Latest AI and machine learning research in orthopedics for healthcare professionals.
Invertebrate and larval model organisms such as Drosophila melanogaster, Caenorhabditis elegans, Danio rerio larvae, and Galleria mellonella are increasingly employed in biomedical, toxicological, and ecological research. Their behavioral responses serve as sensitive indicators of functional changes, yet traditional methods of observation remain low-throughput, subjective, and poorly scalable. Art...
A key problem in learning is credit assignment. Biological systems lack a plausible mechanism to implement the backpropagation approach, a method that underlies much of the dramatic progress in artificial intelligence. Here, we use automated connectomic analysis to show that the synaptic architecture of songbird basal ganglia (Area X) supports local credit assignment using a variant of a node pert...
Joint pain is an increasing concern for our aging population, as current therapies to slow joint disease progression or reduce pain are largely ineffe...
As spatially resolved transcriptomics (SRT) datasets increasingly span multiple adjacent or replicated slices, effective joint analysis across slices ...
Gene expression changes across embryonic development reflect both differentiation and genes whose expression varies strictly with developmental time, ...
Tracking prey or recognizing a lurking predator is as crucial for survival as anticipating their actions. To guide behavior, the brain must extract in...
Objective radiographic measures of heart size including vertebral heart size (VHS) and vertebral left atrial size (VLAS) are associated with inter and...
Over the past sixty years, evidence accumulation models have emerged as a dominant framework for explaining the neural and behavioral aspects of the p...
The intricate architecture of skeletal muscle is essential for its contractile function, with the spatial organization of organelles such as T-tubules...
Musculoskeletal dynamics influence the progression and rehabilitation of many movement-related conditions. However, accurately estimating whole-body d...
Recent advances in connectomics have been led by high-resolution reconstruction of large volumes of neural tissues using electron microscopy (EM), pro...
Motile cilia coordinate fluid flows that are essential for normal tissue physiology and function. Cilia display diverse beating waveforms, and while p...
Biomechanical biofeedback has the potential to enhance rehabilitation by providing clinicians with objective evaluation of patient performances. As fe...
The zebrafish (Danio rerio) is a critical vertebrate model organism in biomedical research. Accurate identification and longitudinal tracking of indiv...
The bone marrow (BM) is the main site of haematopoiesis in adult life. Our understanding of the pathogenesis of BM-derived blood cancers is limited by...
Vertebral heart size (VHS) and vertebral left atrial size (VLAS) are objective radiographic measurements of heart and left atrial size respectively an...
Acute myeloid leukemia (AML) often enters remission after chemotherapy but frequently relapses due to chemotherapy-resistant leukemic stem cells (LSCs...
Genomic prediction and design require models that integrate local sequence features with long-range regulatory dependencies spanning hundreds of kilob...
Malaria in sub-Saharan Africa is transmitted by mosquitoes, in particular the Anopheles gambiae complex. Efforts to control the spread of malaria have...
Behavioral datasets for invertebrate model organisms are rapidly expanding alongside automated imaging, tracking, and artificial intelligence (AI) bas...