun 9 2026 2606.10725v2
Sleep Temporal Entropy as a Digital Biomarker of Sleep Fragmentation for Cardiometabolic and Mortality Risk

Background Sleep fragmentation is increasingly recognized as a risk factor for cardiometabolic disease and mortality. However, existing measures prima...

Real-world safety profile of Enfortumab Vedotin: A comprehensive pharmacovigilance analysis based on the FDA Adverse Event Reporting System (FAERS)

Background: This study aimed to evaluate real-world adverse event (AE) signals of EV to provide evidence-based guidance for its safe clinical applicat...

Pre-AF 13: An Interpretable Atrial Fibrillation Risk Score Mined from Discharge Reports

Background. Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and a major determinant of prognosis. Established AF risk scores rely on...

Jun 9 2026 2606.10725v1
MetaPlate: Counterfactual-Guided RAG-LLM Tool for Personalized Food Recommendation and Hyperglycemia Prevention

Postprandial hyperglycemia is a key risk factor for metabolic disorders; however, existing dietary guidance is often static, impractical, and insuffic...

Jun 8 2026 2606.10120v1
Glycemic response trajectories on metformin monotherapy in real-world diabetes care

Objectives: Diabetes affects over 500 million people globally and glycemia is inadequately managed. Metformin is the most frequently prescribed initia...

Development and validation of a dynamic risk stratification tool for predicting multidrug-resistant bacterial infections in ICU patients: A clinical prediction model and web-based calculator

Background: Multi-drug resistant Bacterial (MDRB) Infections in the intensive care units (ICUs) substantially elevate patient mortality, prolong hospi...

MARVEL: Universal Murray's Law-informed Vessel Tree Segmentation and Topology Estimation

Vascular circulation follows fundamental biophysical principles that optimize mass transport and metabolic energy expenditure, which can be effectivel...

May 25 2026 2605.25363v1
Elevated serum apolipoprotein B and lipoprotein remodelling distinguish adults with HLH from HLH mimics and controls

Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterised by uncontrolled immune activation. Redu...

Exposome-Based Clustering of Urinary VOC and PAH Biomarkers Reveals Racially Patterned Cardiovascular Risk in a Nationally Representative US Cohort: A Machine Learning Analysis of NHANES 2017-2018

Background Polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) are combustion-derived pollutants linked to cardiovascular di...

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