Oncology/Hematology

Predicting invasion in early-stage ground-glass opacity pulmonary adenocarcinoma: a radiomics-based machine learning approach.

BACKGROUND: To design a pulmonary ground-glass nodules (GGN) classification method based on computed tomography (CT) radiomics and machine learning for prediction of invasion in early-stage ground-glass opacity (GGO) pulmonary adenocarcinoma.

Integrating multi-omics and machine learning survival frameworks to build a prognostic model based on immune function and cell death patterns in a lung adenocarcinoma cohort.

INTRODUCTION: The programmed cell death (PCD) plays a key role in the development and progression of lung adenocarcinoma. In addition, immune-related genes also play a crucial role in cancer progression and patient prognosis. However, further studies are needed to investigate the prognostic significance of the interaction between immune-related genes and cell death in LUAD.

Convolutional Neural Networks for Segmentation of Pleural Mesothelioma: Analysis of Probability Map Thresholds (CALGB 30901, Alliance).

The purpose of this study was to evaluate the impact of probability map threshold on pleural mesothelioma (PM) tumor delineations generated using a co...

Bioinformatics challenges for profiling the microbiome in cancer: pitfalls and opportunities.

Increasing evidence suggests that the human microbiome plays an important role in cancer risk and treatment. Untargeted 'omics' techniques have accele...

Upconversion and NIR-II luminescent rare earth nanoparticles combined with machine learning for cancer theranostics.

How to develop contrast agents for cancer theranostics is a meaningful and challenging endeavor, and rare earth nanoparticles (RENPs) may provide a po...

Assessing the Reporting Quality of Machine Learning Algorithms in Head and Neck Oncology.

OBJECTIVE: This study aimed to assess reporting quality of machine learning (ML) algorithms in the head and neck oncology literature using the TRIPOD-...

Development of Machine Learning Models for Predicting the 1-Year Risk of Reoperation After Lower Limb Oncological Resection and Endoprosthetic Reconstruction Based on Data From the PARITY Trial.

BACKGROUND: Oncological resection and reconstruction involving the lower extremities commonly lead to reoperations that impact patient outcomes and he...

Towards explainable oral cancer recognition: Screening on imperfect images via Informed Deep Learning and Case-Based Reasoning.

Oral squamous cell carcinoma recognition presents a challenge due to late diagnosis and costly data acquisition. A cost-efficient, computerized screen...

Multimodal radiomics-based methods using deep learning for prediction of brain metastasis in non-small cell lung cancer withF-FDG PET/CT images.

. Approximately 57% of non-small cell lung cancer (NSCLC) patients face a 20% risk of brain metastases (BMs). The delivery of drugs to the central ner...

AI-derived comparative assessment of the performance of pathogenicity prediction tools on missense variants of breast cancer genes.

Single nucleotide variants (SNVs) can exert substantial and extremely variable impacts on various cellular functions, making accurate predictions of t...

Renal Cell Carcinoma Discrimination through Attenuated Total Reflection Fourier Transform Infrared Spectroscopy of Dried Human Urine and Machine Learning Techniques.

Renal cell carcinoma (RCC) is the sixth most common cancer in men and is often asymptomatic, leading to incidental detection in advanced disease stage...

piRNA in Machine-Learning-Based Diagnostics of Colorectal Cancer.

Objective biomarkers are crucial for early diagnosis to promote treatment and raise survival rates for diseases. With the smallest non-coding RNAs-piw...

Contrast-Enhanced Computed Tomography-Based Machine Learning Radiomics Predicts IDH1 Expression and Clinical Prognosis in Head and Neck Squamous Cell Carcinoma.

RATIONALE AND OBJECTIVES: Isocitrate dehydrogenase 1 (IDH1) is a potential therapeutic target across various tumor types. Here, we aimed to devise a r...

Applying deep learning-based ensemble model to [F]-FDG-PET-radiomic features for differentiating benign from malignant parotid gland diseases.

OBJECTIVES: To develop and identify machine learning (ML) models using pretreatment 2-deoxy-2-[F]fluoro-D-glucose ([F]-FDG)-positron emission tomograp...

Diagnostic Value of Magnetic Resonance Imaging Radiomics and Machine-learning in Grading Soft Tissue Sarcoma: A Mini-review on the Current State.

Soft tissue sarcomas (STS) are a heterogeneous group of rare malignant tumors. Tumor grade might be underestimated in biopsy due to intratumoral heter...

MYC Rearrangement Prediction From LYSA Whole Slide Images in Large B-Cell Lymphoma: A Multicentric Validation of Self-supervised Deep Learning Models.

Large B-cell lymphoma (LBCL) is a heterogeneous lymphoid malignancy in which MYC gene rearrangement (MYC-R) is associated with a poor prognosis, promp...

Deep learning Radiomics Based on Two-Dimensional Ultrasound for Predicting the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer.

We investigate the predictive value of a comprehensive model based on preoperative ultrasound radiomics, deep learning, and clinical features for path...

The transformative potential of AI-driven CRISPR-Cas9 genome editing to enhance CAR T-cell therapy.

This narrative review examines the promising potential of integrating artificial intelligence (AI) with CRISPR-Cas9 genome editing to advance CAR T-ce...

Deep Learning-Based Image Classification and Segmentation on Digital Histopathology for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

BACKGROUND: Artificial intelligence (AI)-based tools have shown promise in histopathology image analysis in improving the accuracy of oral squamous ce...

Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?

Despite implementing hundreds of strategies, cancer drug development suffers from a 95% failure rate over 30 years, with only 30% of approved cancer d...