Ophthalmology

Latest AI and machine learning research in ophthalmology for healthcare professionals.

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Deep learning-driven characterization of single cell tuning in primate visual area V4 supports topological organization

Deciphering the brain’s structure-function relationship is key to understanding the neuronal mechanisms underlying perception and cognition. The cortical column, a vertical organization of neurons with similar functions, is a classic example of primate neocortex structure-function organization. While columns have been identified in primary sensory areas using parametric stimuli, their prevalence a...

A unifying account of replay as context-driven memory reactivation

During rest and sleep, sequential neural activation patterns corresponding to awake experience re-emerge, and this replay has been shown to benefit subsequent behavior and memory. Whereas some studies show that replay directly recapitulates recent experience, others demonstrate that replay systematically deviates from the temporal structure, the statistics, and even the content of recent experienc...

SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies

Spiking neural networks (SNNs) have attracted growing interest for their ability to operate efficiently on low-power neuromorphic hardware, offering a...

Gaze reinstatement during working memory for natural scenes

The information we hold in mind with working memory (WM) may propagate beyond the cortex and out to the peripheral motor system. For instance, directi...

Hierarchical Community Structure of the Adult Drosophila Connectome Reveals Conserved Circuit Archetypes

Biological neural networks can be meaningfully partitioned into sub-networks referred to as communities. Community structure is thought to support fun...

Connectome of a human foveal retina

The foveal retina is a primate specialization which presents a feasible site for obtaining a complete connectome of a human CNS structure. In the fove...

Alignment of Artificial Neural Networks with Human Eye Movement Patterns in Facial Expression Recognition

Artificial neural networks (ANNs) have become powerful tools for modeling human perception and hehavior, yet it remains unclear if they resemble the s...

A large-scale dataset of functional mouse ganglion cell layer responses

We present the All-GCL dataset, a large-scale resource of functional two-photon Ca2+-imaging recordings with rich meta-data information from more than...

Trial-by-trial inter-areal interactions in visual cortex in the presence or absence of visual stimulation

State-of-the-art computational models of vision largely focus on fitting trial-averaged spike counts to visual stimuli using overparameterized neural ...

A Structure-Aware Generative AI Framework for Revealing Functional Relationships in Proteins Families

The rapid expansion of protein sequence databases has far outpaced experimental structure determination, leaving many unannotated sequences, particula...

GENET: AI-Powered Interactive Visualization Workflows to Explore Biomedical Entity Networks

Formulating hypotheses about gene-disease associations requires logical inference from prior data, followed by a laborious literature review. AI model...

MAYOCTransformer: Masked-Attention for Yielding Comprehensive Semantic Segmentation of Retinal Optical Coherence Tomography Images using Transformer-based Neural Networks

Optical coherence tomography (OCT) is a widely used imaging modality in ophthalmology. Accurate semantic segmentation of these images is critical for ...

Can We Extract Physics-like Energies from Generative Protein Diffusion Models?

Diffusion models have emerged as the state-of-the-art method in generative artificial intelligence (AI) and have shown great success in image synthesi...

Modeling and Design of Multi-layered Cylindrical Microcapsules for Intravitreal Controlled Release

Chronic diseases often require repeated oral or local administration, which can compromise patient compliance. In wet age-related macular degeneration...

Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic Regression

To characterize cell type specific transcriptional changes during human retinal aging and develop machine learning model for cellular age discriminati...

Equity-Enhanced Glaucoma Progression Prediction from OCT with Knowledge Distillation

To develop an equitable deep learning model with knowledge distillation to enhance the demographic equity in glaucoma progression prediction. We devel...

Retinal vascularization rate predicts retinopathy of prematurity and remains unaffected by low-dose bevacizumab treatment

To assess the rate of retinal vascularisation derived from ultra-widefield (UWF) imaging-based retinopathy of prematurity (ROP) screening as predictor...

Machine learning methods to track dynamic facial function in facial palsy

For patients with facial paralysis, the wait for return of facial function and resulting vision risk from poor eye closure, difficulty speaking and ea...

Performance of DeepSeek-R1 in Ophthalmology: An Evaluation of Clinical Decision-Making and Cost-Effectiveness

To compare the performance and cost-effectiveness of DeepSeek-R1 with OpenAI o1 in diagnosing and managing ophthalmology clinical cases. Cross-section...

An Efficient and Interpretable Foundation Model for Retinal Image Analysis in Disease Diagnosis

Artificial intelligence (AI) foundation models for colour fundus photography (CFP) have been extensively studied and demonstrated great potential for ...

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