Latest AI and machine learning research in oncology/hematology for healthcare professionals.
Cell-free DNA (cfDNA) methylation is a valuable biomarker in various cancers including colorectal cancer (CRC), but marker for both early diagnosis and prognostic prediction remain a critical unmet need. Here, we report the development of a 27-DMR (differentially methylated regions) plasma panel with dual diagnostic and prognostic functions. We first identified CRC-specific methylation features fr...
Conventional assessment of Focal Segmental Glomerulosclerosis and Minimal Change Disease focuses on the presence/extent of segmental (SS) and global (GS) glomerulosclerosis. While SS and GS represent ongoing and terminal process, encoded in non-SS/GS glomeruli is prognostic information that can be extracted before structural changes are visually discernable. This study applies computational image ...
Medical imaging is crucial for glioma management. Combined with MRI, amino acid PET may improve glioma diagnosis, biopsy targeting, and tumor delineat...
To determine if combining PET-derived beta-cell mass (BCM) estimates with MRI- based morphology metrics improves the prediction of beta-cell functiona...
Survival analysis is essential in oncology for modeling time-to-event outcomes such as overall survival and disease recurrence. Traditional approaches...
Neoadjuvant therapy, involving treatment administered before surgery to shrink tumors, significantly impacts breast cancer management. However, curren...
To evaluate whether open-source histopathology foundation model pipelines, paired with attention-based multiple instance learning (MIL), can accuratel...
Thymic involution, characterized by adipose replacement of functional thymic tissue, is a broadly recognized feature of age-related immunosenescence. ...
Early detection and treatment of head and neck squamous cell carcinoma (HNSC) and oral squamous cell carcinoma (OSCC) could decrease the existing high...
Background: Continuous Positive Airway Pressure (CPAP) therapy is the standard treatment for obstructive sleep apnea-hypopnea syndrome, yet its use as...
Overall survival (OS) remains the gold standard for oncology drug approval, but measuring it requires long follow-up and is impractical in certain onc...
To evaluate the translational capabilities of foundation models, we develop a pathological concept learning approach focused on kidney cancer. By leve...
Buparlisib, a pan-class I PI3K inhibitor, combined with paclitaxel, demonstrated improved survival in the BERIL-1 trial for patients with recurrent/me...
Head and neck squamous cell carcinoma (HNSCC) is ranked sixth among all the common cancers worldwide and is a major cause of death. A molecular unders...
Radiotherapy treatment planning is a resource-intensive process characterized by multiple manual steps and clinical hand-offs that contribute to treat...
Immunotherapy has improved outcomes for advanced-stage melanoma, however, predictive biomarkers remain limited. We evaluated whether computed tomograp...
Clinicopathologic calculators for bladder cancer moderately predict survival and fail to depict the underlying molecular phenotype. We applied urinary...
Leiomyosarcoma (LMS) is a rare and aggressive soft tissue sarcoma with limited treatment options and poor prognosis. Standard therapies, including dox...
Progress in artificial intelligence-based analysis of surgical videos has been constrained by reliance on manual frame-level annotations rather than p...
The incidence of early-onset colorectal cancer (EOCRC; <50 years) continues to rise, with the most rapid increases observed among Hispanic/Latino (H/L...