Ophthalmology

Latest AI and machine learning research in ophthalmology for healthcare professionals.

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Detecting neurodegenerative changes in glaucoma using deep mean kurtosis-curve–corrected tractometry

Glaucoma is increasingly recognized as a neurodegenerative condition involving both retinal and central nervous system structures. Here, we present an integrated framework that combines MK-Curve-corrected diffusion kurtosis imaging (DKI), tractometry, and deep autoencoder-based normative modeling to detect localized white matter abnormalities associated with glaucoma. Using UK Biobank diffusion MR...

Assessing the Potential of AI-Driven Drug Repurposing in Ophthalmology: An Analysis of ChatGPT’s Therapeutic Recommendations

This study aimed to evaluate the novelty and potential value of therapeutic suggestions made by an artificial intelligence large language model for treating various ophthalmic diseases. ChatGPT-3.5 was used to suggest novel ophthalmic indications for available medications. The generation of therapeutic suggestions was performed by inputting standardized queries about treatments for common ophthalm...

Assessing Large Language Model Utility and Limitations in Diabetes Education: A Cross-Sectional Study of Patient Interactions and Specialist Evaluations

To assess the value of an AI-powered conversational agent in supporting diabetes self-management among adults with diabetic retinopathy and limited ed...

Clinically Interpretable Deep Learning via Sparse BagNets for Epiretinal Membrane and Related Pathology Detection

Epiretinal membrane (ERM) is a vitreoretinal interface disease that, if not properly addressed, can lead to vision impairment and negatively affect qu...

Artificial Intelligence for Early Detection and Prognosis Prediction of Diabetic Retinopathy

This review explores the transformative role of artificial intelligence (AI) in the early detection and prognosis prediction of diabetic retinopathy (...

An Open-Source Generalizable Deep Learning Framework for Automated Corneal Segmentation in Anterior Segment Optical Coherence Tomography Imaging

To develop a deep learning model – Cornea nnU-Net Extractor (CUNEX) – for full-thickness corneal segmentation of anterior segment optical coherence to...

Prompt injection attacks on vision-language models for surgical decision support

Artificial Intelligence-driven analysis of laparoscopic video holds potential to increase the safety and precision of minimally invasive surgery. Visi...

Automated Deep Learning-Based 3D-to-2D Segmentation of Geographic Atrophy in Optical Coherence Tomography Data

We report on a deep learning-based approach to the segmentation of geographic atrophy (GA) in patients with advanced age-related macular degeneration ...

The Golgi Apparatus as an Arbiter of Oncofetal Reprogramming: A Systematic Review and Meta-Analysis Linking Embryonic Germ Layer Origin to the Post-Translational Modification Landscape of Cancer

Post-translational modifications (PTMs) represent a fourth dimension of the genetic code, orchestrated by the Golgi apparatus and central to the biolo...

GlaucoRAG: A Retrieval-Augmented Large Language Model for Expert-Level Glaucoma Assessment

Purpose: Accurate glaucoma assessment is challenging because of the complexity and chronic nature of the disease; therefore, there is a critical need ...

Advances and limitations of artificial intelligence-assisted identification of pathogenic fungi

We developed and tested multiple computer-vision image classifiers, for their ability to identify a large set of common and rare pathogenic molds. Aim...

Assessing ChatGPT’s Performance in Delineating Uveitis: An analysis of responses to real-world case presentations

In the world of Artificial Intelligence (AI), Generative Pretrained Transformer-3 (GPT-3), has gained significant popularity for its demonstrated pote...

Detecting Fifth Metatarsal Fractures on Radiographs through the Lens of Smartphones: A FIXUS AI Algorithm

Fifth metatarsal (5MT) fractures are common but challenging to diagnose, particularly with limited expertise or subtle fractures. Deep learning shows ...

SLOTMFound: Foundation-Based Diagnosis of Multiple Sclerosis Using Retinal SLO Imaging and OCT Thickness-maps

Multiple Sclerosis (MS) is a chronic autoimmune disorder of the central nervous system that can lead to significant neurological disability. Retinal i...

Quantification of Optical Coherence Tomography Features in >3500 Patients with Inherited Retinal Disease Reveals Novel Genotype-Phenotype Associations

To quantify spectral-domain optical coherence tomography (SD-OCT) images cross-sectionally and longitudinally in a large cohort of molecularly charact...

A conversational artificial intelligence based web application for medical conversations: a prototype for a chatbot

Artificial Intelligence (AI) has evolved through various trends, with different subfields gaining prominence over time. Currently, Conversational Arti...

Explainable machine learning for post PKR surgery follow-up

Photorefractive Keratectomy (PRK) is a widely used laser-assisted refractive surgical technique. In some cases, it leads to temporary subepithelial in...

Benchmarking Multimodal Large Language Models for Forensic Science and Medicine: A Comprehensive Dataset and Evaluation Framework

Multimodal large language models (MLLMs) have demonstrated substantial progress in medical and legal domains in recent years; however, their capabilit...

Personalized, closed-loop deep brain stimulation for chronic pain

Chronic pain is a major healthcare problem associated with maladaptive brain circuit changes - many patients are unresponsive to all available therapi...

AI-GUIDED ENDPOINT SELECTION FOR NEUROPROTECTION TRIALS IN GLAUCOMA

Standard Automated Perimetry (SAP) is the mainstay for monitoring glaucoma progression and has been accepted by the U.S. Food and Drug Administration ...

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