Oncology/Hematology

Latest AI and machine learning research in oncology/hematology for healthcare professionals.

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Showing 13421-13440 of 19,032 articles

Training Beyond Convergence: Grokking nnU-Net for Glioma Segmentation in Sub-Saharan MRI

Gliomas are placing an increasingly clinical burden on Sub-Saharan Africa (SSA). In the region, the median survival for patients remains under two years, and access to diagnostic imaging is extremely limited. These constraints highlight an urgent need for automated tools that can extract the maximum possible information from each available scan, tools that are specifically trained on local data, r...

Jan 30 2026 2601.22637v1

HistoPrism: Unlocking Functional Pathway Analysis from Pan-Cancer Histology via Gene Expression Prediction

Predicting spatial gene expression from H&E histology offers a scalable and clinically accessible alternative to sequencing, but realizing clinical impact requires models that generalize across cancer types and capture biologically coherent signals. Prior work is often limited to per-cancer settings and variance-based evaluation, leaving functional relevance underexplored. We introduce HistoPrism,...

Jan 29 2026 2601.21560v2
Breast cancer radiogenomics analysis via computational perturbation on AI-driven multi-omics guided image synthesis

Radiogenomics offers a promising non-invasive approach for characterizing breast cancer (BC), yet its progress is often limited by the scarcity of coh...

A neural network model delivers a highly prognostic protein signature in cancer stem cells that identifies relapse in stage III colorectal cancer patients.

Background Stage III colorectal cancer poses a significant threat of metastasis development, as tumour resection and adjuvant chemotherapy do not guar...

HistoPrism: Unlocking Functional Pathway Analysis from Pan-Cancer Histology via Gene Expression Prediction

Predicting spatial gene expression from H&E histology offers a scalable and clinically accessible alternative to sequencing, but realizing clinical im...

Jan 29 2026 2601.21560v1
Early and Prediagnostic Detection of Pancreatic Cancer from Computed Tomography

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid malignancies, is often detected at a late and inoperable stage. Retrospective revi...

Jan 29 2026 2601.22134v1
Global mRNA 3'UTR lengthening in small-cell neuroendocrine carcinoma

Small-cell neuroendocrine carcinoma (SCNC) is a rare but highly malignant tumor subtype that primarily arises in the lung, also rarely in other organs...

SegRap2025: A Benchmark of Gross Tumor Volume and Lymph Node Clinical Target Volume Segmentation for Radiotherapy Planning of Nasopharyngeal Carcinoma

Accurate delineation of Gross Tumor Volume (GTV), Lymph Node Clinical Target Volume (LN CTV), and Organ-at-Risk (OAR) from Computed Tomography (CT) sc...

Jan 28 2026 2601.20575v1
BULLKpy: An AnnData-Inspired Unified Framework for Comprehensive Bulk OMICs Analysis

Bulk OMICs data, such as RNA-seq and proteomics, remain foundational in biomedical and cancer research. While single-cell transcriptomics has revoluti...

Why Large Language Models' Clinical Reasoning Fails: Insights from Explainable Deep Learning

BACKGROUND Medical large language models (LLMs) achieving high benchmark accuracy exhibit unexplained variability in clinical tasks, producing errors ...

Prioritizing DNA methylation biomarkers using graph neural networks and explainable AI

DNA methylation is a significant epigenetic modification involving the addition of a methyl group to the position 5' of the cytosine residues. The mod...

Glance and Focus Reinforcement for Pan-cancer Screening

Pan-cancer screening in large-scale CT scans remains challenging for existing AI methods, primarily due to the difficulty of localizing diverse types ...

Jan 27 2026 2601.19103v1
Pareto-Guided Optimization for Uncertainty-Aware Medical Image Segmentation

Uncertainty in medical image segmentation is inherently non-uniform, with boundary regions exhibiting substantially higher ambiguity than interior are...

Jan 27 2026 2601.19365v1
FusionPath: Gene fusion pathogenicity prediction using protein structural data and contextual protein embeddings

Accurate prediction of gene fusion pathogenicity is critical for understanding oncogenic mechanisms and advancing precision oncology. While existing c...

End-to-end deep learning versus machine learning for biomarker discovery in cancer genomes

Background: Accurate determination of genomic biomarkers from tumor sequencing is fundamental to precision oncology, informing disease classification ...

LungCRCT: Causal Representation based Lung CT Processing for Lung Cancer Treatment

Due to silence in early stages, lung cancer has been one of the most leading causes of mortality in cancer patients world-wide. Moreover, major sympto...

Jan 26 2026 2601.18118v1
A Tumor Aware DenseNet Swin Hybrid Learning with Boosted and Hierarchical Feature Spaces for Large-Scale Brain MRI Classification

This study proposes an efficient Densely Swin Hybrid (EDSH) framework for brain tumor MRI analysis, designed to jointly capture fine grained texture p...

Jan 26 2026 2601.18330v1
TwinPurify: Purifying gene expression data to reveal tumor-intrinsic transcriptional programs via self-supervised learning

Advances in single-cell and spatial transcriptomic technologies have transformed tumor ecosystem profiling at cellular resolution. However, large scal...

Jan 26 2026 2601.18640v1
Analyzing Images of Blood Cells with Quantum Machine Learning Methods: Equilibrium Propagation and Variational Quantum Circuits to Detect Acute Myeloid Leukemia

This paper presents a feasibility study demonstrating that quantum machine learning (QML) algorithms achieve competitive performance on real-world med...

Jan 26 2026 2601.18710v1
Robust Computational Extraction of Non-Enhancing Hypercellular Tumor Regions from Clinical Imaging Data

Accurate identification of non-enhancing hypercellular (NEH) tumor regions is an unmet need in neuro-oncological imaging, with significant implication...

Jan 25 2026 2601.17802v1
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