Oncology/Hematology

Latest AI and machine learning research in oncology/hematology for healthcare professionals.

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Living breast cancer subtype classification by membrane-interfacing 3D surface-enhanced Raman spectroscopy substrates with multivariate analysis.

Surface-enhanced Raman spectroscopy (SERS) is a non-destructive and highly sensitive technique widely used for analyzing complex biological samples. However, conventional SERS approaches for living cell analysis face significant challenges. In particular, nanoparticle-based intracellular probes can induce cytotoxicity, and attempts to use 3D protruding nanostructures to interrogate cells externall...

Oct 16 2025 41108934

Predictive prioritization of enhancers associated with pancreatic disease risk.

Genetic and epigenetic variation in enhancers is associated with disease susceptibility; however, linking enhancers to target genes and predicting enhancer dysfunction remain challenging. We mapped enhancer-promoter interactions in human pancreas using 3D chromatin assays across 28 donors and five cell types. Using a network approach, we parsed these interactions into enhancer-promoter tree models...

Oct 16 2025 41106391
Evaluating the Clinical Competence of Large Language Models in Prostate Cancer Management: A Comparative Study of DeepSeek-R1 and ChatGPT.

BACKGROUND: Large language models (LLMs) have gained prominence in medical applications, yet their performance in specialized clinical tasks remains u...

Oct 15 2025 41094286
A hybrid decision support system using rule-based and AI methods: the OnCATs knowledge-based framework.

BACKGROUND AND SIGNIFICANCE: Clinical decision support systems (CDSS) can improve evidence-based oncology care, but many rely on opaque AI models that...

Oct 14 2025 41124940
Nodular Growths of NF2 -Related Schwannomatosis Vestibular Schwannoma: Clinical and Therapeutical Consequences.

BACKGROUND AND OBJECTIVES: Neurofibromatosis type 2-related schwannomatosis ( NF2 -SWN) is marked by the growth of bilateral vestibular schwannoma (VS...

Oct 13 2025 41081518
Development and validation of a nomogram combining PI-RADS v2.1 and clinical indicators for the diagnosis of prostate cancer in patients with PSA ≤ 20 ng/mL.

PURPOSE: This investigation focused on developing a predictive clinical tool that combines biparametric MRI-derived PI-RADS v2.1 assessments with pati...

Oct 13 2025 41081880
Artificial Intelligence 3D Augmented Reality-guided Robotic Prostatectomy Versus Cognitive MRI Intervention: Results of the Prospective Randomized RIDERS Trial.

BACKGROUND AND OBJECTIVE: Three-dimensional (3D) augmented reality (AR) and artificial intelligence (AI) technologies have recently been introduced to...

Oct 13 2025 41087293
Deep learning enhanced label-free cervical screening via stimulated Raman cytology.

Cervical cancer screening remains pivotal for early detection and effective disease management, yet conventional cytopathological methods relying on s...

Oct 13 2025 41109050
Breaking the bottleneck of asthma treatment: the future of omni-targeted therapy.

BACKGROUND: Bronchial asthma is a complex, highly heterogeneous disease involving multiple pathological mechanisms and inflammatory pathways. Traditio...

Oct 12 2025 41086983
Predictive value of artificial intelligence-based quantitative CT feature analysis for diagnosing the pathological types of pulmonary nodules.

OBJECTIVES: Accurate preoperative classification of pulmonary nodules (PNs) is critical for guiding clinical decision-making and preventing overtreatm...

Oct 11 2025 41076471
Machine Learning to Predict Extranodal Extension in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

OBJECTIVE: To evaluate the clinical utility of machine learning algorithms (MLAs) in diagnosing extra-nodal extension (ENE) using CT imaging in HNSCC....

Oct 10 2025 41070703
Ovarian cancer detection from mutual information-ranked clinical biomarkers using an explainable attention-based residual multilayer perceptron.

Ovarian cancer is a major health concern for women, contributing to substantial mortality and morbidity. Timely identification of ovarian cancer is cr...

Oct 10 2025 41086647
Co-mapping clonal and transcriptional heterogeneity in somatic evolution via GoT-Multi.

Somatic evolution leads to clonal heterogeneity, which fuels cancer progression and therapy resistance. To decipher the consequences of clonal heterog...

Oct 10 2025 41075791
Comparative analysis of convolutional neural network models for the histopathological differentiation of acinic cell carcinoma and secretory carcinoma.

OBJECTIVE: Although artificial intelligence tools show promise for enhancing the diagnosis of head and neck lesions, few studies have tested these res...

Oct 9 2025 41591939
Predicting sentinel lymph node metastasis in melanoma patients: A machine learning-based predictive model.

BACKGROUND: Risk factors for sentinel lymph node (SLN) metastasis in melanoma have been studied. However, there remains a lack of widely applicable mo...

Oct 9 2025 41256334
Consensus position statements for the standardized application of histological grading and staging systems in MASH clinical trials.

BACKGROUND & AIMS: Assessment of histologic disease activity (grading) and fibrosis (staging) is a prerequisite for patient selection and evaluation o...

Oct 8 2025 41072805
Artificial intelligence predicts c-KIT exon 11 genotype by phenotype in canine cutaneous mast cell tumors: Can human observers learn it?

Canine cutaneous mast cell tumors (ccMCTs) are frequent neoplasms with variable biological behaviors. Internal tandem duplication mutations in c-KIT e...

Oct 8 2025 41059708
Cervical cancer diagnostics: non-coding RNAs and biosensors to AI-derived methods.

Cervical cancer ranks fourth in terms of cancer mortality among women. The most important risk factor for cervical cancer is infection with HPV 16 and...

Oct 8 2025 41072569
Genomic and Transcriptomic Profiling of High-risk Bladder Cancer Reveals Diverse Molecular and Microenvironment Ecosystems.

BACKGROUND AND OBJECTIVE: High-risk bladder cancer recurs in 30% of cases and causes fatal outcomes in 10% within 2 yr despite surgical resection, end...

Oct 7 2025 41058365
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