Obstetrics & Gynecology

Research progress and interfacial adhesion mechanisms of oral delivery systems based on natural polymers.

Oral mucoadhesive delivery is a significant strategy for drug administration due to its capacity to bypass hepatic first-pass metabolism and enhance drug bioavailability. However, the highly moist environment and frequent mechanical stresses in the mouth present substantial challenges to delivery systems. In this review, the oral environment and principal challenges of delivery systems and mechani...

Single-cell profiling and machine learning identify cuproptosis-related fibroblast subpopulations and fibrogenesis modulator AEBP1 in endometriosis.

Endometriosis is characterized by progressive fibrosis and limited therapeutic options. Cuproptosis, a copper-dependent form of regulated cell death, has been implicated in multiple pathological conditions, but its relevance to fibroblast-mediated fibrotic progression in endometriosis remains unclear. Single-cell RNA sequencing data from normal, eutopic, and ectopic endometrial tissues were analyz...

Whole genome methylation profiling of menstrual stem cells identifies novel biomarkers for endometriosis.

BACKGROUND: Endometriosis, despite its high prevalence, is underdiagnosed and poorly managed due to lack of clinically validated biomarkers and pathop...

Progress in Precision Drug Delivery Systems for Neurodegenerative Diseases with Muscle Atrophy.

Neurodegenerative diseases frequently co-occur with skeletal muscle atrophy, creating a complex comorbid condition that significantly accelerates func...

Single-cell and spatial analyses identify a glycolysis-high state driven by STOML2 in epithelial ovarian cancer.

OBJECTIVE: Metabolic heterogeneity contributes to therapeutic resistance and poor prognosis in epithelial ovarian cancer (EOC), yet the regulatory dri...

Advancing equity in endometrial cancer: A narrative synthesis using a cluster-informed framework for resource-stratified implementation.

Endometrial cancer incidence and mortality are rising globally, disproportionately affecting health systems facing diagnostic, therapeutic, and surviv...

MRI- and report-based multimodal model with SHAP-based explanation for preoperative prediction of deep stromal invasion in early-stage cervical cancer.

OBJECTIVES: Depth of stromal invasion (DSI) is a key prognostic factor significantly influencing treatment decisions in early-stage cervical cancer (E...

Coxmos: interpretable survival models for high-dimensional and multi-omic data.

BACKGROUND: Survival analysis in high-dimensional (HD) and multi-block (MB) settings, such as omic and multi-omic studies, poses major methodological ...

Artificial intelligence-driven integration of multi-biofluid omics and clinical phenotype enables stratification of endometrial cancer.

Endometrial cancer (EC) incidence is rising, yet current diagnostics lack precision and scalability. We develop an artificial intelligence (AI)-based ...

Stability of nanosuspensions in drug delivery: mechanisms, characterization strategies, and advanced stabilization approaches.

Poorly soluble drug delivery is a long-standing core challenge in the pharmaceutical field. With a drug loading capacity close to 100% and no requirem...

Metaheuristic optimization of deep CNNs for multi-class diagnosis of cervical cancer and lymphoma.

Accurate and early diagnosis of cancer is critical for determining effective treatment strategies and improving patient survival rates. However, autom...

Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis.

Osteoporosis often lacks accessible screening tools, leading to underdiagnosis and increased fracture risk. We explored the potential of a retinal agi...

Squid-Inspired Multifunctional Retainable Magnetic Soft Robot: Foreign Body Transport and Transmucosal Drug Delivery in Complex Gastrointestinal Environments.

Magnetically controlled soft microrobots, by virtue of their exceptional flexibility and noninvasiveness, exhibit immense potential in the field of mi...

Convolutional neural network analysis of cervical CT images: classification of Kikuchi disease, lymphoma, lymphadenitis, and tuberculosis.

BACKGROUND: Kikuchi disease, lymphoma, lymphadenitis, and tuberculosis are common diseases affecting the head and neck. The causes and treatment metho...

Multidimensional additive manufacturing micro/nanorobots: from elaborate design to smart cargo delivery.

Micro/nanorobots have attracted much attention because of their potential to perform complex tasks with high precision under controlled actuation with...

Recent innovative approaches for drug delivery systems targeting cancer and CNS disorders.

Advancements in drug delivery systems (DDSs) have revolutionized pharmaceutical development by enhancing therapeutic precision, minimizing off-target ...

Transforming Pediatric Care Through AI: Bridging the Digital Divide in Health Informatics.

Health informatics and artificial intelligence (AI) technologies are increasingly influencing pediatric health care delivery across diverse health sys...

Deep-Motion-Net: GNN-based volumetric liver shape reconstruction from single-view 2D projections.

PURPOSE: Internal anatomical motion challenges precise radiation delivery during external beam radiotherapy. Estimating and compensating for anatomica...

Use of artificial neural network optimization for MHD and non-Newtonian peritoneal Jeffery nanofluid dynamics on female reproductive health.

The dynamics of peritoneal fluid has vital applications in various physiological functions, particularly in female reproductive physiology, which modu...

Model-guided design of lymphatic drug delivery systems using osmotic pressure, viscosity and lymph node size.

Metastatic lymph nodes (LNs) represent a major barrier to effective drug delivery in cancer therapy. To address this challenge, a lymphatic drug deliv...