Ophthalmology

Latest AI and machine learning research in ophthalmology for healthcare professionals.

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Big data in ophthalmology: comparative databases and research applications.

PURPOSE OF REVIEW: This review aims to highlight the expanding role of big data in ophthalmology, provide a comparison of the most prominent databases, and their use in glaucoma-specific research. Understanding the strengths and limitations of each database allows researchers to tailor their research questions appropriately. RECENT FINDINGS: Several large-scale databases have emerged in ophthalmol...

Nov 27 2025 41329931

Anterior segment optical coherence tomography imaging in angle closure: advances in diagnosis and care.

PURPOSE OF REVIEW: To highlight emerging applications of anterior segment optical coherence tomography (AS-OCT) in the diagnosis, risk stratification, and management of angle closure glaucoma, with particular emphasis on the integration of artificial intelligence. RECENT FINDINGS: AS-OCT enables objective and reproducible quantification of anterior chamber angle parameters, overcoming the subjecti...

Nov 27 2025 41431253
Perspectives on screening in retinopathy of prematurity: new algorithms and AI tools.

Retinopathy of prematurity (ROP) is a vasoproliferative blinding disorder of the retina, unique to premature infants and a leading cause of preventabl...

Nov 26 2025 41298074
Revisiting KANET in the context of fetal connectomics: defining optimal gestational windows for neurodevelopmental screening.

OBJECTIVES: To introduce the KANET-connectome matrix (KANET-Con) as a conceptual framework linking fetal behaviors observed on four-dimensional (4D) u...

Nov 26 2025 41285677
Quantitative Analysis of Instrument Motion Paths in Cataract Surgery across a Resident's Training.

PURPOSE: To objectively quantify the motion paths of surgical instruments during cataract surgery across a resident's training, identifying patterns o...

Nov 26 2025 41552663
Social Integration Among Rural-to-Urban Migrants: A Dynamic Analysis Using a Hybrid Approach Integrating Structural Equation Modeling and Machine Learning.

Against the backdrop of China's new urbanization and regional coordination strategies, the social integration of rural-to-urban migrants has become an...

Nov 25 2025 41287562
Interpretable machine learning model based on blood parameters for screening high myopia.

OBJECTIVE: To develop an interpretable machine learning (ML) model using routine blood parameters for high myopia (HM) screening as a convenient and c...

Nov 25 2025 41291243
Visual input statistics and behavioral relevance jointly constrain higher visual cortex organization.

Ritchie and colleagues propose that the functional organization of higher visual cortex is best understood through the lens of behavioral relevance, a...

Nov 23 2025 41276824
Reveal a risk and potential mechanism for keratoconus progression with isotretinoin: Toxicogenomic, transcriptomics and real-world evidence insights.

PURPOSE: Limited clinical data and unstable animal models hinder understanding isotretinoin-induced keratoconus. We addressed this by integrating phar...

Nov 22 2025 41285218
Choroidal volume decrease associated with stromal regression in adult myopia: A high-resolution optical coherence tomography angiography study.

PURPOSE: Observing choroidal volume changes in myopia with various degrees via spectral-domain optical coherence tomography (SD-OCT) images. METHODS: ...

Nov 20 2025 41274326
OCT-PRO: A Multimodal Model Integrating OCT and Clinical Traits to Predict Postoperative Outcomes in Cataract Patients.

PURPOSE: To develop and validate OCT-PRO, a multimodal machine learning model integrating OCT images and clinical traits to predict postoperative visu...

Nov 17 2025 41532137
Artificial intelligence-driven CT radiomics model predicts prognosis in TACE-refractory hepatocellular carcinoma.

PURPOSE: To develop an integrated predictive model combining radiomics, clinical risk factors, and machine learning for prognostic assessment in hepat...

Nov 14 2025 41236585
Retinal Age Gap as a Biomarker for Patient Satisfaction and Visual Quality After Cataract Surgery.

PURPOSE: To evaluate whether the difference between artificial intelligence (AI)-estimated retinal biological age and chronological age-the retinal ag...

Nov 13 2025 41241358
Scaling up self-supervised learning for improved surgical foundation models.

Foundation models have revolutionized computer vision by achieving vastly superior performance across diverse tasks through large-scale pretraining on...

Nov 13 2025 41297512
Comparison of RETFound and a Supervised Convolutional Neural Network for Detection of Referable Glaucoma from Fundus Photographs.

PURPOSE: To compare the performance of a vision transformer-based foundation model (RETFound) and a supervised convolutional neural network (VGG-19) f...

Nov 12 2025 41552656
Special AAO Report: Recommendations on Screening for Hydroxychloroquine Retinopathy (2025 Revision).

BACKGROUND: The American Academy of Ophthalmology recommendations on screening for hydroxychloroquine (HCQ) retinopathy are now a decade old. This rev...

Nov 11 2025 41232611
Accuracy and Readability of Chat Generative Pre-Trained Transformer-4 Omni in Answering Ophthalmology Patient Questions.

PURPOSE: To assess the quality of Chat Generative Pre-Trained Transformer-4 Omni (ChatGPT-4o) responses to questions submitted by patients through Epi...

Nov 11 2025 41488567
Data-Driven Detection of Subclinical Keratoconus via Semi-Supervised Clustering of Multidimensional Corneal Biomarkers.

PURPOSE: To objectively identify subclinical keratoconus (SKC) from a large sample of healthy and keratoconus (KC) patients via a data-driven framewor...

Nov 11 2025 41488568
Benchmarking AlphaMissense against ClinVar for Diagnostic Interpretation of Missense Variants in Inherited Retinal Diseases.

PURPOSE: AlphaMissense is a newer deep learning-based variant predictor that evaluates the structural consequences of missense variants, the most comm...

Nov 10 2025 41492285
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