Nephrology

Latest AI and machine learning research in nephrology for healthcare professionals.

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Mechanistic study on comorbidities of kidney stones and sepsis using transcriptome sequencing combined with single-cell spatial transcriptome sequencing.

Kidney stones and sepsis have a complex pathological association. Urinary obstruction and infection caused by kidney stones can easily induce sepsis, leading to increased mortality and poor prognosis. However, the molecular mechanism underlying their comorbidity remains unclear, and there is a lack of specific biomarkers for early prediction and targeted therapy. This study aims to explore the mol...

Jul 17 2026 42469985

Machine learning models of depressive symptoms in middle-aged and elderly patients with chronic kidney disease: A cross-sectional study based on CHARLS.

This study aimed to develop and compare the performance of machine learning models in identifying depressive symptom status among middle-aged and elderly patients with chronic kidney disease (CKD), while identifying key factors that influence depressive symptoms. Data from the 2015 China Health and Retirement Longitudinal Study were used to construct the training and validation sets, while data fr...

Jul 17 2026 42469993
Construction and validation of a machine learning-based risk prediction model for venous thromboembolism in older adult patients: A multifactorial analysis of 28,231 cases.

Venous thromboembolism (VTE) is a leading preventable cause of in-hospital mortality in older adults, yet early risk stratification remains a key clin...

Jul 17 2026 42470007
Precision Medicine for Anticoagulation Strategies in the Cath Lab: Part 2.

PURPOSE OF REVIEW: Intraprocedural anticoagulation during percutaneous coronary intervention (PCI) remains particularly challenging in high-risk and u...

Jul 17 2026 42467330
Prospective Validation of Multi-week Inpatient Census Forecasting for Pediatric HSCT and Cellular Therapy.

BACKGROUND: Accurate inpatient census forecasting is important for cell therapy and blood and marrow transplantation (BMT) programs because bed capaci...

Jul 17 2026 42468827
An explainable real-time artificial intelligence -assisted system to reduce intradialytic hypotension.

BACKGROUND: Intradialytic hypotension (IDH) is a frequent complication in hemodialysis and is associated with adverse cardiovascular and neurological ...

Jul 17 2026 42469077
Clinical applications of artificial intelligence in hypertension management: current evidence and future perspectives.

BACKGROUND: Hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality worldwide, with persistently inadequate...

Jul 17 2026 42469487
Identification of lactate metabolism-related genes as kidney fibrosis biomarkers through integrated transcriptomic and experimental analyses.

Kidney fibrosis, the final pathological outcome of chronic kidney disease, lacks reliable biomarkers, and the role of lactylation in its pathogenesis ...

Jul 16 2026 42519023
Glycosylation-related gene risk model and functional validation of OSTC and TUBA1C in lung adenocarcinoma.

INTRODUCTION: OSTC and TUBA1C drive the malignant progression of lung adenocarcinoma (LUAD) through the modulation of N-glycosylation and the PI3K/AKT...

Jul 16 2026 42464299
Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets.

BACKGROUND: Diabetic kidney disease (DKD) is the primary global cause of end-stage renal disease. However, the aging-related gene networks driving its...

Jul 16 2026 42464365
A USP15/KRT17-associated 13-gene prognostic cluster and functional validation in EGFR-mutant lung adenocarcinoma.

BACKGROUND: EGFR-mutant lung adenocarcinoma (LUAD) exhibits significant prognostic heterogeneity despite the efficacy of tyrosine kinase inhibitors. T...

Jul 16 2026 42458519
Medical student reliance on artificial intelligence in nephrology education.

BACKGROUND: Large language models such as ChatGPT are increasingly used in medical education and may influence student learning and decision-making. D...

Jul 16 2026 42460549
Unlocking the Chemical Space for Rechargeable Batteries with a Generative Solvent Design System.

Electrolyte discovery for rechargeable batteries today relies on heuristic trial-and-error or high-throughput screening of existing molecules. Here, w...

Jul 16 2026 42460978
Development and internal validation of an interpretable machine learning model using routine laboratory data for systemic sclerosis-associated pulmonary arterial hypertension.

This study aimed to develop and validate an interpretable machine learning (ML) model using routine laboratory data to support clinical decision-makin...

Jul 16 2026 42461382
Using Artificial Intelligence to Identify Patterns and Predictors of Adverse Drug Reactions in Cardiovascular Patients: A Comprehensive Narrative Review.

Artificial intelligence (AI) has emerged as a transformative tool for improving the detection, prediction, and prevention of adverse drug reactions (A...

Jul 16 2026 42461503
Machine Learning Analysis of Sex Differences in Cardiovascular-Kidney-Metabolic Risk Factors and Prognosis Among Patients With Moderate-to-Severe Coronary Artery Calcification: Prospective Cohort Study.

BACKGROUND: Patients with coronary artery calcification exhibit notable sex differences in clinical presentation, particularly concerning the role of ...

Jul 16 2026 42462211
Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.

The therapeutic landscape of colorectal cancer (CRC) has evolved with the identification of molecular subtypes, including mismatch repair-deficient/mi...

Jul 16 2026 42462280
Personalised approach to hypertension treatment: protocol for the HYPERMARKER randomised controlled trial.

INTRODUCTION: Blood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent on clinician ...

Jul 16 2026 42463190
Prognostic survival models for diffuse large B-cell lymphoma using statistical and machine learning approaches.

Although diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, existing prognostic tools, including the revised International Prognostic I...

Jul 16 2026 42463804
Acute kidney injury severity in ICU patients: Developing and evaluating a data-driven analysis of clinical covariates using machine learning.

BACKGROUND: Acute kidney injury remains a major cause of morbidity and mortality in critically ill patients. Existing classification systems rely on s...

Jul 16 2026 42461941
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