Oncology/Hematology

Association of sarcopenia with treatment tolerance in older adults with acute myeloid leukemia using artificial intelligence computed tomography-segmentation and a geriatric assessment.

Exploratory immunomonitoring during radiochemotherapy in HNSCC and machine-learning reveal immune parameters associated with disease-free survival.

Immunological biomarkers are increasingly relevant for personalized cancer treatment, but peripheral...

Apparent diffusion coefficient radiomics for differentiating benign and malignant PI-RADS 3-5 prostate lesions: external validation.

PURPOSE: To develop and externally validate a simplified apparent diffusion coefficient (ADC)-based ...

Deep Learning Algorithm-Reconstructed Triple-Rule-Out CT: Image Quality and Performance in Evaluating Coronary Lumen Stenosis.

To assess radiation burden and contrast medium load, image quality, and the performance of AI-reader...

Multi-task Deep Learning via UNETR for PSMA PET/CT Image for Prostate Cancer: Simultaneous Assessment of Prostate Cancer Disease Burden, Treatment Selection and Survival Outcomes.

Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) pr...

Multi-Omics-Driven Insights into Cancer Biology and Therapeutic Targeting.

The increasing biological complexity and heterogeneity of cancer have driven a shift in oncology dru...

Artificial intelligence for translational personalized neoantigen cancer vaccine development.

Personalized neoantigen cancer vaccine is a promising strategy for precision immunotherapy by target...

Knowledge-driven multimodal mutual learning for cell line-targeted anticancer peptide prediction.

MOTIVATION: As unique drugs positioned between small and macro molecules, anticancer peptides (ACPs)...

Integration of Bulk RNA Sequencing and Single-Cell Sequencing to Identify Prognostic Genes Associated With MCDRGs in Neuroblastoma.

Neuroblastoma (NB) is a common pediatric tumor that exhibits significant clinical heterogeneity and ...

Patient-Derived Organoid and Single-Cell Multiomics Reveal Evolution Driven by CEACAM6/KRT19-Mediated Heterogeneity.

Colorectal cancer (CRC) remains a leading cause of cancer mortality globally, with therapeutic effic...

Machine learning provides individualized prediction of outcomes after first complete remission without allo-HSCT consolidation in adult acute myeloid leukemia-A HARMONY study.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for a ...

Artificial intelligence-based detection of small and intermediate-to-large lymphocytes for cytologic diagnosis of canine lymphoma.

Lymphoma is a common cancer in dogs, which often presents as generalized peripheral lymphadenopathy....

Multi-omics, machine learning, and molecular simulation identify CD44 as a candidate target in endocrine-disrupting chemical-associated thyroid cancer progression.

Endocrine-disrupting chemicals (EDCs) are widely present in the environment and consumer products an...

Prognostic Models and Predictors of Recurrence in Resectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis.

We systematically reviewed prognostic models for recurrence after curative-intent locoregional treat...

Machine learning-integrated explainable artificial intelligence for survival prediction in urothelial carcinoma with enfortumab vedotin: an exploratory real-world analysis.

BACKGROUND: Enfortumab vedotin (EV) has transformed treatment for advanced urothelial carcinoma (aUC...

Feasibility of reducing radiation dose and contrast dose while improving image quality in dual-energy CT pulmonary angiography : Use of low-energy virtual monochromatic images with deep learning image reconstruction algorithm.

BACKGROUND: We explored the feasibility of reducing both radiation and contrast doses while improvin...

Emerging frontiers and challenges of artificial intelligence in PSMA-PET imaging: pioneering a new chapter in prostate cancer care.

Prostate-specific membrane antigen positron emission tomography (PSMA-PET) has become pivotal in pro...

Non-Oncology Biomarkers in Precision Medicine: A Narrative Review.

Precision medicine has revolutionized oncology by leveraging biomarkers for individualized therapy s...

Harnessing machine learning, docking and molecular dynamics for the virtual screening of compounds as CDK4/6 dual inhibitors.

Cyclin-dependent kinases 4 and 6 (CDK4/6) are pivotal regulators of the G1-to-S phase transition, an...

Integrative single-cell and spatial transcriptomic analysis reveals 4-HNE-related stromal remodeling in lung adenocarcinoma.

BACKGROUND: 4-HNE is a lipid peroxidation product involved in oxidative stress, tumor microenvironme...

Targeting autophagy-dependent cell death in cancer therapy: An update on small-molecule compounds.

Autophagy-dependent cell death (ADCD) is a regulated form of cell death that relies on the autophagi...