Ophthalmology

Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina.

Most genetic risk variants linked to ocular diseases are nonprotein coding and presumably contribute to disease through dysregulation of gene expression; however, understanding their mechanisms has been impeded by incomplete annotation of transcriptional regulatory elements across retinal cell types. To address this, we carried out single-cell multiomics assays to investigate gene expression, chro...

Using Large Language Models to Generate Retina Patient Education Material: A Comparative Analysis With American Society of Retina Specialists Patient Brochures.

PURPOSE: To evaluate the readability, quality, and misinformation of patient education materials generated by large language models, including ChatGPT-4o (OpenAI), Gemini 1.5 Pro (Google), and Copilot Pro (Microsoft), compared with American Society of Retina Specialists (ASRS) brochures for retinal diseases. METHODS: A cross-sectional comparative analysis was performed by generating patient educat...

Reconfigurable Nonvolatile Photodetectors for Brain-Inspired Vision.

Machine vision serves as the essential sensorial interface for intelligent systems, yet conventional vision systems based on the von Neumann architect...

Assessment and prediction of driving risk at tunnel entrance and exit sections on mountainous roads.

OBJECTIVES: To investigate the spatial evolution of driving visual load under different road alignment conditions and its relationship with driving ri...

Multimodal foundation model assistance for differentiating primary open-angle glaucoma in highly myopic eyes.

PURPOSE: To develop and evaluate a multimodal foundation-model-assisted system for differentiating primary open-angle glaucoma (POAG) from non-glaucom...

Clinically aligned artificial intelligence for glaucoma diagnosis: enhancing retinal nerve fibre layer interpretation from fundus images.

BACKGROUND/OBJECTIVES: This study aimed to develop an interpretable artificial intelligence (AI) screening system that replicates a specialist's evalu...

Autonomous robotic alignment and dynamic illumination control of an ophthalmic slit lamp for in vivo anterior segment imaging.

SIGNIFICANCE: The slit lamp is the gold standard ophthalmic instrument for examining the anterior segment of the eye. Slit lamps require the mechanica...

Multilingual Voice AI for Postoperative Cataract Follow-Up in Turkish Speaking Patients in the United Kingdom: Patient and Public Involvement Focus Group Study.

BACKGROUND: Conversational voice AI assistants can automate postoperative follow-up calls in high-volume, low-complexity pathways such as cataract sur...

Advanced analysis of leading large language models for diagnostic accuracy in retinal imaging.

BACKGROUND/AIMS: To evaluate and compare the diagnostic capabilities of advanced large language models (LLMs) in interpreting ophthalmological fundus ...

Effect of cataracts on systemic factor prediction from fundus images.

OBJECTIVE: To evaluate the effect of cataracts on systemic factor predictions from fundus images by comparing predictive values before and after catar...

Teleophthalmology for Retinal Disease Screening and Referral in Low- and Middle-Income Countries: A Case Overview of India.

Innovations like teleophthalmology have made great strides in improving access to care for patients with retinal disease by enabling prompt screening ...

[Telemetric self-monitoring of intraocular pressure: from vision to reality? : Insights from the EyeMate-SC sensor].

BACKGROUND: The EyeMate-SC (G-Metrics GmbH, Hanover, Germany) is a permanently implantable microsensor positioned in the suprachoroidal space for tele...

Comprehensive Characterization of Clinical Phenotypes and CTG Repeat-Associated Manifestations in Spinocerebellar Ataxia Type 8.

Spinocerebellar ataxia type 8 (SCA8) is traditionally characterized as a cerebellar syndrome, yet emerging evidence suggests significant phenotypic he...

Automated acute pain assessment in brachycephalic cats with ocular pain using the Feline Grimace Scale.

OBJECTIVES: This study aimed to evaluate the feasibility and limitations of an AI-powered Feline Grimace Scale (FGS) pipeline for acute pain assessmen...

[Sarcoidosis-associated uveitis: Current status and future prospects].

Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at any age but preferentially affects adults aged 30 ...

Unraveling the phenomenon of losing humanness at workplace: A review and synthesis of dehumanization research in work context.

Dehumanization in workplace contexts has recently gained attention due to contemporary factors such as the rapid increase in information, communicatio...

Quantitative reference map of retinopathy of prematurity improves diagnostic reliability and treatment decisions.

BACKGROUND/AIMS: Retinopathy of prematurity (ROP) zone classification guides disease severity assessment and Early Treatment for Retinopathy of Premat...

A smart vision assistance system designed for the cybathlon 2024 vision assistance race to support individuals with visual impairments.

Individuals with visual impairments continue to face challenges in performing everyday tasks, despite ongoing advances in assistive technologies. In t...

Artificial Intelligence in Inherited Retinal Diseases: Imaging-Based Applications and Emerging Trends.

INTRODUCTION: Inherited retinal diseases (IRDs) represent a heterogeneous group of progressive disorders that lead to visual impairment and blindness ...

Innovative AI-based system for precision diagnosis of childhood strabismus incorporating gaze tracking and real-time correction feedback.

PurposeStrabismus is a common pediatric eye disorder that can lead to developmental and psychosocial consequences if not treated promptly. Traditional...