Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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Real-Time EEG-Based Epileptic Seizure Prediction Using Artificial Intelligence: A Systematic Review

Epilepsy affects approximately 50 million people worldwide, and seizures remain difficult to predict in onset, severity, and duration. Real-time seizure prediction may enable proactive intervention and improve patient safety and quality of life. Despite the development of high-performing algorithms, translation remains limited by predictive accuracy, interpretability, and generalisability. This sy...

Cerebrospinal fluid proteomics for predictive assessment of Alzheimer’s Disease risk

Alzheimer’s disease (AD) involves early molecular changes beyond amyloid-β (Aβ) and tau, that create heterogeneous disease biology, giving rise to variable disease initiation and highly variable longitudinal trajectories. Accurately predicting trajectories is vital for design of clinical trials and for clinical care, yet current CSF and PET biomarkers provide limited predictive capabilities despit...

Music-Induced Cortical Plasticity: Protocol for a Systematic Review

Music engages sensory, motor, cognitive, and emotional systems, making it a powerful model for studying experience-dependent neuroplasticity. Although...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tuned a foundation model (RETFound) to predict chronological age ...

ALTARN: A Tabular Residual Neural Network for Alzheimer’s Disease Classification and Prediction

Early and accurate prediction of Alzheimer’s disease (AD) from accessible clinical data remains a significant challenge in healthcare. This study prop...

Speech Acoustic Markers Detect APOE-ε4 Carrier Status in Cognitively Healthy Individuals

APOE-ε4, the strongest genetic risk factor for Alzheimer’s disease (AD), is linked to early motor vulnerability, including subtle speech control chang...

Machine learning predicts treatment response to nusinersen in non-sitter Spinal Muscular Atrophy (SMA)

Nusinersen has substantially increased survival and improved disease progression in Spinal Muscular Atrophy (SMA) patients. However, treatment respons...

Early Detection of Cognitive Decline in Parkinson’s Disease Using Natural Language Processing of Speech: Protocol for a Systematic Review and Meta-Analysis

Cognitive decline affects up to 80% of Parkinson’s disease (PD) patients, significantly impacting quality of life. Speech changes occur early in PD an...

Neuro: Machine Learning Optimized to Detect Neurodegenerative Diseases Pilot Study

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that primarily affects cognitive function. Early detection is a crucial factor in...

Epileptic Seizure Detection based on Different Events with XAI and Early Aid System for Patient Aid

The goal of this study is seizure detection in four class datasets for different seizure stages in epileptic patients. An early notification system is...

Predicting future cognitive impairment in preclinical Alzheimer’s disease using multimodal imaging: a multisite machine learning study

Predicting the likelihood of developing Alzheimer’s disease (AD) dementia in at-risk individuals is important for the design of and optimal recruitmen...

Automated Seizure Classification Using Multimodal Large Language Models

Accurately distinguishing between epileptic seizures (ES) and nonepileptic seizures (NES) is a significant clinical challenge that typically requires ...

N2G calibrator: a cross-subject domain adversarial training framework for gait tracking from neural signals in Parkinson’s disease

Adaptive deep brain stimulation has enabled machine learning models to track motor states from neural signals with improved accuracy, aiming to provid...

Uncertainty Quantification of Central Canal Stenosis Deep Learning Classifier from Lumbar Sagittal T2-Weighted MRI

Accurate assessment of the severity of central canal stenosis (CCS) on lumbar spine MRI is critical for clinical decision-making. We evaluated deep le...

Neuromechanical Predictors of Clinical Scores of Balance and Functional Mobility in Chronic Stroke Survivors – A Machine Learning Approach

Clinical tests such as the Berg Balance Scale (BBS) and Timed Up and Go (TUG) are used to assess balance and functional mobility following stroke. The...

Multiregional CT Features Improve Prediction of Immunotherapy Response in Advanced Melanoma

Immunotherapy has improved outcomes for advanced-stage melanoma, however, predictive biomarkers remain limited. We evaluated whether computed tomograp...

Alzheimer’s Disease Stage Classification via Multimodal CNN on EEG Spectrograms and Cube-Drawing Images

Clinicians currently lack reliable tools to determine, at the point of mild cognitive impairment (MCI), which individuals will progress to Alzheimer’s...

The Brain Imaging and Neurophysiology Database: BINDing multimodal neural data into a large-scale repository

The Brain Imaging and Neurophysiology Database (BIND) represents one of the largest multi-institutional, multimodal, clinical neuroimaging repositorie...

From Concept to Code: AI- Powered CODE-ICH Transforming Acute Neurocritical Response for Hemorrhagic Strokes

Intracerebral hemorrhage (ICH) is among the most devastating forms of stroke, characterized by high early mortality and limited time-sensitive treatme...

Lower pre-treatment TMS-evoked cortical reactivity and alpha-band oscillatory dynamics predict efficacy of primary motor cortex neuromodulation for chronic pain

Repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (M1) provides significant pain relief in approximately 45% of p...

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