Latest AI and machine learning research in neurology for healthcare professionals.
Isolated rapid eye movement (REM) sleep behaviour disorder (RBD) is an early stage of alpha-synucleinopathies, such as Parkinson's disease (PD). Actigraphy is a promising tool for assessing rest-activity patterns, however its diagnostic or predictive value in these disorders is understudied. This study evaluated AI-based models applied to actigraphy data to improve the detection of PD and RBD, add...
Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder worldwide, with projections exceeding 25 million people by 2050. Its burden, however, is unevenly distributed. Many low- and middle-income countries face rapidly rising prevalence alongside profound shortages in neurological workforce, infrastructure, and access to specialised care and essential therapies. This global "Park...
Endovascular thrombectomy (EVT) has transformed the treatment of acute ischemic stroke (AIS). However, a substantial proportion of AIS patients experi...
The monoamine oxidase B (MAO-B) enzyme and Sigma-1 (Sig-1R) receptor are therapeutically relevant targets implicated in neurodegenerative and neuropsy...
BACKGROUND: Asynchronous online forums provide flexible, accessible peer support for many people living with dementia and carers. Moderators are centr...
PURPOSE: To test the hypothesis that T1-w and T2-w volumetric pipelines are not interchangeable, particularly regarding their differential sensitivity...
Atrazine (ATR) is a globally prevalent herbicide linked to increased risks of cognitive impairment and neurodegeneration, but its molecular mechanism ...
Clinical trial design (CTD) is a time-consuming process that requires substantial domain expertise. Large-scale real-world data (RWD), such as electro...
BACKGROUND: Multiple sclerosis (MS) is a chronic neurological disease affecting both white and gray matter of the central nervous system. Despite the ...
Cell types represent groups of cells with shared anatomical and functional properties. Traditional brain cell type atlases rely on single-cell sequenc...
BACKGROUND: Artificial intelligence is an increasingly valuable tool in ischemic stroke management. This systematic review and meta-analysis evaluated...
BACKGROUND: Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas often arising in the spine, characterized by high metastatic pot...
BACKGROUND: Surgical treatment for spinal metastases is associated with high perioperative risk due to tumor burden, neurologic compromise, and limite...
Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), essential tremor (ET), multiple sclerosis (MS), and Parkinson's disease (PD) are c...
BACKGROUND: Intraoperative neuromonitoring (IONM) reduces postoperative neurological complications, but its precise value for neurological outcomes re...
OBJECTIVE: This review systematically evaluates the current research landscape, methodological characteristics, and translational challenges of artifi...
BACKGROUND: Brain volumetry software is widely accepted for assessment in Alzheimer's disease. However, direct comparisons for software-specific predi...
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving a complex interplay of interconnected pharmacological targets, a fea...
INTRODUCTION: Histone deacetylase 6 (HDAC6) is a unique class IIb enzyme characterized by dual catalytic domains and predominant cytoplasmic localizat...
INTRODUCTION: Ischemic stroke remains a leading cause of death in the United States, with the COVID-19 pandemic exacerbating disparities. Prior studie...