Oncology/Hematology

Spatially Informed Graph Structure Learning Extracts Insights from Spatial Transcriptomics.

Embeddings derived from cell graphs hold significant potential for exploring spatial transcriptomics (ST) datasets. Nevertheless, existing methodologies rely on a graph structure defined by spatial proximity, which inadequately represents the diversity inherent in cell-cell interactions (CCIs). This study introduces STAGUE, an innovative framework that concurrently learns a cell graph structure an...

SGLMDA: A Subgraph Learning-Based Method for miRNA-Disease Association Prediction.

MicroRNAs (miRNA) are endogenous non-coding RNAs, typically around 23 nucleotides in length. Many miRNAs have been founded to play crucial roles in gene regulation though post-transcriptional repression in animals. Existing studies suggest that the dysregulation of miRNA is closely associated with many human diseases. Discovering novel associations between miRNAs and diseases is essential for adva...

Analysis of Cancer-Associated Mutations of POLB Using Machine Learning and Bioinformatics.

DNA damage is a critical factor in the onset and progression of cancer. When DNA is damaged, the number of genetic mutations increases, making it nece...

Development of HepatIA: A computed tomography annotation platform and database for artificial intelligence training in hepatocellular carcinoma detection at a Brazilian tertiary teaching hospital.

BACKGROUND: Hepatocellular carcinoma (HCC) is a prevalent tumor with high mortality rates. Computed tomography (CT) is crucial in the non-invasive dia...

Graph neural networks in multi-stained pathological imaging: extended comparative analysis of Radiomic features.

PURPOSE: This study investigates the application of Radiomic features within graph neural networks (GNNs) for the classification of multiple-epitope-l...

Improving the diagnostic strategy for thyroid nodules: a combination of artificial intelligence-based computer-aided diagnosis system and shear wave elastography.

PURPOSE: Thyroid nodules are highly prevalent in the general population, posing a clinical challenge in accurately distinguishing between benign and m...

A review of deep learning approaches for multimodal image segmentation of liver cancer.

This review examines the recent developments in deep learning (DL) techniques applied to multimodal fusion image segmentation for liver cancer. Hepato...

Prediction of pathological complete response to chemotherapy for breast cancer using deep neural network with uncertainty quantification.

BACKGROUND: The I-SPY 2 trial is a national-wide, multi-institutional clinical trial designed to evaluate multiple new therapeutic drugs for high-risk...

Ranking attention multiple instance learning for lymph node metastasis prediction on multicenter cervical cancer MRI.

PURPOSE: In the current clinical diagnostic process, the gold standard for lymph node metastasis (LNM) diagnosis is histopathological examination foll...

Artificial intelligence for detection and characterization of focal hepatic lesions: a review.

Focal liver lesions (FLL) are common incidental findings in abdominal imaging. While the majority of FLLs are benign and asymptomatic, some can be mal...

Bulk integrated single-cell-spatial transcriptomics reveals the impact of preoperative chemotherapy on cancer-associated fibroblasts and tumor cells in colorectal cancer, and construction of related predictive models using machine learning.

BACKGROUND: Preoperative chemotherapy (PC) is an important component of Colorectal cancer (CRC) treatment, but its effects on the biological functions...

A survey on cell nuclei instance segmentation and classification: Leveraging context and attention.

Nuclear-derived morphological features and biomarkers provide relevant insights regarding the tumour microenvironment, while also allowing diagnosis a...

MixUNETR: A U-shaped network based on W-MSA and depth-wise convolution with channel and spatial interactions for zonal prostate segmentation in MRI.

Magnetic resonance imaging (MRI) plays a pivotal role in diagnosing and staging prostate cancer. Precise delineation of the peripheral zone (PZ) and t...

Computed Tomography-Based Radiomics with Machine Learning Outperforms Radiologist Assessment in Estimating Colorectal Liver Metastases Pathologic Response After Chemotherapy.

OBJECTIVES: This study was designed to assess computed tomography (CT)-based radiomics of colorectal liver metastases (CRLM), extracted from posttreat...

Ensemble approach of deep learning models for binary and multiclass classification of histopathological images for breast cancer.

Breast cancer (BC) is the most frequently occurring cancer disease observed in women after lung cancer. Out of different stages, invasive ductal BC ca...

Enhanced cancer classification and critical feature visualization using Raman spectroscopy and convolutional neural networks.

Cell misuse and cross-contamination pose a significant threat to the accuracy of cell research outcomes, often leading to the wasteful expenditure of ...

Predicting remission after acute phase pharmacotherapy in patients with bipolar I depression: A machine learning approach with cross-trial and cross-drug replication.

OBJECTIVES: Interpatient variability in bipolar I depression (BP-D) symptoms challenges the ability to predict pharmacotherapeutic outcomes. A machine...

Construction and validation of a nomogram prediction model for the catheter-related thrombosis risk of central venous access devices in patients with cancer: a prospective machine learning study.

Central venous access devices (CVADs) are integral to cancer treatment. However, catheter-related thrombosis (CRT) poses a considerable risk to patien...

Prognostic insights after surgery for advances in understanding signet ring cell gastric cancer: a machine learning approach.

BACKGROUND: Signet ring cell (SRC) gastric carcinoma is traditionally associated with a poor prognosis. However, the literature has presented contradi...

A Lightweight Method for Breast Cancer Detection Using Thermography Images with Optimized CNN Feature and Efficient Classification.

Breast cancer is a prominent cause of death among women worldwide. Infrared thermography, due to its cost-effectiveness and non-ionizing radiation, ha...