Nephrology

Subtype-Specific Dependencies and Drug Vulnerabilities Enable Precision Therapeutics in Head and Neck Cancer

Molecular heterogeneity in head and neck squamous cell carcinoma (HNSCC) is well recognized, yet existing subtype frameworks remain largely descriptive and have not translated into therapeutic decision-making. Here, we establish a mechanistic platform that converts transcriptomic diversity into drug-actionable tumor states. Integrating multi-cohort RNA-seq from 727 tumors across five independent d...

Morphometry-based detection of deep learning faults in glomerular segmentation

Deep learning-based segmentation has evolved to a powerful strategy for automatically annotating glomeruli in kidney biopsy images. However, since any artificial intelligence can make mistakes, strategies for identifying and correcting faulty annotations are often indispensable. Yet, how can such a validation be achieved without the laborious task of a pathologist manually checking every single im...

ORAKLE: Optimal Risk prediction for mAke30 in patients with acute Kidney injury using deep Learning

Major Adverse Kidney Events within 30 days (MAKE30) is an important patient-centered outcome for assessing the impact of acute kidney injury (AKI). Th...

Predicting Hypertension Among HIV Patients on Antiretroviral Therapy in Rural Eastern Cape, South Africa Using Machine Learning

Hypertension continues to be a major challenge in developing countries like South Africa, as it significantly contributes to the cardiovascular diseas...

Impact of Mydriasis on Image Gradability and Automated Diabetic Retinopathy Screening with a Handheld Camera in Real-World Settings

Diabetic retinopathy (DR) screening in low- and middle-income countries (LMICs) faces challenges due to limited access to specialized care. Portable r...

Development and Validation of Machine Learning Models for Adverse Events after Cardiac Surgery

Early recognition of adverse events after cardiac surgery is vital for treatment. However, the widely used Society of Thoracic Surgery (STS) risk mode...

A Multimodal Sleep Foundation Model Developed with 500K Hours of Sleep Recordings for Disease Predictions

Sleep is a fundamental biological process with profound implications for physical and mental health, yet our understanding of its complex patterns and...

Integration of CA attention and KAN algorithm to predict EGFR mutation status in lung cancer

Epidermal Growth Factor Receptor (EGFR) mutations are critical biomarkers for targeted therapies in non-small cell lung cancer (NSCLC). However, conve...

Development and validation of a multivariable Prediction Model for Pre-diabetes and Diabetes using Easily Obtainable Clinical Data

In the US, pre-diabetes and diabetes are increasing in prevalence alongside other chronic diseases. Hemoglobin A1c is the most common diagnostic test ...

XGBoost-Based Prediction of ICU Mortality in Sepsis-Associated Acute Kidney Injury Patients Using MIMIC-IV Database with Validation from eICU Database

Sepsis-Associated Acute Kidney Injury (SA-AKI) leads to high mortality in intensive care. This study develops machine learning models using the Medica...

Predicting mortality in critically ill patients with hypertension using machine learning and deep learning models

Accurate prediction of mortality in critically ill patients with hypertension admitted to the Intensive Care Unit (ICU) is essential for guiding clini...

Machine Learning Based Classification of Aggressive and Malignant Renal Tumors from Multimodal Data

This study aimed to develop and evaluate a machine learning pipeline using multiphase contrast-enhanced CT images and clinical data to classify renal ...

Unbiased multi-omics network-based data integration allows clinically relevant outcome-predicting clustering of individuals with heart failure

Heart failure is a multifaceted clinical syndrome, in which the heart fails to supply adequate blood to meet the body’s oxygen and nutrients needs. Ev...

Development and Application of Natural Language Processing on Unstructured Data in Hypertension: A Scoping Review

Hypertension is a global health concern with a vast body of unstructured data, such as clinical notes, diagnosis reports, and discharge summaries, tha...

Development of an artificial intelligence-generated, explainable treatment recommendation system for urothelial carcinoma and renal cell carcinoma to support multidisciplinary cancer conferences

Decisions on the best available treatment in clinical oncology are based on expert opinions in multidisciplinary cancer conferences (MCC). Artificial ...

RNAseq-Based Machine Learning Models for Prognostication of Multiple Myeloma

Multiple myeloma (MM) is characterized by abnormal plasma cell proliferation in the bone marrow, leading to symptoms like osteolytic lesions, anemia, ...

InfEHR: Resolving Clinical Uncertainty through Deep Geometric Learning on Electronic Health Records

Electronic health records (EHRs) contain multimodal data that can inform diagnostic and prognostic clinical decisions but are often unsuited for advan...

Deep generative models for vessel segmentation in CT angiography of the brain

Automated vessel segmentation in brain CT angiography (CTA) remains challenging despite the potential benefit of applications. Expert acquisition of r...

MRI-Derived Variables Combined with Machine Learning for Pulmonary Hypertension Risk Prediction: A Retrospective Analysis

Pulmonary hypertension (PH) is a severe and progressive vascular disease for which early diagnosis and risk stratification are critical for improving ...

Impact of Iron Deficiency on Clinical Outcomes in Congestive Heart Failure: A Retrospective Analysis of Risk Stratification and Mortality

Iron deficiency frequently coexists with congestive heart failure, thereby increasing morbidity and mortality. Although guidelines typically define ir...