Oncology/Hematology

Latest AI and machine learning research in oncology/hematology for healthcare professionals.

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Cyclosporine in hematological disorders: mechanisms, clinical practice and emerging advances.

Cyclosporine A (CsA) functions as a calcineurin inhibitor that perturbs T cell activation via calcineurin-nuclear factor of activated T cells (CaN-NFAT) signaling inhibitors, establishing its central role in hematological therapeutics. This review delineates the contemporary applications and mechanistic underpinnings of CsA across acquired bone marrow failure syndromes spanning severe and non-seve...

May 29 2026 42215807

Exercise-related genes predicts overall survival and tumor immune microenvironment, and identifies the biological role of SLC52A2 in breast cancer.

BACKGROUND: Breast cancer (BRCA) is the most common malignant tumor in women, with prognoses differing markedly by molecular subtype. Exercise is known to be related to tumor occurrence and progression, yet its role in BRCA remains understudied. This research seeks to explore the prognostic and immunomodulatory functions of exercise-related genes (ERGs) in BRCA, and their links to molecular subtyp...

May 29 2026 42215809
Integrative multi-omics, machine learning, and experimental validation reveal that TPM1 suppresses M2 macrophage polarization and enhances chemosensitivity in acute myeloid leukemia.

BACKGROUND: Acute myeloid leukemia (AML) remains a therapeutic challenge due to chemoresistance and immunosuppression. This study aimed to discover no...

May 29 2026 42215832
A novel prognostic model based on MVIRGs identifies ANGPT2 as a key target driving the malignant progression of HCC.

BACKGROUND: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with high recurrence and limited therapies. Microvascular invasion (MVI) is a...

May 29 2026 42215875
The impact of an artificial intelligence (AI)-assisted education program on mental health, social support and quality of life in older individuals with head and neck cancer: study protocol of a randomized controlled trial.

BACKGROUND: Head and neck cancer (HNC) is a common malignant tumor, and its treatment often leads to functional impairments in speech, swallowing, and...

May 29 2026 42215892
MSTM-Net: a two-stage prostate cancer segmentation network based on swin-transformer-mamba architecture.

BACKGROUND: Magnetic resonance imaging (MRI) has become a core imaging modality for prostate cancer screening and diagnosis. Accurate and automatic se...

May 29 2026 42215932
Network toxicology and bioinformatics reveal potential molecular links between cadmium exposure and pancreatic cancer.

BACKGROUND: Environmental cadmium (Cd) pollution poses a severe threat to human health due to its strong bioaccumulation and high carcinogenicity. Alt...

May 29 2026 42216024
DNA damage response signature-based prognostic genes for intrahepatic cholangiocarcinoma: a combined analysis of machine learning and biological experiments.

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive subtype of primary liver cancer with insidious onset, early metastasis, and p...

May 29 2026 42216034
Machine learning models based on magnetic resonance imaging for predicting Lymphovascular Invasion in Invasive Breast Cancer.

OBJECTIVES: Treatment strategies for invasive breast cancer require accurate lymphovascular invasion (LVI) predictions. This study aimed to investigat...

May 29 2026 42213726
ROI-guided virtual narrow band imaging for laryngeal cancer screening.

White light laryngoscopy is widely available but can miss subtle vascular changes associated with early laryngeal neoplasia. We developed a region-of-...

May 28 2026 42256307
Human factors validation study of an artificial neural network‑based preoperative decision‑support tool for noninvasive lymph node staging (NILS) in women with primary breast cancer (ISRCTN99301435).

BACKGROUND: The integration of clinical decision support tools in medical practice is challenging and must be carefully undertaken, especially in canc...

May 28 2026 42204510
Pan-cancer spatial atlas of tertiary lymphoid structures.

Tertiary lymphoid structures (TLSs) are critical regulators of antitumor immunity, yet their spatial organization, maturation, and clinical relevance ...

May 28 2026 42207882
Artificial Intelligence in Hospice and Palliative Care: A Systematic Review of Its Role in Interprofessional Shared Decision-Making Care.

BackgroundArtificial intelligence (AI) is increasingly integrated into hospice and palliative care to support clinical decision-making across clinicia...

May 28 2026 42208020
Improving Compton imaging of 478 keV prompt gamma-ray in boron neutron capture therapy with neural network-based event filtering: a simulation study.

Objective.Boron neutron capture therapy (BNCT) is a promising radiotherapy modality that effectively targets cancer cells through boron neutron captur...

May 28 2026 42208575
Quantum-inspired optimization of transformer-capsule networks for accurate brain tumor segmentation and classification.

Brain tumors represent one of the deadliest types of neurological diseases, a fact that makes early accurate diagnosis essential for the survival of p...

May 28 2026 42209605
Lactylation-related prognostic signature characterized in pancreatic ductal adenocarcinoma through public scRNA-seq dataset and machine learning algorithms: the TOP2A-H3K18la-NQO1 axis orchestrates malignant progression.

BACKGROUND: Lactate promotes histone lactylation, which affects protein transcription and translation, thereby influencing tumour cell progression. Ho...

May 28 2026 42209673
CAHA-Net: A novel MR image classification model based on DenseNet incorporating coordinate attention and hybrid augmentation.

Traditional diagnostic approaches are time-consuming and labor-intensive, and the field currently lacks a comprehensive evaluation of mainstream model...

May 28 2026 42209768
Radiation dose has no significant impact on CT-based bone mineral density measurements in a large-animal model.

Bone mineral density (BMD) is a biomarker for frailty, and CT-derived radiodensity can be extracted fully automatically as a surrogate. Because these ...

May 28 2026 42209788
Artificial intelligence in cancer immunotherapy: current trends in predicting response and personalizing treatment.

Artificial intelligence (AI) can transform cancer immunotherapy by enabling more accurate prediction of treatment responses, the discovery of specific...

May 28 2026 42209845
Artificial intelligence and transforming cancer care.

Artificial Intelligence (AI) is reshaping oncology by addressing key limitations in traditional cancer care and enabling data-driven, personalized app...

May 28 2026 42209847
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