Nephrology

Latest AI and machine learning research in nephrology for healthcare professionals.

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Machine learning–driven decoding of maternal immune signatures in repeated pregnancy loss

Repeated pregnancy loss (RPL) is a multifactorial condition in which the underlying immunological me...

Non-Invasive Diagnostic Evaluation of Urinary Exosomal Let-7c Cluster Expression in Bladder Cancer Using Machine Learning Approaches

Bladder cancer (BCa) diagnosis typically relies on invasive cystoscopy, which is effective but costl...

Multi-omics Integration of Microbiota Transplant Therapy in Children with Autism Spectrum Disorders

Microbiota transplant therapy (MTT) is a promising avenue for the substantial improvement of gastroi...

Bioimage analysis for multiplexed FUCCI acquisitions powered by deep learning

The FUCCI sensor fluorescently labels cell cycle phases, which is essential to assess normal and abn...

The Liver is an Inflammatory Mediator of Pulmonary Arterial Hypertension

Inflammation is central to pulmonary arterial hypertension (PAH) pathogenesis. The liver regulates s...

Cancer target discovery enabled by transcriptome-based virtual CRISPR screening

Functional genetic screens have uncovered dependencies in many cancers, but experimentally screened ...

Nephrobase Cell+: Multimodal Single-Cell Foundation Model for Decoding Kidney Biology

Large foundation models have revolutionized single-cell analysis, yet no kidney-specific model curre...

A comprehensive functional landscape of α-tubulin TUBA1A variants illuminates microtubule biology and refines clinical classification

Missense variant interpretation in highly conserved, paralog-rich gene families remains a critical b...

Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems

Preclinical models are used extensively to study diseases and potential therapeutic treatments. Comp...

Kidney Tissue Characterization using Normalized Raman Imaging and Segment-Anything

Normalized Raman Imaging (NoRI) enables high-resolution, label-free quantification of protein and li...

Normalized Raman Imaging for Studies of Tissue Physiology of the Kidney

Histology is the cornerstone of clinical pathology and an essential tool for many areas of medicine....

Deep Learning Enables Automated Segmentation and Quantification of Ultrastructure from Transmission Electron Microscopy Images

The widths of kidney glomerular basement membrane (GBM) and podocyte foot processes (FP) are essenti...

SAM-based Automatic Workflow for Histology Cyst Segmentation in Autosomal Dominant Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized by the deve...

Lab-in-the-loop therapeutic antibody design with deep learning

Therapeutic antibody design is a complex multi-property optimization problem with substantial promis...

GlomExtractor: a versatile tool for extracting glomerular patches from whole slide kidney biopsy images

The extraction of glomerular image patches is a key step prior to the training and application of gl...

Automated spermatogenic staging in PAS-stained testes of Sprague-Dawley rats using a deep learning model for normal and atrophied tissues

The spermatogenic stage serves as a vital criterion for assessing normal spermatogenesis and is cent...

The Macroevolution of Filamentation Morphology Across the Saccharomycotina Yeast Subphylum

Saccharomycotina yeasts are a highly diverse and widely distributed subphylum of ascomycete fungi th...

Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection

Long-term transplant success is limited by allograft rejection, a complex process traditionally stud...

Evolutionarily Conserved T-tubule-Mitochondria Contacts in Striated Muscle

The intricate architecture of skeletal muscle is essential for its contractile function, with the sp...

Hierarchical Machine Learning Uncovers Topological Signatures of Autophagy Regulation by Oral Bacteria in Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) progression has been increasingly linked to dysbiosis of the ora...

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