Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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Building an AI-Powered Educational Tool for Exploring Microbial Relationships in Parkinson’s Disease

This paper presents the Neurobiome Navigator, an AI-powered, highly interactive, and easily navigable application designed to help users explore the complex relationships between the human microbiome and Parkinson’s disease (PD). The app focuses on the gut microbiome and the oral microbiome, known to have a strong relationship with PD, as well as impulse control disorders (ICD), a significant non-...

Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke

Recovery from aphasia after stroke is thought to depend on functional reorganization of language processing in surviving brain regions. Many studies have investigated this process, but progress has been impeded by methodological limitations relating to task performance confounds, contrast validity, and sample sizes. Furthermore, few studies have accounted for the complex relationships that exist b...

Evaluating Accuracy and Reasoning Capabilities of Large Language Models for Acute Ischemic Stroke Management

Acute ischemic stroke (AIS) management has evolved substantially over the past two decades, with mechanical thrombectomy adding complexity that requir...

Evaluating the Generalizability of EEG-Based AI Models in Alzheimer’s and Dementia Diagnosis

We thoroughly investigated the generalizability of deep learning models trained on electroencephalography (EEG) data to detect Alzheimer’s disease and...

AI-based synthetic simulation CT generation from diagnostic CT for simulation-free workflow of spinal palliative radiotherapy

Current radiotherapy (RT) planning workflows rely on pre-treatment simulation CT (sCT), which can significantly delay treatment initiation, particular...

Advancing Human Population Genomics with DNA Foundation Models

DNA foundation models offer a new approach to interpret genetic variation, but their potential in population-scale genomics remains untapped. We intro...

Prediction of recurrence and functional status in young ischemic stroke patients: Comparison of machine learning and traditional statistical methods

Ischemic stroke in young adults is a significant social and economic burden. Machine learning (ML) techniques can potentially predict the outcomes of ...

An Indicator Cell Assay-based Multivariate Blood Test for Early Detection of Alzheimer’s Disease

The indicator cell assay platform (iCAP) is a novel next-generation approach for blood-based diagnostics that uses standardized cells as biosensors to...

Real-world deployment of remote sleep monitoring technologies reveals distinct patterns associated with cognitive decline

Sleep disturbances and altered circadian rhythms are well-documented in both physiological and biological studies of dementia. The exact causal relati...

Predicting Acute Cerebrovascular Events in Stroke Alerts Using Large-Language Models and Structured Data

Acute stroke alerts are often activated for non-cerebrovascular conditions, leading to false positives that strain clinical resources and promote diag...

Deep learning-based precision phenotyping of spine curvature identifies novel genetic risk loci for scoliosis in the UK Biobank

Scoliosis is the most common developmental spinal deformity, but its genetic underpinnings remain only partially understood. To enhance the identifica...

Interpretable Transformer Models for rs-fMRI Epilepsy Classification and Biomarker Discovery

Automated interpretation of resting-state fMRI (rs-fMRI) for epilepsy diagnosis remains a challenge. We developed a regularized transformer that model...

Statistical, Multi-scale and Attention-based Layer Pooling of Wav2Vec-2 Speech Embeddings for Parkinson’s Disease Detection

Self-supervised pre-trained speech models such as wav2vec 2.0 provide rich frame-level embeddings that are increasingly used for clinical voice screen...

Neuromorphic Neuromodulation: A Low-Power Edge-Training Framework for the Future of Personalized and Closed-Loop Neurostimulation

Epilepsy affects approximately 1% of the global population, with 30-40% of cases resistant to conventional pharmacological treatments. Current neurost...

Objective Assessment of Microperimetry Exam Using EEG Signals

To test the hypothesis that deep learning can decode single-trial cortical responses from electroencephalography (EEG) to individual, long-duration mi...

Multimodal Machine Learning for Diagnosis of Multiple Sclerosis Using Optical Coherence Tomography in Pediatric Cases

Identifying MS in children early and distinguishing it from other neuroinflammatory conditions of childhood is critical, as early therapeutic interven...

An Unsupervised XAI Framework for Dementia Detection with Context Enrichment

Explainable Artificial Intelligence (XAI) methods enhance the diagnostic efficiency of clinical decision support systems by making the predictions of ...

Toward Reliable Thalamic Segmentation: a rigorous evaluation of automated methods for structural MRI

Automated thalamic nuclear segmentation has contributed towards a shift in neuroimaging analyses from treating the thalamus as a homogeneous, passive ...

Experimental investigation of muscle-tendon unit geometry and kinematics in lower-limb muscles during gait: Current Applications and Future Directions – A Scoping Review

Musculoskeletal (MSK) modeling and ultrasound imaging (USI) are complementary techniques that, when combined with three-dimensional gait analysis (3DG...

Identification of Key Genes Governing the Effects of Physical Activity on Ferroptosis in Alzheimer’s Disease Patients: A Machine Learning-Based Study

Disrupted brain iron metabolism and activated ferroptosis during ageing constitute significant precursors to neurodegenerative diseases. However, whet...

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