Nephrology

Development and validation of a machine learning model for individualised meropenem dosing in CRRT patients.

Optimizing meropenem dosing in critically ill patients undergoing continuous renal replacement thera...

Percutaneous nephrostomy guidance by a convolutional-neural-network-based optical coherence tomography endoscope.

Percutaneous nephrostomy is widely used in kidney access surgeries. Despite its prevalence in urolog...

Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

BACKGROUND: Vancomycin-resistant Enterococcus (VRE) infection is a life-threatening complication aft...

PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes.

BACKGROUND AND AIMS: Pulmonary arterial hypertension (PAH) is a severe disease with limited effectiv...

Integrated analysis of therapeutic strategies and prognostic factors in advanced lung adenocarcinoma: Retrospective study with emphasis on gene assays, multimodality treatment approaches and predictive machine learning models.

Patients with advanced lung adenocarcinoma have a range of treatment options, including targeted the...

Heterogeneous associations of a mobile health-based disease management program on uncontrolled hypertension: A target trial emulation study.

Long-term effectiveness of digital health interventions for hypertension remains unclear, particular...

Harnessing the gut-heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategies.

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide despite major advances...

Systemic Proteome Profiling to Differentiate Primary Glomerular Diseases.

BACKGROUND: Primary glomerulonephritis (GN) is a heterogeneous group of kidney disorders where under...

A Hybrid Physics-Driven Neural Network Force Field for Liquid Electrolytes.

Electrolyte design plays an important role in the development of lithium-ion batteries and sodium-io...

Machine Learning-Based Preoperative Predicting TERT Promoter Mutation and EGFR Gene Amplification Phenotype in IDH Wild-Type Glioblastoma Using Advanced MR Habitat Imaging.

BACKGROUND AND PURPOSE: The telomerase reverse transcriptase (TERT) gene promoter mutation is a cruc...

Association between visceral adipose tissue measured by deep neural network architecture and chronic kidney disease.

The relationship between abdominal body composition and chronic kidney disease (CKD) is well-documen...

Bridging structure and function: artificial intelligence-based modelling of kidney proteins.

The ability to predict the three-dimensional structure of a protein from its amino acid sequence has...

Multimodal MRI-based two-stage artificial intelligence framework for renal fibrosis classification in chronic kidney disease.

Association between fundus sex index and hypertension, diabetes mellitus, and smoking in the Kumejima study.

Fundus parameters can be used to quantify masculinity or femininity as a fundus sex index (FSI) rang...

MAAR-Net: Multi-scale attention-assisted residual neural network for renal microvascular structure segmentation.

Renal disease represents a significant public health concern, with renal microvascular lesions playi...

Neoadjuvant Systemic Therapy in Kidney and Bladder Cancer: Current Evidence and Emerging Paradigms.

Neoadjuvant systemic therapy has emerged as a strategy to improve outcomes in high-risk localized ge...

Phenoxy-linked colchicine derivatives: A structure-based approach toward enhanced selectivity and α-tubulin interaction.

Colchicine, a well-known microtubule assembly inhibitor that binds to β-tubulin, has limited clinica...

Natural language processing of biomedical text to map and prioritize protein-disease associations in HFpEF.

The validation of promising clinical biomarkers, molecular mechanisms, and novel drug targets in car...

An optimized machine learning model based on hematological indicators for the noninvasive identification of baicalin's therapeutic effects in pulmonary hypertension.

Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder with high mortality, necessita...

Characterization of Kidney and Liver Cystic Phenotype Associated with GANAB Using Advanced Imaging Biomarkers.

UNLABELLED: : Background and Hypothesis: Monoallelic pathogenic variants in GANAB cause autosomal do...

Influence of body composition on the efficacy of nivolumab plus ipilimumab for metastatic clear cell renal cell carcinoma.

BACKGROUND: Immune checkpoint inhibitor therapy (ICI) with nivolumab+ipilimumab is a first-line (1L)...