Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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Heterogeneous Treatment Effect for Targeted Temperature Management After Cardiac Arrest: A Causal Machine Learning Analysis

ABSTRACT Objectives: To determine whether heterogeneous treatment effects (HTE) explain the inconclusive results of targeted temperature management (TTM) trials after cardiac arrest, using causal machine learning across four datasets. Design: Secondary analysis of one multicenter RCT and three observational ICU cohorts using S-learner and forest-based R-learner models to estimate conditional avera...

Can Multimodal Large Language Models Understand Pathologic Movements? A Pilot Study on Seizure Semiology

Multimodal Large Language Models (MLLMs) have demonstrated robust capabilities in recognizing everyday human activities, yet their potential for analyzing clinically significant involuntary movements in neurological disorders remains largely unexplored. This pilot study evaluates the capability of MLLMs for automated recognition of pathological movements in seizure videos. We assessed the zero-sho...

May 5 2026 2605.03352v1
Psychedelics Align Brain Activity with Context

Psychedelics can profoundly alter consciousness by reorganising brain connectivity; however, their effects are context-sensitive. To understand how th...

Joint Variable Selection for Omic Biomarkers in Time-to-Event Data

The incidence of the vast majority of neurodegenerative, cancer, and metabolic diseases generally increases exponentially with age. In large-scale bio...

SIMON: Saliency-aware Integrative Multi-view Object-centric Neural Decoding

Recent EEG-to-image retrieval methods leverage pretrained vision encoders and foveation-inspired priors, but typically assume a fixed, center-focused ...

May 1 2026 2605.00401v1
Prediction of Alzheimer's Disease Risk Factors from Retinal Images via Deep Learning: Development and Validation of Biologically Relevant Morphological Associations in the UK Biobank

The systemic, metabolic, lifestyle factors have established associations with Alzheimer's Disease (AD) through epidemiologic and AD-specific biomarker...

May 1 2026 2605.00665v1
A biologically annotated neural network for proteomic discovery in Parkinsons disease

Machine learning models that can utilize high-dimensional data to make predictions and derive biological insights can improve understanding of disease...

NEURA: An agentic system for autonomous neuroimaging workflows

Neuroimaging is essential for studying the human brain; however, the deep interdisciplinary expertise required imposes a very high threshold, limiting...

DrugPTM-Bench: A Large-Scale Dataset for Predictive Modeling of Drug-Induced Cell Type-Specific Protein Post-Translational Modifications

Protein post-translational modifications (PTMs), particularly phosphorylation, serve as the primary molecular switches that orchestrate cellular signa...

BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learning

Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substa...

Apr 30 2026 2604.27277v1
AG-TAL: Anatomically-Guided Topology-Aware Loss for Multiclass Segmentation of the Circle of Willis Using Large-Scale Multi-Center Datasets

Accurate multiclass segmentation of the Circle of Willis (CoW) is essential for neurovascular disease management but remains challenging due to comple...

Apr 30 2026 2604.27357v1
Cross-Subject Generalization for EEG Decoding: A Survey of Deep Learning Methods

Deep learning for cross-subject EEG decoding is hindered by high inter-subject variability, which introduces a severe domain shift between training an...

Apr 29 2026 2604.27033v1
An Interpretable Deep Learning Framework Reveals Frontoparietal Control Network Hyperactivation Underlying Autism Diagnosis and Symptom Severity

BACKGROUND: Autism spectrum disorder (ASD) is marked by profound neurobiological heterogeneity, which drives inconsistent neuroimaging findings and im...

Artificial Intelligence, LLM-based generation of synthetic patients with Parkinson's Disease: towards a digital twin paradigm for in silico studies

Heterogeneity in sporadic Parkinson's Disease (PD) is a critical problem that drives variable rates of progression and treatment response and complica...

Yawning reveals energy-dynamics mismatch and neural inertia across state transitions

Yawning is a highly conserved behavior, yet its neural dynamics across arousal state transitions remain poorly understood. Classical reflex models fai...

ViBE: Visual-to-M/EEG Brain Encoding via Spatio-Temporal VAE and Distribution-Aligned Projection

Brain encoding models not only serve to decipher how visual stimuli are transformed into neural responses, but also represent a critical step toward v...

Apr 29 2026 2604.26218v1
Virtual-reality based patient-specific simulation of spine surgical procedures: A fast, highly automated and high-fidelity system for surgical education and planning

Surgical training involves didactic teaching, mentor-led learning, surgical skills laboratories, and direct exposure to surgery; however, increasing c...

Apr 29 2026 2604.26781v1
A Data-Centric Framework for Intraoperative Fluorescence Lifetime Imaging for Glioma Surgical Guidance

Accurate intraoperative assessment of glioma infiltration is essential for maximizing tumor resection while preserving functional brain tissue. Fluore...

Apr 28 2026 2604.26147v1
Real-time prospective (shadow mode) validation of an AI-based clinical decision support system for predicting 3-month functional outcome in acute stroke: the VALIDATE study protocol

Introduction Despite the proven benefits of reperfusion therapies in acute ischemic stroke, treatment decisions in the hyperacute phase remain complex...

BETA: Resting-state fMRI Biotypes for tDCS Efficacy in Anxiety Among Older Adults At Risk For Alzheimer's Disease

Anxiety is usually gauged by self-report, yet a single symptom level can reflect disparate neural circuitry. In Alzheimer's disease and related dement...

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