Multiple Myeloma

Survival prediction and treatment optimization of multiple myeloma patients using machine-learning models based on clinical and gene expression data.

Multiple myeloma (MM) remains mostly an incurable disease with a heterogeneous clinical evolution. Despite the availability of several prognostic scores, substantial room for improvement still exists. Promising results have been obtained by integrating clinical and biochemical data with gene expression profiling (GEP). In this report, we applied machine learning algorithms to MM clinical and RNAse...

Dactyls and inward gripping stance for amphibious crab-like robots on sand.

Sandy beaches are areas that challenge robots of all sizes, especially smaller scale robots. Sand can hinder locomotion and waves apply hydrodynamic forces which can displace, reorient, or even invert the robot. Crab-like legs and gaits are well suited for this environment and could be used as inspiration for an improved design of robots operating in this terrain. Tapered, curved feet (similar to ...

Low Diagnostic Utility of Overnight High-Dose Dexamethasone Suppression Test in ACTH-Dependent Cushing's Syndrome.

OBJECTIVE: Overnight high-dose dexamethasone suppression test (ON-HDDST) is a simple test to localize the source of ACTH in patients with ACTH-depende...

Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects.

We present comboFM, a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cel...

Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of in mice model.

Diminazene diaceturate (DIM) and isometamidium chloride hydrochloride (ISMM) have been widely used for the treatment of animal trypanosomosis. We eval...

Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning.

There have been more than 2.2 million confirmed cases and over 120 000 deaths from the human coronavirus disease 2019 (COVID-19) pandemic, caused by t...

Physical and Chemical Stability of Dexamethasone Sodium Phosphate in Intravenous Admixtures Used to Prevent Chemotherapy-Induced Nausea and Vomiting.

Dilute intravenous (IV) admixtures of dexamethasone sodium phosphate (DSP) are becoming increasingly used in antiemetic regimens to prevent chemother...

Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii.

INTRODUCTION: The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the success...

Aeromonas hydrophila biofilm, exoprotease, and quorum sensing responses to co-cultivation with diverse foodborne pathogens and food spoilage bacteria on crab surfaces.

The effects of dual species interactions on biofilm formation by Aeromonas hydrophila in the presence of Pseudomonas aeruginosa, Pseudomonas fluoresce...

Effect of Cd and Pb Pollutions on Physiological Growth: Wavelet Neural Network (WNN) as a New Approach on Age Determination of Coenobita scaevola.

Environmental pollution of aquatic ecosystems leads to an interference in several fundamental biochemical and physiological functions. In this study t...

Development and validation of Lenalidomide in human plasma by LC-MS/MS.

A highly sensitive and ultra-fast high performance liquid chromatography- tandem mass spectrometry (LC-MS/MS) assay is developed and validated for the...

The Effect of Lenalidomide on Health-Related Quality of Life in Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes: Results From the MDS-005 Study.

BACKGROUND: The phase III MDS-005 study compared lenalidomide versus placebo in red blood cell transfusion-dependent (RBC-TD) patients with lower-risk...

Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration.

Combination antiemetic therapy has become common practice for the prevention of nausea and vomiting caused by anticancer drugs. In this study, we inve...

The Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglion.

 It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency o...

Randomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: a New York Cancer Consortium trial.

The proteasome inhibitor bortezomib enhances the effect of the selective estrogen receptor (ER) downregulator (SERD) fulvestrant by causing accumulati...

Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study.

INTRODUCTION: The present study evaluated the pharmacokinetics and safety of elotuzumab, a humanized IgG1 monoclonal antibody against signaling lympho...

Large Language Model Embeddings of Surgical Procedural Names for Confounding Adjustment in Perioperative Observational Studies

Background: Perioperative observational studies are increasingly used to evaluate anesthesia practices that are difficult to test in randomized trials...

Mapping the Transcriptional Landscape of Drug Responses in Primary Human Cells Using High-Throughput DRUG-seq

To advance our understanding of drug action in physiologically-relevant systems, we developed a high-throughput transcriptomic atlas of compound respo...

Transcript architecture predetermines m6A remodeling and sensory neuron vulnerability in chemotherapy-induced peripheral neuropathy

Whether individual transcripts carry intrinsic features that predetermine their response to external perturbations is unknown. Here we used nanopore d...

StructDiff: A Structure-Preserving and Spatially Controllable Diffusion Model for Single-Image Generation

This paper introduces StructDiff, a generative framework based on a single-scale diffusion model for single-image generation. Single-image generation ...