Nephrology

Latest AI and machine learning research in nephrology for healthcare professionals.

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Heat and hearts: An exposure-anchored computational phenotyping framework for assessing cardiovascular vulnerability during extreme heat.

OBJECTIVE: Extreme heat is associated with increased cardiovascular vulnerability. We developed and validated a heat exposure-anchored cardiovascular vulnerability (HECV) computational phenotype for outpatient visits using longitudinal EHR data linked to high-resolution temperature. MATERIALS AND METHODS: We assembled a loyalty cohort of adult patients from a large Chicago-based health system (201...

Mar 22 2026 41875960

Can ensemble methods improve predictive performance of existing models estimating chronic kidney disease among patients with diabetes?

BACKGROUND: Clinical prediction models often suffer from poor model transportability and/or subgroup performance resulting from using a single data source. We aimed to determine whether ensemble methods can combine multiple existing models to improve predictive performance when compared to component models. METHODS: As a case study, we used electronic medical records from the Canadian Primary Care...

Mar 21 2026 41895024
From algorithms to action: Risk stratification for arteriovenous fistula failure in hemodialysis.

BACKGROUND: Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis, yet primary failure and early dysfunction remain common, th...

Mar 21 2026 41863397
Regulation of calcium homeostasis by S100A12 drives NETosis in chronic kidney disease.

Chronic kidney disease (CKD) is characterized by persistent renal injury and inflammation. Although S100A12 is associated with inflammatory states, it...

Mar 21 2026 41862672
Rapid quantitative urinary chloride sensing with conductivity correction for cardiac patient management.

We present a rapid, accurate and miniaturized electrochemical platform for urinary chloride measurement using chronopotentiometry coupled with conduct...

Mar 20 2026 41886973
Artificial intelligence models for osteoporosis risk prediction in postmenopausal women with CKD: A cross-sectional analysis of NHANES 2005 to 2018.

Artificial intelligence (AI) can transform osteoporosis (OP) screening, but its application in high-risk, complex populations like postmenopausal wome...

Mar 20 2026 41861191
Machine learning approaches to predict 24-hour urine collection results based on self-reported beverage intake.

OBJECTIVE: Repeated 24-hour urine collections are used to evaluate risk factors for recurrence of kidney stones but are costly and burdensome. This st...

Mar 19 2026 41864591
Integrated machine learning and multi-omics analysis identifies ALOX5 as a potential therapeutic target for tubulointerstitial inflammation in diabetic kidney disease.

Diabetic kidney disease (DKD) is a leading cause of renal failure. Inflammation of the renal tubules and interstitium is a critical factor in the prog...

Mar 19 2026 41857149
Exploration of network-based, machine learning, MD simulations, and MM/GBSA approaches revealed luteolin from Gynura procumbens as key inhibitor of MMP9 in NSCLC.

The primary leading reason for cancer death is non-small-cell lung cancer (NSCLC) still up to date globally. Even with today's advanced technology, it...

Mar 19 2026 41854859
The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHANES and CHARLS.

BACKGROUND: Sarcopenia has been proved to be associated with cardiovascular diseases, chronic kidney disease, and metabolic disorders, but the relatio...

Mar 19 2026 41855358
Breaking the Air-Water Paradigm: Ion Behavior at Hydrophobic Solid-Water Interfaces.

Hydrophobic solid-water interfaces underpin processes in nanofluidics, electrochemistry, and energy technologies. Microscopic insights into these syst...

Mar 19 2026 41855396
Machine Learning-Based Risk Prediction for Coronary Heart Disease Complicated by Hyperhomocysteinemia: Retrospective Study.

BACKGROUND: Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for coronary heart disease (CHD), yet accurately predicting CHD ri...

Mar 19 2026 41855468
Development and Validation of a Machine Learning Model for Predicting 3-Year Overall Survival After Transjugular Intrahepatic Portosystemic Shunt: A Retrospective Multicenter Study.

BACKGROUND AND AIMS: Predicting overall survival (OS) in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) remains ch...

Mar 19 2026 41848728
Deep Learning Echocardiographic Trajectories of Heart Failure With Preserved Ejection Fraction: A Retrospective Cohort Study.

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a dynamic chronic disease. Specific disease trajectories remain unclear. OBJECTI...

Mar 18 2026 41855744
Development and Validation of a Machine Learning Model for Incident Heart Failure Prediction in Chronic Kidney Disease: A Multicenter Cohort Study.

BACKGROUND: Chronic kidney disease (CKD) and heart failure (HF) share pathophysiological mechanisms, rendering HF one of the most burdensome cardiovas...

Mar 18 2026 41848060
A Scoping Review of Machine Learning Applications for Diagnosis, Classification, and Prognosis in Lupus Nephritis.

BACKGROUND: Over the past decade, machine learning (ML) has transformed histopathology, yet its application in lupus nephritis (LN) remains underexplo...

Mar 18 2026 41848794
Developing a practical machine learning model to predict post implantation syndrome after endovascular aneurysm repair.

BACKGROUND: Post-implantation syndrome (PIS) is recognized as a systemic inflammatory response following endovascular aneurysm repair (EVAR), characte...

Mar 18 2026 41848989
Development and validation of an artificial intelligence-based model for predicting teicoplanin plasma concentrations in intensive care unit patients with pulmonary infections: a retrospective study.

INTRODUCTION: Teicoplanin is widely used to treat pulmonary infections, particularly in critically ill patients with gram-positive bacterial infection...

Mar 18 2026 41849094
The Burden, Outcomes, and Management of Patients with Aldosterone Dysregulation: A Targeted Literature Review.

INTRODUCTION: Aldosterone dysregulation (excess aldosterone production at the source within the adrenal glands) in the absence of primary aldosteronis...

Mar 18 2026 41849107
Detection of Non-diabetic Kidney Disease in Patients with Diabetes Using Machine Learning and Electronic Medical Record Data.

INTRODUCTION: The identification of non-diabetic kidney disease (NDKD) in diabetic patients is critically important. Unlike diabetic nephropathy, NDKD...

Mar 18 2026 41849636
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