Latest AI and machine learning research in nephrology for healthcare professionals.
Large foundation models have revolutionized single-cell analysis, yet no kidney-specific model currently exists, and it remains unclear whether organ-focused models can outperform generalized models. The kidney’s complex cellular architecture and dynamic microenvironments further complicate integration of large-scale single-cell and spatial omics data, where current frameworks trained on limited d...
Missense variant interpretation in highly conserved, paralog-rich gene families remains a critical bottleneck for precision medicine. Here, we developed an integrated experimental-computational platform to systematically assess the functional impact of all possible missense mutations in the α-tubulin TUBA1A. Combining high-throughput comprehensive mutagenesis, high-content imaging, convolutional n...
Preclinical models are used extensively to study diseases and potential therapeutic treatments. Complex in vitro platforms incorporating human cellula...
Normalized Raman Imaging (NoRI) enables high-resolution, label-free quantification of protein and lipid concentrations in biological tissues. Because ...
Histology is the cornerstone of clinical pathology and an essential tool for many areas of medicine. Nevertheless, conventional histological methods, ...
The widths of kidney glomerular basement membrane (GBM) and podocyte foot processes (FP) are essential ultrastructural markers for assessing kidney fu...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized by the development of numerous cysts in the kidneys, ultimate...
Therapeutic antibody design is a complex multi-property optimization problem with substantial promise for improvement with the application of machine-...
The extraction of glomerular image patches is a key step prior to the training and application of glomerular classification models. Numerous algorithm...
The spermatogenic stage serves as a vital criterion for assessing normal spermatogenesis and is central to evaluating reproductive toxicity. Current m...
Saccharomycotina yeasts are a highly diverse and widely distributed subphylum of ascomycete fungi that exhibit diversity in their asexual growth morph...
Long-term transplant success is limited by allograft rejection, a complex process traditionally studied on an organ-specific basis. To establish a uni...
The intricate architecture of skeletal muscle is essential for its contractile function, with the spatial organization of organelles such as T-tubules...
Oral squamous cell carcinoma (OSCC) progression has been increasingly linked to dysbiosis of the oral microbiome. We hypothesized that pathogenic vers...
Endometriosis affects ∼10% of reproductive-age women, yet targeted non-hormonal therapies remain unavailable, and treatment response is highly variabl...
The non-small cell lung cancer (NSCLC)-associated Epidermal Growth Factor Receptor (EGFR) mutant L858R/T790M confers resistance to first- and second-g...
Hypertension is a major risk factor for cardiovascular diseases, with changes in gut microbiota composition and function being closely associated with...
EGFR amplification occurs in approximately 40-50% of glioblastoma (GBM) cases and is critical for treatment selection [1]. However, GBM tissue samples...
The BCL-XL anti-apoptotic protein is a clear cell Renal Cell Carcinoma (ccRCC) dependency; however, the mechanism of this dependence and its relevance...
Biological neural networks contain diverse cell types with heterogeneous electrophysiological properties. Artificial neural networks (ANNs) model comp...