Nephrology

Coixol Protects Against Acute Kidney Injury by Reducing Cell Senescence.

Acute kidney injury (AKI) is associated with increased in-hospital mortality, yet effective therapeu...

Fibrogenesis-driven tumor progression in clear cell renal cell carcinoma: prognostic, therapeutic implications and the dual role of neuropilin-1.

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the predominant subtype of renal cancer, with...

Identification of Key Genes and Potential Therapeutic Targets in Sepsis-Associated Acute Kidney Injury Using Transformer and Machine Learning Approaches.

Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening complication of sepsis, charact...

Dynamic Predictive Models of Cardiogenic Shock in STEMI: Focus on Interventional and Critical Care Phases.

: While early risk stratification in STEMI is essential, the threat of cardiogenic shock (CS) persis...

Prediction of Poor Visual Outcomes at Idiopathic Intracranial Hypertension Diagnosis Using a Supervised Machine Learning Algorithm.

BACKGROUND: Idiopathic intracranial hypertension (IIH) is a vision-threatening disorder mainly affec...

Patient Voices in Dialysis Care: Sentiment Analysis and Topic Modeling Study of Social Media Discourse.

BACKGROUND: Patients with end-stage kidney disease undergoing dialysis face significant physical, ps...

Deciphering the Immunomodulatory Function of GSN Inflammatory Cancer-Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan-Cancer Single-Cell Landscape and Spatial Transcriptomics Analysis.

The heterogeneity of cancer-associated fibroblasts (CAFs) could affect the response to immune checkp...

External Validation of a CT-Based Radiogenomics Model for the Detection of EGFR Mutation in NSCLC and the Impact of Prevalence in Model Building by Using Synthetic Minority Over Sampling (SMOTE): Lessons Learned.

RATIONALE AND OBJECTIVES: Radiogenomics holds promise in identifying molecular alterations in nonsma...

Exosomes derived from human umbilical cord mesenchymal stem cells attenuate senescence of peritoneal mesothelial cells by inhibiting oxidative stress.

OBJECTIVE: Aging is a natural process that affects cellular function. In peritoneal dialysis (PD), c...

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib.

Fruquintinib (FRUZAQLA) is a highly selective tyrosine kinase inhibitor of all three vascular endoth...

Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin-Independent Regulation of Fpn mRNA.

The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) ...

Push Forward Clinical Management of Hematological Toxicity due to Lenalidomide Overexposure: Model-Informed Precision Dosing for Chinese Population With Renal Insufficiency.

Dose-dependent hematological toxicity of lenalidomide has been reported previously, and thus, there ...

Semi-quantitative analysis of Right Ventricular Myocardial First-pass Perfusion Using Cardiac Magnetic Resonance Imaging in Systemic Sclerosis and Pulmonary Arterial Hypertension.

BACKGROUND: Right ventricular (RV) myocardial perfusion has been touted as a primary mechanism to un...

Inadequate imipenem dosing in patients with decreased kidney function: A clinical pharmacokinetic study.

OBJECTIVES: A number of population pharmacokinetic (popPK) models of imipenem in critically ill pati...

Enhancing clinical decision-making in closed pelvic fractures with machine learning models.

Closed pelvic fractures can lead to severe complications, including hemodynamic instability (HI) and...

55 MHz constant field dielectric warming of kidneys and ovaries cryopreserved by vitrification.

Organs cryopreserved by vitrification benefit from fast warming to avoid growth and recrystallizatio...

Comparison of Machine Learning Algorithms and Bayesian Estimation in Predicting Tacrolimus Concentration in Tunisian Kidney Transplant Patients During the Early Post-Transplant Period.

BACKGROUND AND OBJECTIVE: Model-informed precision dosing (MIPD), based on a Bayesian approach and m...

AI-driven glomerular morphology quantification: a novel pipeline for assessing basement membrane thickness and podocyte foot process effacement in kidney diseases.

BACKGROUND AND OBJECTIVE: Measuring the thickness of the glomerular basement membrane (GBM) and asse...

Artificial Intelligence: The New Transplant Selection Committee Member.

Enhancing Organ Allocation Efficiency: A Pilot Study Evaluating Artificial Intelligence-Assisted Assessment of Donor Kidney Pathology.

PURPOSE: The purpose of this study is to evaluate the effectiveness of an artificial intelligence (A...

Active Organic Salts Enabling Non-Intrusive Electrolyte Presodiation Strategy.

Na-ion batteries show great promise, but their practical utilization is hindered by irreversible Na-...