Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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Attention-Based Deep Learning for Early Parkinson's Disease Detection with Tabular Biomedical Data

Early and accurate detection of Parkinson's disease (PD) remains a critical challenge in medical diagnostics due to the subtlety of early-stage symptoms and the complex, non-linear relationships inherent in biomedical data. Traditional machine learning (ML) models, though widely applied to PD detection, often rely on extensive feature engineering and struggle to capture complex feature interaction...

Feb 8 2026 2602.07933v1

Multimodal normative modeling in Alzheimers Disease with introspective variational autoencoders

Normative modeling learns a healthy reference distribution and quantifies subject-specific deviations to capture heterogeneous disease effects. In Alzheimers disease (AD), multimodal neuroimaging offers complementary signals but VAE-based normative models often (i) fit the healthy reference distribution imperfectly, inflating false positives, and (ii) use posterior aggregation (e.g., PoE/MoE) that...

Feb 8 2026 2602.08077v1
Altered Baseline Brain Network Topology in High-Risk Individuals Progressing to Mild Cognitive Impairment

Background: Identifying early brain-based markers of cognitive decline is critical for preventive strategies in Alzheimer's disease. Individuals with ...

ESUS-AI:a machine learning framework to estimate the most likely embolic source in embolic stroke of undetermined source

Background and Purpose Embolic stroke of undetermined source (ESUS) emains a major diagnostic challenge in vascular neurology, as a substantial propor...

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer's disease

Aging and genetic risk shape the molecular programs that confer cellular vulnerability in Alzheimer's disease (AD), but whether these programs differ ...

A Hybrid CNN and ML Framework for Multi-modal Classification of Movement Disorders Using MRI and Brain Structural Features

Atypical Parkinsonian Disorders (APD), also known as Parkinson-plus syndrome, are a group of neurodegenerative diseases that include progressive supra...

Feb 5 2026 2602.05574v1
Disc-Centric Contrastive Learning for Lumbar Spine Severity Grading

This work examines a disc-centric approach for automated severity grading of lumbar spinal stenosis from sagittal T2-weighted MRI. The method combines...

Feb 5 2026 2602.05738v1
Characterizing Human Semantic Navigation in Concept Production as Trajectories in Embedding Space

Semantic representations can be framed as a structured, dynamic knowledge space through which humans navigate to retrieve and manipulate meaning. To i...

Feb 5 2026 2602.05971v1
Uncertainty-aware personalized estimation of Parkinsons disease severity from longitudinal speech

Parkinsons disease is a progressive neurological disorder characterized by motor impairments whose severity is commonly assessed using the Unified Par...

A consensus spinal cord cell type atlas across mouse, macaque, and human

The spinal cord contains evolutionarily conserved cell types critical for motor function, sensory processing, and autonomic regulation, many of which ...

Live high-content imaging with automated analysis reveals mitochondrial changes during vascular calcification

Mitochondrial dysfunction is implicated in a wide range of disorders, including cancer, neurodegeneration, and cardiovascular diseases. Conventional a...

Predicting Post-Stroke Aphasia Speech Performance from Multimodal Data with Explainable Machine Learning

Aphasia, an acquired language deficit, is the most common post-stroke focal cognitive impairment, and roughly 60% cases become chronic (duration >6 mo...

A quasi-experimental study comparing a VR, computer-based, and face-to-face Alzheimer's embodiment education scenario, "Beatriz".

BACKGROUND AND OBJECTIVES: Effective education on Alzheimer's disease (AD) requires methods fostering empathy, confidence, and knowledge. Artificial i...

Feb 4 2026 41269127
Selectively Augmented Decision Tree for Explainable Dementia Detection

Timely and accurate diagnosis of dementia remains a critical yet challenging task. Although machine learning (ML) techniques have shown considerable p...

APOE ε4 defines a systemic immune endophenotype independent of clinical trajectory in amyotrophic lateral sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is clinically heterogeneous, and genetic modifiers may drive molecular endophenotypes without obvious ...

ExSEnt for explainable dementia detection: disentangling temporal and amplitude-driven complexity boosts EEG-based classification

Early detection of dementia enables timely intervention and better care planning. Electroencephalography, being accessible and noninvasive, offers a p...

NeuroCanvas: VLLM-Powered Robust Seizure Detection by Reformulating Multichannel EEG as Image

Accurate and timely seizure detection from Electroencephalography (EEG) is critical for clinical intervention, yet manual review of long-term recordin...

Feb 4 2026 2602.04769v1
Stroke Lesions as a Rosetta Stone for Language Model Interpretability

Large language models (LLMs) have achieved remarkable capabilities, yet methods to verify which model components are truly necessary for language func...

Feb 3 2026 2602.04074v1
G2DBridge: A Multimodal Framework Linking Genetics to Disease through Imaging Intermediates

Genetic-based risk prediction is becoming increasingly available for a wide range of common diseases thanks to the growth of large-scale biobanks and ...

Brain-SAM: A SAM-based Model Tailored for Brain MRI Lesion Segmentation

Magnetic resonance imaging (MRI) is a cornerstone of modern neuroimaging, where accurate segmentation of brain structures and lesions is essential for...

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