Oncology/Hematology

Latest AI and machine learning research in oncology/hematology for healthcare professionals.

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Incorporating artificial intelligence into imaging for surveillance and diagnosis of liver cancer: Innovations, challenges, and clinical translation.

Primary liver cancer, mainly hepatocellular carcinoma and intrahepatic cholangiocarcinoma, remains a leading cause of cancer mortality worldwide. Early detection is crucial for curative treatment, yet current surveillance and diagnostic strategies, primarily ultrasound surveillance and contrast-enhanced CT or MRI, suffer from operator dependence, limited sensitivity, and interpretive variability. ...

Jan 30 2026 41616271

Clinical Validation of Deep Learning-Accelerated versus Wave-CAIPI Postcontrast 3D T1-MPRAGE for Evaluation of Intracranial Enhancing Lesions.

BACKGROUND AND PURPOSE: Deep learning (DL) reconstruction methods have shown promise in accelerating 2D MRI sequences but have yet to be extensively validated for routine 3D volumetric MRI applications. Our purpose was to assess the diagnostic quality of a novel DL-accelerated 3D T1-MPRAGE compared with a state-of-the-art wave-controlled aliasing in parallel imaging (Wave-CAIPI) accelerated 3D T1-...

Jan 30 2026 41617400
XRepDDA: An Interpretable Drug-Disease Association Prediction Framework Leveraging Pretrained Chemical Language Models.

Drug repositioning aims to identify new indications for existing drugs, offering a cost-effective and time-efficient strategy for therapeutic developm...

Jan 30 2026 41617662
Identification of diagnostic and prognostic biomarkers in lung adenocarcinoma through integrated bioinformatics analysis and real time PCR validation.

Lung cancer is the third most common cancer in the US with a 5-year survival rate of 17%. Non-small cell lung cancer, especially adenocarcinoma, preva...

Jan 30 2026 41617774
Multimodal deep learning for laryngeal squamous cell carcinoma staging using CT and laryngoscopy.

OBJECTIVES: To develop and validate a multimodal deep learning model integrating clinical data, contrast-enhanced CT, and laryngoscopic images for dif...

Jan 30 2026 41617832
A clinically applicable and generalizable deep learning model for anterior mediastinal tumors in CT images across multiple institutions.

Rare diseases are often difficult to diagnose, and their scarcity also makes it challenging to develop deep learning models for them due to limited la...

Jan 30 2026 41617892
The METTL3-IGF2BP3 axis drives osteosarcoma progression by enhancing ID1 mRNA stability.

OBJECTIVE: Osteosarcoma (OS) is a highly aggressive malignant bone tumor. While ID1 plays a critical role in OS progression, the underlying mechanisms...

Jan 30 2026 41618233
μPharma: A microfluidic, AI-driven pharmacotyping platform for single-cell drug sensitivity prediction in leukemia.

BACKGROUND: Pharmacotyping, the ex vivo measurement of tumor cell responses to drugs, is particularly important for cancers lacking actionable genomic...

Jan 30 2026 41619724
A deep state-space analysis framework for cancer patient latent state estimation and classification from EHR time-series data.

Advancements in deep learning technologies and an increase in medical data have enhanced the accuracy of disease diagnosis and treatment strategies. N...

Jan 30 2026 41616002
Minimally Invasive / Robotic Surgery for Hepatobiliary Cancer.

Minimally invasive liver surgery (MILS), including laparoscopic liver surgery and robotic liver surgery, has come a long way in the management of prim...

Jan 29 2026 42264699
Feasibility of single-phase DECT as an alternative to triple-phase CT for imaging-defined risk factors assessment in neuroblastoma for dose reduction.

OBJECTIVE: To investigate the feasibility of evaluating Imaging-Defined Risk Factors (IDRFs) in Neuroblastoma (NB) patients using venous-phase (VP)-on...

Jan 29 2026 41657758
Response to venom immunotherapy: Exploratory retrospective machine learning clustering analysis.

BACKGROUND: Hymenoptera venom immunotherapy is an established treatment for severe allergic reactions, aiming to modulate the immune response and redu...

Jan 29 2026 41778267
Education as a Tool to Navigate Changing Technology in Radiation Oncology.

While technological innovation in radiation therapy (RT) continues to accelerate, safe and equitable adoption of emerging tools is reliant on the read...

Jan 29 2026 41616403
Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD.

Chronic obstructive pulmonary disease (COPD) and non-small-cell lung cancer (NSCLC) often coexist; here, the shared mitochondrial drivers were investi...

Jan 29 2026 41732265
Multi-cohort and single-cell profiling of aging genes reveals prognostic and therapeutic targets in breast cancer.

Aging-related transcriptional programs shape breast cancer progression, immune regulation, and therapeutic response. We integrated curated aging-assoc...

Jan 29 2026 41732271
Multi-omics analysis reveals features improving outcomes and immunotherapy resistance in MSS colorectal cancer.

In contrast to the MSI-H subtype, most microsatellite-stable (MSS) colorectal cancer (CRC) patients exhibit poor prognosis and limited responsiveness ...

Jan 29 2026 41852723
AI and Big Data in Oncology: A Physician-Centered Perspective on Emerging Clinical and Research Applications.

The convergence of artificial intelligence (AI) and big data is reshaping contemporary oncology by enabling the integration of multimodal information ...

Jan 29 2026 41624314
Liquid biopsy biomarkers for accurate detection of malignant pulmonary nodules: a meta-analytic approach.

UNLABELLED: Pulmonary nodules are a common radiological finding that can be classified as either benign or Malignant, with significant clinical implic...

Jan 29 2026 41612093
Pathology of peripheral neuroblastic tumors.

Neuroblastoma is the most prevalent extracranial solid tumor in pediatric age populations worldwide and the most common neoplastic disease diagnosed i...

Jan 29 2026 41612478
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