Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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Robust Disease Prognosis via Diagnostic Knowledge Preservation: A Sequential Learning Approach

Accurate disease prognosis is essential for patient care but is often hindered by the lack of long-term data. This study explores deep learning training strategies that utilize large, accessible diagnostic datasets to pretrain models aimed at predicting future disease progression in knee osteoarthritis (OA), Alzheimer’s disease (AD), and breast cancer (BC). While diagnostic pretraining improves pr...

Plasma proteomics of seizure-associated changes in epilepsy

Fluid biomarkers are emerging as crucial markers for diagnosis and disease monitoring in neurology. Epilepsy remains an exception despite seizures being known to result in metabolic changes, inflammation, and altered brain protein levels. Insight into how seizures affect the blood proteome is greatly needed. This cross-sectional study used plasma samples from adults aged 18-50 with epilepsy recrui...

A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication

Accurate prognostication of mobility outcomes is essential to guide rehabilitation and manage patient expectations. The prognostic utility of neuroima...

Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts

Sleep electroencephalographic (EEG) microstructures are closely related to cognition and undergo age-dependent changes. However, their multidimensiona...

Plasma Proteomics Linking Primary and Secondary diseases: Insights into Molecular Mediation from UK Biobank Data

Diabetes, hypertension, and dyslipidemia are major risk factors for cardiovascular (CVD), cerebral, and renal diseases (RD). However, the underlying m...

Classifying Obsessive-Compulsive Disorder from Resting-State EEG using Convolutional Neural Networks: A Pilot Study

Objective: Identifying obsessive-compulsive disorder (OCD) using brain data remains challenging. Resting-state electroencephalography (EEG) offers an ...

Discriminating the prodromal stage of multiple sclerosis using longitudinal health administrative claims data and machine learning–based sequence analysis

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Early detection of the prodromal phase could enable timely inte...

Plasma Proteomics for Parkinson’s Disease: Diagnostic Classification, Severity Association, and Therapeutic Hypotheses

Parkinson’s disease lacks reliable early diagnostics and disease-modifying treatments. Blood-based biomarkers can facilitate early detection, symptom ...

Incidentally discovered Covert Cerebrovascular Disease by CT versus MRI: Agreement and Prognostic Value for Stroke and Dementia in a Large Real-World Cohort

Covert cerebrovascular disease (CCD), comprising covert brain infarction (CBI) and white matter disease (WMD), is common in older adults and linked to...

How do clinician and parent reported data differ? An analysis of similarity and difference in the datasets from a cross-syndrome genetics cohort study(GenROC)

Parent/patient-reported datasets provide ready access to phenotypic data for monogenic neurodevelopmental disorders yet their concordance with clinica...

Synthesising Interictal Epileptiform Discharges With Generative Adversarial Network

Interictal epileptiform discharges (IEDs) are reliable biomarkers in electroencephalograms for epilepsy. To automate IED detection, deep learning (DL)...

Evaluation of Care Quality for Atrial Fibrillation Across Non-Interoperable Electronic Health Record Data using a Retrieval-Augmented Generation-enabled Large Language Model

Standardized assessment of clinical quality measures from electronic health records (EHRs) is challenging because information is fragmented across str...

A randomized clinical trial reveals effects of mindfulness and slow breathing on plasma amyloid beta levels

Prior research suggests that meditation may slow brain aging and reduce the risk of Alzheimer’s disease (AD). However, we lack research systematically...

Predicting Future Brain Atrophy Based on Longitudinal MRI

Neuron loss is a key feature of neurodegenerative diseases often leading to brain atrophy detectable through magnetic resonance imaging (MRI). Various...

An Artificial Intelligence Approach to Augmentative and Assistive Communication for Patients with Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) progressively impairs motor functions, making communication increasingly difficult for affected individuals. Howev...

A Self-Explainable Dynamic Risk Monitoring Framework for Predicting Alzheimer’s Disease and Related Dementias

Alzheimer’s Disease and Related Dementias (ADRD) affect millions worldwide and can begin over a decade before symptoms appear. ADRD are generally irre...

Artificial Intelligence Models for Predicting Molecular Pathway Activity in Spinal Cord Injury: A Systematic Review

Spinal cord injury (SCI) remains a devastating neurological condition with high global incidence and minimal curative options. The pathobiology is mul...

A Deep Lightweight Convolutional Neural Network for Detecting Artifacts in Continuous EEG Signals

This study aimed to develop and validate a system of specialized deep lightweight convolutional neural networks (CNN) to accurately detect specific ar...

Measuring Reliability in Locally-deployed Language Model Dysarthric Speech Assessments

Speech is a rich and non-invasive source of clinical information, potentially providing digital biomarkers for neurological disorders such as Parkinso...

Early Detection of Cognitive Decline in Parkinson’s Disease Using Natural Language Processing of Clinical Notes: A Systematic Review and Meta-Analysis Protocol

Cognitive decline affects approximately 40% of Parkinson’s disease (PD) patients within 10 years of diagnosis, progressing to dementia in 80% of patie...

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