Latest AI and machine learning research in obesity for healthcare professionals.
Drug repurposing, the application of approved or shelved compounds to new therapeutic indications, offers a cost- and time-efficient alternative to de novo drug discovery. However, the systematic identification of repurposing candidates from the rapidly expanding body of clinical trial data remains a significant challenge. Here we present a publicly accessible AI-powered tool that mines the Clinic...
Background and rationale: Knee osteoarthritis (KOA) is a leading cause of lower limb disability worldwide, characterized by functional limitations, stiffness and pain. The incidence of KOA is especially tied to age and obesity. It is a disabling disease that often makes patients less physically active, thus increasing the risk of other diseases and mortality1. The clinical diagnosis of KOA is base...
Background The European Association for the Study of the Liver (ESAL) - Steatotic Liver Disease (SLD) screening algorithm involves two steps; initial ...
Background: Machine learning models for stroke mortality prediction typically treat each time horizon independently and use flat tabular features that...
Motivation: Parent of Origin Effects (POEs), where the effect of an an allele on a phenotype differs based on maternal or paternal inheritance implica...
The escalating demand for mental healthcare, driven by rising societal stress, highlights the limitations of traditional psychiatric diagnostics. Conv...
Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) frequently co-occur in Veterans, producing overlapping symptoms and shared auton...
The state-of-the-art generative models, such as CycleGAN, Pix2Pix, and diffusion models have demonstrated remarkable performance in the face generatio...
Objective: Despite the complex and non-linear progression of diabetes, its shared pathways with atherosclerotic cardiovascular disease (ASCVD) are con...
Suicidal ideation in obsessive-compulsive disorder (OCD) is common and clinically significant, yet much of the existing literature conceptualizes suic...
Osteoporosis is often called a silent disease because it progresses without symptoms until a fracture occurs, posing a serious, yet frequently overloo...
Importance Prognostic tools beyond staging are needed to guide treatment and counseling in head and neck squamous cell carcinoma (HNSCC). Objective To...
Background: Non-communicable diseases (NCDs) represent a critical public health challenge in Kenya, responsible for over 50% of inpatient admissions a...
Objective: To systematically evaluate pathway-informed polygenic risk score (PRS) strategies and determine which approaches most effectively leverage ...
Objectives: Diabetes affects over 500 million people globally and glycemia is inadequately managed. Metformin is the most frequently prescribed initia...
Cells that store lipids for other cells or organs can contain ''giant'' or large lipid droplets (LLDs) greater than 2 m in diameter. In this study, hu...
Adolescence is a critical developmental window for the emergence of substance use and psychosis-spectrum symptoms, yet early risk for these outcomes r...
Diabetes is a global health burden, and early detection is critical for timely intervention. This study explores a non-invasive, data-driven framework...
Background: Heart failure (HF) is a major contributor to inpatient hospital utilization, with persistently high 30-day readmission rates. Existing pre...
Objective To assess serum 25-hydroxyvitamin D [25(OH)D] levels in a health examination population in Guiyang, a low-latitude, high-altitude, and cloud...